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- W4303946492 endingPage "3163" @default.
- W4303946492 startingPage "3163" @default.
- W4303946492 abstract "Environmental toxicants (ETs) are an exogenous chemical group diffused in the environment that contaminate food, water, air and soil, and through the food chain, they bioaccumulate into the organisms. In mammals, the exposure to ETs can affect both male and female fertility and their reproductive health through complex alterations that impact both gametogeneses, among other processes. In humans, direct exposure to ETs concurs to the declining of fertility, and its transmission across generations has been recently proposed. However, multi- and transgenerational inheritances of ET reprotoxicity have only been demonstrated in animals. Here, we review recent studies performed on laboratory model animals investigating the effects of ETs, such as BPA, phthalates, pesticides and persistent contaminants, on the reproductive system transmitted through generations. This includes multigenerational effects, where exposure to the compounds cannot be excluded, and transgenerational effects in unexposed animals. Additionally, we report on epigenetic mechanisms, such as DNA methylation, histone tails and noncoding RNAs, which may play a mechanistic role in a nongenetic transmission of environmental information exposure through the germline across generations." @default.
- W4303946492 created "2022-10-10" @default.
- W4303946492 creator A5024456899 @default.
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- W4303946492 creator A5071249465 @default.
- W4303946492 date "2022-10-09" @default.
- W4303946492 modified "2023-10-04" @default.
- W4303946492 title "Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction" @default.
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