Matches in SemOpenAlex for { <https://semopenalex.org/work/W4303946575> ?p ?o ?g. }
- W4303946575 endingPage "4942" @default.
- W4303946575 startingPage "4942" @default.
- W4303946575 abstract "Cancer stem cells (CSCs) represent a therapy-resistant reservoir in glioblastoma (GBM). It is now becoming clear that epigenetic and chromatin remodelling programs link the stemlike behaviour of CSCs to their treatment resistance. New evidence indicates that the epigenome of GBM cells is shaped by intrinsic and extrinsic factors, including their genetic makeup, their interactions and communication with other neoplastic and non-neoplastic cells, including immune cells, and their metabolic niche. In this review, we explore how all these factors contribute to epigenomic heterogeneity in a tumour and the selection of therapy-resistant cells. Lastly, we discuss current and emerging experimental platforms aimed at precisely understanding the epigenetic mechanisms of therapy resistance that ultimately lead to tumour relapse. Given the growing arsenal of drugs that target epigenetic enzymes, our review addresses promising preclinical and clinical applications of epidrugs to treat GBM, and possible mechanisms of resistance that need to be overcome." @default.
- W4303946575 created "2022-10-10" @default.
- W4303946575 creator A5006060509 @default.
- W4303946575 creator A5051814944 @default.
- W4303946575 creator A5078257061 @default.
- W4303946575 creator A5091036806 @default.
- W4303946575 date "2022-10-09" @default.
- W4303946575 modified "2023-10-14" @default.
- W4303946575 title "Roles of Chromatin Remodelling and Molecular Heterogeneity in Therapy Resistance in Glioblastoma" @default.
- W4303946575 cites W1500090790 @default.
- W4303946575 cites W1583659949 @default.
- W4303946575 cites W1666901150 @default.
- W4303946575 cites W1878244711 @default.
- W4303946575 cites W1903281529 @default.
- W4303946575 cites W1905278501 @default.
- W4303946575 cites W1953890763 @default.
- W4303946575 cites W1964150693 @default.
- W4303946575 cites W1965306647 @default.
- W4303946575 cites W1968931043 @default.
- W4303946575 cites W1975282459 @default.
- W4303946575 cites W1977943782 @default.
- W4303946575 cites W1988756388 @default.
- W4303946575 cites W1989891384 @default.
- W4303946575 cites W1990739246 @default.
- W4303946575 cites W1997099893 @default.
- W4303946575 cites W2001544973 @default.
- W4303946575 cites W2006618903 @default.
- W4303946575 cites W2007916651 @default.
- W4303946575 cites W2011983814 @default.
- W4303946575 cites W2015755329 @default.
- W4303946575 cites W2017840637 @default.
- W4303946575 cites W2023560061 @default.
- W4303946575 cites W2030017878 @default.
- W4303946575 cites W2033364737 @default.
- W4303946575 cites W2038570555 @default.
- W4303946575 cites W2039075677 @default.
- W4303946575 cites W2039872271 @default.
- W4303946575 cites W2040458067 @default.
- W4303946575 cites W2051588629 @default.
- W4303946575 cites W2052630543 @default.
- W4303946575 cites W2054643318 @default.
- W4303946575 cites W2060551076 @default.
- W4303946575 cites W2061760261 @default.
- W4303946575 cites W2062062519 @default.
- W4303946575 cites W2065970275 @default.
- W4303946575 cites W2069591815 @default.
- W4303946575 cites W2073586533 @default.
- W4303946575 cites W2076333986 @default.
- W4303946575 cites W2078510083 @default.
- W4303946575 cites W2080452140 @default.
- W4303946575 cites W2081038378 @default.
- W4303946575 cites W2087814592 @default.
- W4303946575 cites W2092015664 @default.
- W4303946575 cites W2094089029 @default.
- W4303946575 cites W2096287682 @default.
- W4303946575 cites W2106391833 @default.
- W4303946575 cites W2108076325 @default.
- W4303946575 cites W2108664872 @default.
- W4303946575 cites W2109816625 @default.
- W4303946575 cites W2110265246 @default.
- W4303946575 cites W2111940175 @default.
- W4303946575 cites W2115276344 @default.
- W4303946575 cites W2116236561 @default.
- W4303946575 cites W2119793842 @default.
- W4303946575 cites W2122674384 @default.
- W4303946575 cites W2123349002 @default.
- W4303946575 cites W2126817554 @default.
- W4303946575 cites W2133437282 @default.
- W4303946575 cites W2136120736 @default.
- W4303946575 cites W2139381148 @default.
- W4303946575 cites W2143995836 @default.
- W4303946575 cites W2144137532 @default.
- W4303946575 cites W2147524392 @default.
- W4303946575 cites W2151718828 @default.
- W4303946575 cites W2152656267 @default.
- W4303946575 cites W2154313451 @default.
- W4303946575 cites W2158233796 @default.
- W4303946575 cites W2158681922 @default.
- W4303946575 cites W2160689782 @default.
- W4303946575 cites W2161289668 @default.
- W4303946575 cites W2162012621 @default.
- W4303946575 cites W2165871546 @default.
- W4303946575 cites W2167650288 @default.
- W4303946575 cites W2179638825 @default.
- W4303946575 cites W2181468201 @default.
- W4303946575 cites W2320983896 @default.
- W4303946575 cites W2432608352 @default.
- W4303946575 cites W2504379340 @default.
- W4303946575 cites W2511206720 @default.
- W4303946575 cites W2561012755 @default.
- W4303946575 cites W2610673469 @default.
- W4303946575 cites W2727119164 @default.
- W4303946575 cites W2752214746 @default.
- W4303946575 cites W2756777461 @default.
- W4303946575 cites W2758553652 @default.
- W4303946575 cites W2761941966 @default.
- W4303946575 cites W2769376917 @default.
- W4303946575 cites W2770894379 @default.