FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4303946586> ?p ?o ?g. }

• W4303946586 endingPage "4943" @default.
• W4303946586 startingPage "4943" @default.
• W4303946586 abstract "This study aims to explore the role of abnormal fatty acid metabolism (FAM) in ccRCC and construct a novel fatty acid metabolism-related gene signature (FAMGS) for prognosis. Three independent ccRCC cohorts, including The Cancer Genome Atlas, E-MTAB-1980 and our clinical cohort (including RNA-seq, microarray and RT-qPCR data), were applied as training and two independent validation cohorts. Firstly, FAM levels were found to be significantly decreased in ccRCC and correlated with degrees of malignancy, confirming the pivotal role of FAM in ccRCC. Applying the least absolute shrinkage and selection operator cox regression, we established a novel FAMGS for overall survival (OS). The FAMGS divided patients into low or high-risk groups in the training cohort and were successfully validated in both the EMTAB and our clinical validation cohorts. Additionally, the FAMGS serves as an independent risk factor for OS of ccRCC. Results of the immune cell abundance identifier (ImmuCellAI) algorithm and gene set variation analysis (GSVA) revealed that patients in the high-risk group have comprehensively impaired metabolism, including lipids, amino acids and tricarboxylic acid cycle-related pathways and a more immunosuppressive tumor microenvironment. In conclusion, our study constructed and validated a novel FAMGS, which may improve the risk stratification optimization and personalized management of ccRCC." @default.
• W4303946586 created "2022-10-10" @default.
• W4303946586 creator A5003026237 @default.
• W4303946586 creator A5030611214 @default.
• W4303946586 creator A5072676102 @default.
• W4303946586 date "2022-10-09" @default.
• W4303946586 modified "2023-09-26" @default.
• W4303946586 title "A Potential Fatty Acid Metabolism-Related Gene Signature for Prognosis in Clear Cell Renal Cell Carcinoma" @default.
• W4303946586 cites W1910012553 @default.
• W4303946586 cites W1998166655 @default.
• W4303946586 cites W2010457001 @default.
• W4303946586 cites W2021762957 @default.
• W4303946586 cites W2056633943 @default.
• W4303946586 cites W2063746113 @default.
• W4303946586 cites W2097360283 @default.
• W4303946586 cites W2123664981 @default.
• W4303946586 cites W2149199519 @default.
• W4303946586 cites W2159707944 @default.
• W4303946586 cites W2164317031 @default.
• W4303946586 cites W2523687917 @default.
• W4303946586 cites W2613084028 @default.
• W4303946586 cites W2613985230 @default.
• W4303946586 cites W2620920447 @default.
• W4303946586 cites W2726542547 @default.
• W4303946586 cites W2775687989 @default.
• W4303946586 cites W2992324722 @default.
• W4303946586 cites W2993282606 @default.
• W4303946586 cites W3005889306 @default.
• W4303946586 cites W3015450697 @default.
• W4303946586 cites W3020883427 @default.
• W4303946586 cites W3048456013 @default.
• W4303946586 cites W3090735050 @default.
• W4303946586 cites W3093101361 @default.
• W4303946586 cites W3093698317 @default.
• W4303946586 cites W3095456389 @default.
• W4303946586 cites W3122027294 @default.
• W4303946586 cites W3128646645 @default.
• W4303946586 cites W3131861897 @default.
• W4303946586 cites W3137440484 @default.
• W4303946586 cites W3180733422 @default.
• W4303946586 cites W3188736697 @default.
• W4303946586 cites W4200331305 @default.
• W4303946586 cites W4220656304 @default.
• W4303946586 cites W4284880595 @default.
• W4303946586 cites W4294541781 @default.
• W4303946586 doi "https://doi.org/10.3390/cancers14194943" @default.
• W4303946586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36230866" @default.
• W4303946586 hasPublicationYear "2022" @default.
• W4303946586 type Work @default.
• W4303946586 citedByCount "2" @default.
• W4303946586 countsByYear W43039465862022 @default.
• W4303946586 countsByYear W43039465862023 @default.
• W4303946586 crossrefType "journal-article" @default.
• W4303946586 hasAuthorship W4303946586A5003026237 @default.
• W4303946586 hasAuthorship W4303946586A5030611214 @default.
• W4303946586 hasAuthorship W4303946586A5072676102 @default.
• W4303946586 hasBestOaLocation W43039465861 @default.
• W4303946586 hasConcept C126322002 @default.
• W4303946586 hasConcept C143998085 @default.
• W4303946586 hasConcept C2776991927 @default.
• W4303946586 hasConcept C2777472916 @default.
• W4303946586 hasConcept C2781278892 @default.
• W4303946586 hasConcept C50382708 @default.
• W4303946586 hasConcept C60644358 @default.
• W4303946586 hasConcept C62231903 @default.
• W4303946586 hasConcept C71924100 @default.
• W4303946586 hasConcept C72563966 @default.
• W4303946586 hasConcept C86803240 @default.
• W4303946586 hasConceptScore W4303946586C126322002 @default.
• W4303946586 hasConceptScore W4303946586C143998085 @default.
• W4303946586 hasConceptScore W4303946586C2776991927 @default.
• W4303946586 hasConceptScore W4303946586C2777472916 @default.
• W4303946586 hasConceptScore W4303946586C2781278892 @default.
• W4303946586 hasConceptScore W4303946586C50382708 @default.
• W4303946586 hasConceptScore W4303946586C60644358 @default.
• W4303946586 hasConceptScore W4303946586C62231903 @default.
• W4303946586 hasConceptScore W4303946586C71924100 @default.
• W4303946586 hasConceptScore W4303946586C72563966 @default.
• W4303946586 hasConceptScore W4303946586C86803240 @default.
• W4303946586 hasIssue "19" @default.
• W4303946586 hasLocation W43039465861 @default.
• W4303946586 hasLocation W43039465862 @default.
• W4303946586 hasLocation W43039465863 @default.
• W4303946586 hasLocation W43039465864 @default.
• W4303946586 hasOpenAccess W4303946586 @default.
• W4303946586 hasPrimaryLocation W43039465861 @default.
• W4303946586 hasRelatedWork W2160911489 @default.
• W4303946586 hasRelatedWork W2734874846 @default.
• W4303946586 hasRelatedWork W2754810170 @default.
• W4303946586 hasRelatedWork W2791305060 @default.
• W4303946586 hasRelatedWork W3155717659 @default.
• W4303946586 hasRelatedWork W3163846916 @default.
• W4303946586 hasRelatedWork W4205708624 @default.
• W4303946586 hasRelatedWork W4210571220 @default.
• W4303946586 hasRelatedWork W4304808194 @default.
• W4303946586 hasRelatedWork W4311192294 @default.
• W4303946586 hasVolume "14" @default.
• W4303946586 isParatext "false" @default.

• next