FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304013846> ?p ?o ?g. }

• W4304013846 endingPage "e30979" @default.
• W4304013846 startingPage "e30979" @default.
• W4304013846 abstract "Somatic mutations in the oncogenes of the epidermal growth factor receptor signaling pathway play vital roles in colorectal carcinogenesis and have been closely linked with clinical resistance to monoclonal therapy. In this study, we have analyzed the mutation frequencies of 5 genes and compared the genetic findings with clinicopathological variables in order to determine diagnostically relevant alterations and compare these findings with those of other studies In our Sanger sequencings, KRAS (exons 2, 3, and 4), NRAS (exons 2, 3, and 4), PIK3CA (exons 9 and 20), BRAF (exon 15), AKT1 (exon 2) genes, and microsatellite instability (MSI) status were analyzed using an ABI 3500 analyzer in a cohort of 58 Romanian colorectal cancer (CRC) patients who underwent surgical resection at Emergency County Clinical Hospital in Constanța, Romania. In our series, mutation rates of KRAS, BRAF, PIK3CA, and AKT1 genes were 39.63%, 8.62%, 6.88%, and 3.44%, respectively. By contrast, we did not find any tumor harboring mutation in the NRAS gene. Notably, the KRAS and PIK3CA mutations were not mutually exclusive, 1 patient harbored 2 mutations in exon2, codon 12 (Gly12Val) of KRAS and exon 20, codon 1047 (His1047Arg) of PIK3CA. The finding of our study are generally consistent with data found in the literature. Regarding to clinicopathological variables, mutation of KRAS was associated with distant metastasis at the time of diagnosis, while mutation of BRAF was significantly associated with MSI-H in contrast with MSI-L/MSS tumors. Moreover, PIK3CA mutation tends to be located in the proximal segment of the colon and to be well/moderately differentiated compared to wild-type tumors. In conclusion, the assessment of these mutations suggests that CRC patients from southeast Romania exhibit a mutation profile similar to other populations. These results could contribute to creating a better method of qualifying patients for molecularly targeted therapies and obtaining better screening strategies." @default.
• W4304013846 created "2022-10-10" @default.
• W4304013846 creator A5003689043 @default.
• W4304013846 creator A5032855713 @default.
• W4304013846 creator A5043729854 @default.
• W4304013846 creator A5058187046 @default.
• W4304013846 creator A5064632020 @default.
• W4304013846 creator A5084073579 @default.
• W4304013846 creator A5086870373 @default.
• W4304013846 date "2022-10-07" @default.
• W4304013846 modified "2023-10-17" @default.
• W4304013846 title "KRAS, NRAS, BRAF, PIK3CA, and AKT1 signatures in colorectal cancer patients in south-eastern Romania" @default.
• W4304013846 cites W2018023891 @default.
• W4304013846 cites W2043929834 @default.
• W4304013846 cites W2052982012 @default.
• W4304013846 cites W2086808621 @default.
• W4304013846 cites W2112534818 @default.
• W4304013846 cites W2113677807 @default.
• W4304013846 cites W2124662474 @default.
• W4304013846 cites W2129172946 @default.
• W4304013846 cites W2135800465 @default.
• W4304013846 cites W2162886392 @default.
• W4304013846 cites W2164523473 @default.
• W4304013846 cites W2165194477 @default.
• W4304013846 cites W2234879572 @default.
• W4304013846 cites W2272438203 @default.
• W4304013846 cites W2344600572 @default.
• W4304013846 cites W2388163742 @default.
• W4304013846 cites W2463198458 @default.
• W4304013846 cites W2573152477 @default.
• W4304013846 cites W2594604325 @default.
• W4304013846 cites W2950199735 @default.
• W4304013846 cites W2976742560 @default.
• W4304013846 cites W2991472378 @default.
• W4304013846 cites W3002561776 @default.
• W4304013846 cites W3092288892 @default.
• W4304013846 cites W3118800646 @default.
• W4304013846 cites W3194118256 @default.
• W4304013846 cites W4247290180 @default.
• W4304013846 doi "https://doi.org/10.1097/md.0000000000030979" @default.
• W4304013846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36221415" @default.
• W4304013846 hasPublicationYear "2022" @default.
• W4304013846 type Work @default.
• W4304013846 citedByCount "0" @default.
• W4304013846 crossrefType "journal-article" @default.
• W4304013846 hasAuthorship W4304013846A5003689043 @default.
• W4304013846 hasAuthorship W4304013846A5032855713 @default.
• W4304013846 hasAuthorship W4304013846A5043729854 @default.
• W4304013846 hasAuthorship W4304013846A5058187046 @default.
• W4304013846 hasAuthorship W4304013846A5064632020 @default.
• W4304013846 hasAuthorship W4304013846A5084073579 @default.
• W4304013846 hasAuthorship W4304013846A5086870373 @default.
• W4304013846 hasBestOaLocation W43040138461 @default.
• W4304013846 hasConcept C104317684 @default.
• W4304013846 hasConcept C121608353 @default.
• W4304013846 hasConcept C126322002 @default.
• W4304013846 hasConcept C13514818 @default.
• W4304013846 hasConcept C143998085 @default.
• W4304013846 hasConcept C16930146 @default.
• W4304013846 hasConcept C21790070 @default.
• W4304013846 hasConcept C2775922572 @default.
• W4304013846 hasConcept C2779438470 @default.
• W4304013846 hasConcept C2781187634 @default.
• W4304013846 hasConcept C36823959 @default.
• W4304013846 hasConcept C37307934 @default.
• W4304013846 hasConcept C501734568 @default.
• W4304013846 hasConcept C502942594 @default.
• W4304013846 hasConcept C526805850 @default.
• W4304013846 hasConcept C54355233 @default.
• W4304013846 hasConcept C555283112 @default.
• W4304013846 hasConcept C71924100 @default.
• W4304013846 hasConcept C86803240 @default.
• W4304013846 hasConceptScore W4304013846C104317684 @default.
• W4304013846 hasConceptScore W4304013846C121608353 @default.
• W4304013846 hasConceptScore W4304013846C126322002 @default.
• W4304013846 hasConceptScore W4304013846C13514818 @default.
• W4304013846 hasConceptScore W4304013846C143998085 @default.
• W4304013846 hasConceptScore W4304013846C16930146 @default.
• W4304013846 hasConceptScore W4304013846C21790070 @default.
• W4304013846 hasConceptScore W4304013846C2775922572 @default.
• W4304013846 hasConceptScore W4304013846C2779438470 @default.
• W4304013846 hasConceptScore W4304013846C2781187634 @default.
• W4304013846 hasConceptScore W4304013846C36823959 @default.
• W4304013846 hasConceptScore W4304013846C37307934 @default.
• W4304013846 hasConceptScore W4304013846C501734568 @default.
• W4304013846 hasConceptScore W4304013846C502942594 @default.
• W4304013846 hasConceptScore W4304013846C526805850 @default.
• W4304013846 hasConceptScore W4304013846C54355233 @default.
• W4304013846 hasConceptScore W4304013846C555283112 @default.
• W4304013846 hasConceptScore W4304013846C71924100 @default.
• W4304013846 hasConceptScore W4304013846C86803240 @default.
• W4304013846 hasIssue "40" @default.
• W4304013846 hasLocation W43040138461 @default.
• W4304013846 hasLocation W43040138462 @default.
• W4304013846 hasLocation W43040138463 @default.
• W4304013846 hasLocation W43040138464 @default.
• W4304013846 hasOpenAccess W4304013846 @default.
• W4304013846 hasPrimaryLocation W43040138461 @default.

• next