FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304014022> ?p ?o ?g. }

• W4304014022 endingPage "14220" @default.
• W4304014022 startingPage "14201" @default.
• W4304014022 abstract "GLP-1 receptor (GLP-1R) and neuropeptide Y2 receptor (Y2R) dual agonists have shown great potential to treat obesity and type 2 diabetes (T2DM). We developed a multitarget strategy to design monomeric agonists based on Xenopus GLP-1 (xGLP-1) and PYY3-36 analogues with dual activation activities on GLP-1R and Y2R. A novel peptide, 6q, was obtained via stepwise structure optimization and in vitro receptor screens. In db/db and diet-induced obesity (DIO) mice, 6q produced greater effects on long-term glycemic control and body weight reduction than GLP-1R and Y2R monoagonist counterparts. Notably, in high-fat diet-induced nonalcoholic steatohepatitis (NASH) mice, 6q treatment significantly reduced hepatic triglyceride and total cholesterol levels and reversed hepatic steatosis compared with GLP-1R monoagonist (liraglutide) treatment. Collectively, these data support the therapeutic potential of our GLP-1R/Y2R dual agonist 6q as a novel antidiabetic, antiobesity, and antisteatotic agent." @default.
• W4304014022 created "2022-10-10" @default.
• W4304014022 creator A5005026337 @default.
• W4304014022 creator A5009761095 @default.
• W4304014022 creator A5017144750 @default.
• W4304014022 creator A5017669209 @default.
• W4304014022 creator A5018755073 @default.
• W4304014022 creator A5020074350 @default.
• W4304014022 creator A5030494055 @default.
• W4304014022 creator A5039955927 @default.
• W4304014022 creator A5048817096 @default.
• W4304014022 creator A5049978833 @default.
• W4304014022 creator A5054229244 @default.
• W4304014022 creator A5062489099 @default.
• W4304014022 creator A5068273087 @default.
• W4304014022 creator A5077732304 @default.
• W4304014022 creator A5091339708 @default.
• W4304014022 date "2022-10-10" @default.
• W4304014022 modified "2023-10-18" @default.
• W4304014022 title "Design of Xenopus GLP-1-Based Long-Acting Dual GLP-1/Y₂ Receptor Agonists" @default.
• W4304014022 cites W1986331352 @default.
• W4304014022 cites W1986967808 @default.
• W4304014022 cites W1989284914 @default.
• W4304014022 cites W2013184139 @default.
• W4304014022 cites W2028502361 @default.
• W4304014022 cites W2043889992 @default.
• W4304014022 cites W2044300737 @default.
• W4304014022 cites W2050535461 @default.
• W4304014022 cites W2058201576 @default.
• W4304014022 cites W2072109293 @default.
• W4304014022 cites W2077449634 @default.
• W4304014022 cites W2091106363 @default.
• W4304014022 cites W2096227863 @default.
• W4304014022 cites W2107477632 @default.
• W4304014022 cites W2154842844 @default.
• W4304014022 cites W2163710303 @default.
• W4304014022 cites W2608961189 @default.
• W4304014022 cites W2612234120 @default.
• W4304014022 cites W2614940508 @default.
• W4304014022 cites W2730667031 @default.
• W4304014022 cites W2773386259 @default.
• W4304014022 cites W2785139023 @default.
• W4304014022 cites W2797268509 @default.
• W4304014022 cites W2797321538 @default.
• W4304014022 cites W2800843957 @default.
• W4304014022 cites W2811426001 @default.
• W4304014022 cites W2899876501 @default.
• W4304014022 cites W2900829579 @default.
• W4304014022 cites W2900866106 @default.
• W4304014022 cites W2912465744 @default.
• W4304014022 cites W2912933215 @default.
• W4304014022 cites W2915948028 @default.
• W4304014022 cites W2922147515 @default.
• W4304014022 cites W2924479779 @default.
• W4304014022 cites W2948323429 @default.
• W4304014022 cites W2959837219 @default.
• W4304014022 cites W2979558277 @default.
• W4304014022 cites W3012320013 @default.
• W4304014022 cites W3014374030 @default.
• W4304014022 cites W3080703045 @default.
• W4304014022 cites W3095512674 @default.
• W4304014022 cites W3118038259 @default.
• W4304014022 cites W3119030790 @default.
• W4304014022 cites W3121227216 @default.
• W4304014022 cites W3122866315 @default.
• W4304014022 cites W3122953398 @default.
• W4304014022 cites W3212420828 @default.
• W4304014022 cites W3217337816 @default.
• W4304014022 cites W4206445899 @default.
• W4304014022 cites W4225280550 @default.
• W4304014022 doi "https://doi.org/10.1021/acs.jmedchem.2c01385" @default.
• W4304014022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36214844" @default.
• W4304014022 hasPublicationYear "2022" @default.
• W4304014022 type Work @default.
• W4304014022 citedByCount "4" @default.
• W4304014022 countsByYear W43040140222023 @default.
• W4304014022 crossrefType "journal-article" @default.
• W4304014022 hasAuthorship W4304014022A5005026337 @default.
• W4304014022 hasAuthorship W4304014022A5009761095 @default.
• W4304014022 hasAuthorship W4304014022A5017144750 @default.
• W4304014022 hasAuthorship W4304014022A5017669209 @default.
• W4304014022 hasAuthorship W4304014022A5018755073 @default.
• W4304014022 hasAuthorship W4304014022A5020074350 @default.
• W4304014022 hasAuthorship W4304014022A5030494055 @default.
• W4304014022 hasAuthorship W4304014022A5039955927 @default.
• W4304014022 hasAuthorship W4304014022A5048817096 @default.
• W4304014022 hasAuthorship W4304014022A5049978833 @default.
• W4304014022 hasAuthorship W4304014022A5054229244 @default.
• W4304014022 hasAuthorship W4304014022A5062489099 @default.
• W4304014022 hasAuthorship W4304014022A5068273087 @default.
• W4304014022 hasAuthorship W4304014022A5077732304 @default.
• W4304014022 hasAuthorship W4304014022A5091339708 @default.
• W4304014022 hasConcept C126322002 @default.
• W4304014022 hasConcept C134018914 @default.
• W4304014022 hasConcept C170493617 @default.
• W4304014022 hasConcept C185280430 @default.
• W4304014022 hasConcept C185592680 @default.
• W4304014022 hasConcept C2776175330 @default.

• next