Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304014729> ?p ?o ?g. }
- W4304014729 abstract "The aim of this review is to summarize the current understanding of the gut-brain axis (GBA), its impact on neurosurgery, and its implications for future treatment.An abundance of research has established the existence of a collection of pathways between the gut microbiome and the central nervous system (CNS), commonly known as the GBA. Complicating this relationship, the gut microbiome bacterial diversity appears to change with age, antibiotic exposure and a number of external and internal factors.In this paper, we present the current understanding of the key protective and deleterious roles the gut microbiome plays in the pathogenesis of several common neurosurgical concerns.Specifically, we examine how spinal cord injury, traumatic brain injury and stroke may cause gut microbial dysbiosis. Furthermore, this link appears to be bidirectional as gut dysbiosis contributes to secondary CNS injury in each of these ailment settings. This toxic cycle may be broken, and the future secondary damage rescued by timely, therapeutic, gut microbiome modification. In addition, a robust gut microbiome appears to improve outcomes in brain tumour treatment. There are several primary routes by which microbiome dysbiosis may be ameliorated, including faecal microbiota transplant, oral probiotics, bacteriophages, genetic modification of gut microbiota and vagus nerve stimulation.The GBA represents an important component of patient care in the field of neurosurgery. Future research may illuminate ideal methods of therapeutic microbiome modulation in distinct pathogenic settings." @default.
- W4304014729 created "2022-10-10" @default.
- W4304014729 creator A5009672366 @default.
- W4304014729 creator A5020388836 @default.
- W4304014729 creator A5022033420 @default.
- W4304014729 creator A5049256565 @default.
- W4304014729 creator A5050771728 @default.
- W4304014729 creator A5059031404 @default.
- W4304014729 creator A5063574686 @default.
- W4304014729 creator A5067725743 @default.
- W4304014729 creator A5074964521 @default.
- W4304014729 date "2022-10-10" @default.
- W4304014729 modified "2023-10-14" @default.
- W4304014729 title "Gut microbiome and neurosurgery: Implications for treatment" @default.
- W4304014729 cites W1515023627 @default.
- W4304014729 cites W1535379795 @default.
- W4304014729 cites W1557339302 @default.
- W4304014729 cites W1569567729 @default.
- W4304014729 cites W1630693898 @default.
- W4304014729 cites W1663623302 @default.
- W4304014729 cites W1681249975 @default.
- W4304014729 cites W1711618188 @default.
- W4304014729 cites W1716533099 @default.
- W4304014729 cites W1873515901 @default.
- W4304014729 cites W1921871707 @default.
- W4304014729 cites W1971426179 @default.
- W4304014729 cites W1991235944 @default.
- W4304014729 cites W1992526987 @default.
- W4304014729 cites W2002883084 @default.
- W4304014729 cites W2003342633 @default.
- W4304014729 cites W2006517495 @default.
- W4304014729 cites W2010055058 @default.
- W4304014729 cites W2011398156 @default.
- W4304014729 cites W2025082561 @default.
- W4304014729 cites W2030796131 @default.
- W4304014729 cites W2034226385 @default.
- W4304014729 cites W2035408187 @default.
- W4304014729 cites W2036561191 @default.
- W4304014729 cites W2036918186 @default.
- W4304014729 cites W2039047987 @default.
- W4304014729 cites W2061583677 @default.
- W4304014729 cites W2066870378 @default.
- W4304014729 cites W2068234766 @default.
- W4304014729 cites W2076087096 @default.
- W4304014729 cites W2077653833 @default.
- W4304014729 cites W2077868571 @default.
- W4304014729 cites W2079183971 @default.
- W4304014729 cites W2095676088 @default.
- W4304014729 cites W2096160104 @default.
- W4304014729 cites W2096500845 @default.
- W4304014729 cites W2097783355 @default.
- W4304014729 cites W2107414352 @default.
- W4304014729 cites W2107564997 @default.
- W4304014729 cites W2108933323 @default.
- W4304014729 cites W2109113634 @default.
- W4304014729 cites W2111392427 @default.
- W4304014729 cites W2111750491 @default.
- W4304014729 cites W2117727476 @default.
- W4304014729 cites W2123097904 @default.
- W4304014729 cites W2124539308 @default.
- W4304014729 cites W2126422091 @default.
- W4304014729 cites W2130207101 @default.
- W4304014729 cites W2132292972 @default.
- W4304014729 cites W2133211145 @default.
- W4304014729 cites W2139594460 @default.
- W4304014729 cites W2141156676 @default.
- W4304014729 cites W2142536690 @default.
- W4304014729 cites W2142564910 @default.
- W4304014729 cites W2143196592 @default.
- W4304014729 cites W2143523733 @default.
- W4304014729 cites W2145189896 @default.
- W4304014729 cites W2145692836 @default.
- W4304014729 cites W2146409195 @default.
- W4304014729 cites W2146448202 @default.
- W4304014729 cites W2147535506 @default.
- W4304014729 cites W2148171446 @default.
- W4304014729 cites W2150381557 @default.
- W4304014729 cites W2157351620 @default.
- W4304014729 cites W2160353065 @default.
- W4304014729 cites W2161251845 @default.
- W4304014729 cites W2161558877 @default.
- W4304014729 cites W2163940893 @default.
- W4304014729 cites W2164590064 @default.
- W4304014729 cites W2166562121 @default.
- W4304014729 cites W2171605634 @default.
- W4304014729 cites W2178133650 @default.
- W4304014729 cites W2185075416 @default.
- W4304014729 cites W2236166736 @default.
- W4304014729 cites W2238549144 @default.
- W4304014729 cites W2242390630 @default.
- W4304014729 cites W2283538393 @default.
- W4304014729 cites W2284094440 @default.
- W4304014729 cites W2315426300 @default.
- W4304014729 cites W2332044667 @default.
- W4304014729 cites W2338150527 @default.
- W4304014729 cites W2341604280 @default.
- W4304014729 cites W2351998587 @default.
- W4304014729 cites W2401857311 @default.
- W4304014729 cites W2413461190 @default.
- W4304014729 cites W2462451490 @default.