Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304080250> ?p ?o ?g. }
- W4304080250 endingPage "42" @default.
- W4304080250 startingPage "33" @default.
- W4304080250 abstract "Protein-carbohydrate interactions play important roles in various biological processes, such as organism development, cancer metastasis, pathogen infection and immune response, but they remain challenging to study and exploit due to their low binding affinity and non-covalent nature. Here we site-specifically engineered covalent linkages between proteins and carbohydrates under biocompatible conditions. We show that sulfonyl fluoride reacts with glycans via a proximity-enabled reactivity, and to harness this a bioreactive unnatural amino acid (SFY) that contains sulfonyl fluoride was genetically encoded into proteins. SFY-incorporated Siglec-7 crosslinked with its sialoglycan ligand specifically in vitro and on the surface of cancer cells. Through irreversible cloaking of sialoglycan at the cancer cell surface, SFY-incorporated Siglec-7 enhanced the killing of cancer cells by natural killer cells. Genetically encoding the chemical crosslinking of proteins to carbohydrates (GECX-sugar) offers a solution to address the low affinity and weak strength of protein-sugar interactions." @default.
- W4304080250 created "2022-10-10" @default.
- W4304080250 creator A5015623537 @default.
- W4304080250 creator A5033655013 @default.
- W4304080250 creator A5037696066 @default.
- W4304080250 creator A5078600953 @default.
- W4304080250 creator A5084032524 @default.
- W4304080250 date "2022-10-10" @default.
- W4304080250 modified "2023-10-14" @default.
- W4304080250 title "Genetically encoded chemical crosslinking of carbohydrate" @default.
- W4304080250 cites W1966056248 @default.
- W4304080250 cites W1971907885 @default.
- W4304080250 cites W1992660251 @default.
- W4304080250 cites W1997028494 @default.
- W4304080250 cites W1999487949 @default.
- W4304080250 cites W2011489155 @default.
- W4304080250 cites W2012660938 @default.
- W4304080250 cites W2019288241 @default.
- W4304080250 cites W2034933336 @default.
- W4304080250 cites W2034949980 @default.
- W4304080250 cites W2041196497 @default.
- W4304080250 cites W2045950957 @default.
- W4304080250 cites W2059529313 @default.
- W4304080250 cites W2060643327 @default.
- W4304080250 cites W2061377697 @default.
- W4304080250 cites W2069806328 @default.
- W4304080250 cites W2073165848 @default.
- W4304080250 cites W2081796665 @default.
- W4304080250 cites W2093331947 @default.
- W4304080250 cites W2098385260 @default.
- W4304080250 cites W2109436855 @default.
- W4304080250 cites W2117398821 @default.
- W4304080250 cites W2119878439 @default.
- W4304080250 cites W2121953189 @default.
- W4304080250 cites W2131245262 @default.
- W4304080250 cites W2138076568 @default.
- W4304080250 cites W2145468405 @default.
- W4304080250 cites W2158004797 @default.
- W4304080250 cites W2171521392 @default.
- W4304080250 cites W2302510509 @default.
- W4304080250 cites W2329915050 @default.
- W4304080250 cites W2403210488 @default.
- W4304080250 cites W2418946054 @default.
- W4304080250 cites W2469513371 @default.
- W4304080250 cites W2529250862 @default.
- W4304080250 cites W2539722882 @default.
- W4304080250 cites W2766375531 @default.
- W4304080250 cites W2770660331 @default.
- W4304080250 cites W2773265882 @default.
- W4304080250 cites W2795360645 @default.
- W4304080250 cites W2897854020 @default.
- W4304080250 cites W2912191870 @default.
- W4304080250 cites W2941210195 @default.
- W4304080250 cites W2948313296 @default.
- W4304080250 cites W2966215858 @default.
- W4304080250 cites W2982058149 @default.
- W4304080250 cites W3010474975 @default.
- W4304080250 cites W3036688874 @default.
- W4304080250 cites W3084705282 @default.
- W4304080250 cites W3126854145 @default.
- W4304080250 cites W3212437844 @default.
- W4304080250 cites W4236740750 @default.
- W4304080250 doi "https://doi.org/10.1038/s41557-022-01059-z" @default.
- W4304080250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36216893" @default.
- W4304080250 hasPublicationYear "2022" @default.
- W4304080250 type Work @default.
- W4304080250 citedByCount "12" @default.
- W4304080250 countsByYear W43040802502022 @default.
- W4304080250 countsByYear W43040802502023 @default.
- W4304080250 crossrefType "journal-article" @default.
- W4304080250 hasAuthorship W4304080250A5015623537 @default.
- W4304080250 hasAuthorship W4304080250A5033655013 @default.
- W4304080250 hasAuthorship W4304080250A5037696066 @default.
- W4304080250 hasAuthorship W4304080250A5078600953 @default.
- W4304080250 hasAuthorship W4304080250A5084032524 @default.
- W4304080250 hasBestOaLocation W43040802502 @default.
- W4304080250 hasConcept C108625454 @default.
- W4304080250 hasConcept C121608353 @default.
- W4304080250 hasConcept C178790620 @default.
- W4304080250 hasConcept C180577832 @default.
- W4304080250 hasConcept C185592680 @default.
- W4304080250 hasConcept C202751555 @default.
- W4304080250 hasConcept C206212055 @default.
- W4304080250 hasConcept C2778017598 @default.
- W4304080250 hasConcept C2778977261 @default.
- W4304080250 hasConcept C2780758401 @default.
- W4304080250 hasConcept C54355233 @default.
- W4304080250 hasConcept C55493867 @default.
- W4304080250 hasConcept C86803240 @default.
- W4304080250 hasConcept C96232424 @default.
- W4304080250 hasConceptScore W4304080250C108625454 @default.
- W4304080250 hasConceptScore W4304080250C121608353 @default.
- W4304080250 hasConceptScore W4304080250C178790620 @default.
- W4304080250 hasConceptScore W4304080250C180577832 @default.
- W4304080250 hasConceptScore W4304080250C185592680 @default.
- W4304080250 hasConceptScore W4304080250C202751555 @default.
- W4304080250 hasConceptScore W4304080250C206212055 @default.
- W4304080250 hasConceptScore W4304080250C2778017598 @default.