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- W4304080299 abstract "Attention deficit hyperactivity disorder (ADHD) is a major neurodevelopmental disorder including multiple environmental and biological causes. It is generally reported that the prevalence of ADHD is 4-fold higher in boys than in girls. Previous studies have reported that the Y-linked genes have been significantly associated with neuropsychiatric disorders. Furthermore, several Y chromosome haplogroups have been reported to be related to the development of ADHD symptoms. Therefore, we analyzed the genetic correlation between the Y chromosome haplogroups and ADHD in the Korean boys. Our results showed that the Y chromosome haplogroup O2b (xO2b1) (p = 0.053) and O3a3c1 (p = 0.050) has a trend of borderline statistical significance. In subtype analysis, a significant association was observed between haplogroup O3a3c1 and the ADHD/C [odds ratio (OR), 3.43; 95 % confidence interval (CI), 1.336 - 8.782; p = 0.007]. However, this association could not pass the Bonferroni correction for multiple testing. In conclusion, our results showed a lack of association between Y chromosome haplogroups and the occurrence of ADHD in Korean boys." @default.
- W4304080299 created "2022-10-10" @default.
- W4304080299 creator A5009760653 @default.
- W4304080299 creator A5085907787 @default.
- W4304080299 date "2023-01-01" @default.
- W4304080299 modified "2023-10-16" @default.
- W4304080299 title "Lack of association between the Y chromosome haplogroups and attention deficit hyperactivity disorder (ADHD) in Korean boys" @default.
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- W4304080299 doi "https://doi.org/10.1016/j.gene.2022.146954" @default.
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