Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304080339> ?p ?o ?g. }
- W4304080339 endingPage "37970" @default.
- W4304080339 startingPage "37964" @default.
- W4304080339 abstract "Lactoferrin in the saliva is recently considered a biomarker for the diagnosis of Alzheimer's disease. In this paper, a solution-based, user-friendly biosensing system has been developed to quickly measure lactoferrin at low concentrations. This aptasensor is applied to the fluorescence resonance energy transfer (FRET) quenching mechanism, in which carbon quantum dots (CDs) act as the FRET donor; the FRET quenching element is made of graphene oxide (GO) nanosheets which show good quenching capability. CDs bioconjugated with a chosen aptamer (CDs-aptamer) have the strongest emission (λem) at 447 nm when excitation (λex) is 365 nm. Due to the interaction of the aptamer and GO through the π-π* interaction, GO can approach CDs, resulting in FRET quenching. In the presence of lactoferrin, the fluorescence intensity of CDs-aptamer is restored as the binding affinity between lactoferrin and the aptamer is stronger than the π-π* interaction between the aptamer and GO. A linear relationship between the restored fluorescence intensity and the concentration of lactoferrin in artificial saliva with a range from 4 to 16 μg/mL is observed. The limit of detection of the solution-based aptasensor is estimated at 2.48 μg/mL. In addition, the sensing performance of the aptasensor made of carbon nanomaterials has been evaluated to test different proteins including major salivary proteins. The results show that this aptasensor has a high selectivity to detect LF with a low concentration, <16 μg/mL." @default.
- W4304080339 created "2022-10-10" @default.
- W4304080339 creator A5020972239 @default.
- W4304080339 creator A5055204442 @default.
- W4304080339 date "2022-10-10" @default.
- W4304080339 modified "2023-10-16" @default.
- W4304080339 title "Fluorescence Resonance Energy Transfer-Based Aptasensor Made of Carbon-Based Nanomaterials for Detecting Lactoferrin at Low Concentrations" @default.
- W4304080339 cites W1993603706 @default.
- W4304080339 cites W1994976325 @default.
- W4304080339 cites W1999213903 @default.
- W4304080339 cites W2008308116 @default.
- W4304080339 cites W2019081576 @default.
- W4304080339 cites W2030601151 @default.
- W4304080339 cites W2034783449 @default.
- W4304080339 cites W2035680108 @default.
- W4304080339 cites W2048691768 @default.
- W4304080339 cites W2061085356 @default.
- W4304080339 cites W2069683712 @default.
- W4304080339 cites W2082949944 @default.
- W4304080339 cites W2093962378 @default.
- W4304080339 cites W2099973353 @default.
- W4304080339 cites W2161908857 @default.
- W4304080339 cites W2269760464 @default.
- W4304080339 cites W2291688091 @default.
- W4304080339 cites W2520610621 @default.
- W4304080339 cites W2531834066 @default.
- W4304080339 cites W2552828794 @default.
- W4304080339 cites W2563171992 @default.
- W4304080339 cites W2586378363 @default.
- W4304080339 cites W2611458958 @default.
- W4304080339 cites W2617405307 @default.
- W4304080339 cites W2772468670 @default.
- W4304080339 cites W2886271494 @default.
- W4304080339 cites W2887293045 @default.
- W4304080339 cites W2922480329 @default.
- W4304080339 cites W2963845446 @default.
- W4304080339 cites W3017067447 @default.
- W4304080339 cites W3034862929 @default.
- W4304080339 cites W3036497561 @default.
- W4304080339 cites W3073535027 @default.
- W4304080339 cites W3122299217 @default.
- W4304080339 cites W3157657875 @default.
- W4304080339 cites W3185159821 @default.
- W4304080339 cites W3203280260 @default.
- W4304080339 doi "https://doi.org/10.1021/acsomega.2c05129" @default.
- W4304080339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36312380" @default.
- W4304080339 hasPublicationYear "2022" @default.
- W4304080339 type Work @default.
- W4304080339 citedByCount "5" @default.
- W4304080339 countsByYear W43040803392023 @default.
- W4304080339 crossrefType "journal-article" @default.
- W4304080339 hasAuthorship W4304080339A5020972239 @default.
- W4304080339 hasAuthorship W4304080339A5055204442 @default.
- W4304080339 hasBestOaLocation W43040803391 @default.
- W4304080339 hasConcept C119128265 @default.
- W4304080339 hasConcept C120665830 @default.
- W4304080339 hasConcept C121332964 @default.
- W4304080339 hasConcept C121745418 @default.
- W4304080339 hasConcept C128972844 @default.
- W4304080339 hasConcept C138631740 @default.
- W4304080339 hasConcept C160756335 @default.
- W4304080339 hasConcept C171250308 @default.
- W4304080339 hasConcept C185592680 @default.
- W4304080339 hasConcept C192562407 @default.
- W4304080339 hasConcept C2779170986 @default.
- W4304080339 hasConcept C30080830 @default.
- W4304080339 hasConcept C43617362 @default.
- W4304080339 hasConcept C54355233 @default.
- W4304080339 hasConcept C55493867 @default.
- W4304080339 hasConcept C75473681 @default.
- W4304080339 hasConcept C86803240 @default.
- W4304080339 hasConcept C91881484 @default.
- W4304080339 hasConcept C96305047 @default.
- W4304080339 hasConceptScore W4304080339C119128265 @default.
- W4304080339 hasConceptScore W4304080339C120665830 @default.
- W4304080339 hasConceptScore W4304080339C121332964 @default.
- W4304080339 hasConceptScore W4304080339C121745418 @default.
- W4304080339 hasConceptScore W4304080339C128972844 @default.
- W4304080339 hasConceptScore W4304080339C138631740 @default.
- W4304080339 hasConceptScore W4304080339C160756335 @default.
- W4304080339 hasConceptScore W4304080339C171250308 @default.
- W4304080339 hasConceptScore W4304080339C185592680 @default.
- W4304080339 hasConceptScore W4304080339C192562407 @default.
- W4304080339 hasConceptScore W4304080339C2779170986 @default.
- W4304080339 hasConceptScore W4304080339C30080830 @default.
- W4304080339 hasConceptScore W4304080339C43617362 @default.
- W4304080339 hasConceptScore W4304080339C54355233 @default.
- W4304080339 hasConceptScore W4304080339C55493867 @default.
- W4304080339 hasConceptScore W4304080339C75473681 @default.
- W4304080339 hasConceptScore W4304080339C86803240 @default.
- W4304080339 hasConceptScore W4304080339C91881484 @default.
- W4304080339 hasConceptScore W4304080339C96305047 @default.
- W4304080339 hasFunder F4320334593 @default.
- W4304080339 hasIssue "42" @default.
- W4304080339 hasLocation W43040803391 @default.
- W4304080339 hasLocation W43040803392 @default.
- W4304080339 hasLocation W43040803393 @default.
- W4304080339 hasOpenAccess W4304080339 @default.