FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304080416> ?p ?o ?g. }

• W4304080416 endingPage "233" @default.
• W4304080416 startingPage "218" @default.
• W4304080416 abstract "In order to understand the biological processes underlying dopaminergic neurons (DpN) regeneration in a 6-hydroxydopamine(6-OHDA)-induced adult zebrafish-based Parkinson’s disease model, this study investigated the specific phases of neuroregeneration in a time-based manner. Bromodeoxyuridine (BrdU) was administered 24 h before the harvest of brain tissues at day three, five, seven, nine, 12 and 14 postlesion. Potential migration of proliferative cells was tracked over 14 days postlesion through double-pulse tracking [BrdU and 5-ethynyl-2′-deoxyuridine (EdU)] of cells and immunohistostaining of astrocytes [glial fibrillary acidic protein (GFAP)]. Gene expression of foxa2 and nurr1 (nr4a2a) at day three, nine, 14, 18, 22 and 30 postlesion was quantified using qPCR. Protein expression of foxa2 at day three, seven, 14 and 22 postlesion was validated using the western blot technique. Double labelling [EdU and tyrosine hydroxylase (TH)] of proliferative cells was performed to ascertain their fate after the neuroregeneration processes. It was found that whilst cell proliferation remained unchanged in the area of substantial DpN loss, the ventral diencephalon (vDn), there was a transient increase of cell proliferation in the olfactory bulb (OB) and telencephalon (Tel) seven days postlesion. BrdU-immunoreactive (ir)/ EdU-ir cells and activated astrocytes were later found to be significantly increased in the vDn and its nearby area (Tel) 14 days postlesion. There was a significant but transient downregulation of foxa2 at day three and nine postlesion, and nr4a2a at day three, nine and 14 postlesion. The expression of both genes remained unchanged in the OB and Tel. There was a transient downregulation of foxa2 protein expression at day three and seven postlesion. The significant increase of EdU-ir/ TH-ir cells in the vDn 30 days postlesion indicates maturation of proliferative cells (formed between day five-seven postlesion) into DpN. The present findings warrant future investigation of critical factors that govern the distinctive phases of DpN regeneration." @default.
• W4304080416 created "2022-10-10" @default.
• W4304080416 creator A5019522827 @default.
• W4304080416 creator A5022927933 @default.
• W4304080416 creator A5034155183 @default.
• W4304080416 creator A5037109130 @default.
• W4304080416 creator A5068746153 @default.
• W4304080416 creator A5077585324 @default.
• W4304080416 creator A5079568906 @default.
• W4304080416 date "2022-11-01" @default.
• W4304080416 modified "2023-09-26" @default.
• W4304080416 title "Newly regenerated dopaminergic neurons in 6-OHDA-lesioned adult zebrafish brain proliferate in the Olfactory bulb and telencephalon, but migrate to, differentiate and mature in the diencephalon" @default.
• W4304080416 cites W1548483220 @default.
• W4304080416 cites W1594818646 @default.
• W4304080416 cites W1827984733 @default.
• W4304080416 cites W1914434018 @default.
• W4304080416 cites W1964607223 @default.
• W4304080416 cites W1973349931 @default.
• W4304080416 cites W1975420326 @default.
• W4304080416 cites W1976697228 @default.
• W4304080416 cites W1978847014 @default.
• W4304080416 cites W1980142052 @default.
• W4304080416 cites W1981239255 @default.
• W4304080416 cites W1983488393 @default.
• W4304080416 cites W1985645274 @default.
• W4304080416 cites W2011030038 @default.
• W4304080416 cites W2018219363 @default.
• W4304080416 cites W2024167399 @default.
• W4304080416 cites W2035256030 @default.
• W4304080416 cites W2042178048 @default.
• W4304080416 cites W2043306150 @default.
• W4304080416 cites W2047093218 @default.
• W4304080416 cites W2053411111 @default.
• W4304080416 cites W2072500831 @default.
• W4304080416 cites W2074145762 @default.
• W4304080416 cites W2086369996 @default.
• W4304080416 cites W2089699134 @default.
• W4304080416 cites W2094972585 @default.
• W4304080416 cites W2099540110 @default.
• W4304080416 cites W2103272211 @default.
• W4304080416 cites W2103575789 @default.
• W4304080416 cites W2108204976 @default.
• W4304080416 cites W2116309538 @default.
• W4304080416 cites W2132333739 @default.
• W4304080416 cites W2134997228 @default.
• W4304080416 cites W2136898873 @default.
• W4304080416 cites W2138581811 @default.
• W4304080416 cites W2165382565 @default.
• W4304080416 cites W2211392425 @default.
• W4304080416 cites W2269446361 @default.
• W4304080416 cites W2339791932 @default.
• W4304080416 cites W2405736999 @default.
• W4304080416 cites W2408806302 @default.
• W4304080416 cites W2462216989 @default.
• W4304080416 cites W2516233953 @default.
• W4304080416 cites W2559729100 @default.
• W4304080416 cites W2591953949 @default.
• W4304080416 cites W2594731997 @default.
• W4304080416 cites W2727106031 @default.
• W4304080416 cites W2735217796 @default.
• W4304080416 cites W2886197802 @default.
• W4304080416 cites W2953007546 @default.
• W4304080416 cites W2953227834 @default.
• W4304080416 cites W2973267274 @default.
• W4304080416 cites W2996826453 @default.
• W4304080416 cites W3005771705 @default.
• W4304080416 cites W3031790941 @default.
• W4304080416 cites W3046812522 @default.
• W4304080416 cites W3114833400 @default.
• W4304080416 cites W3156893039 @default.
• W4304080416 cites W4200290296 @default.
• W4304080416 cites W4206304567 @default.
• W4304080416 doi "https://doi.org/10.1016/j.brainresbull.2022.10.001" @default.
• W4304080416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36228872" @default.
• W4304080416 hasPublicationYear "2022" @default.
• W4304080416 type Work @default.
• W4304080416 citedByCount "0" @default.
• W4304080416 crossrefType "journal-article" @default.
• W4304080416 hasAuthorship W4304080416A5019522827 @default.
• W4304080416 hasAuthorship W4304080416A5022927933 @default.
• W4304080416 hasAuthorship W4304080416A5034155183 @default.
• W4304080416 hasAuthorship W4304080416A5037109130 @default.
• W4304080416 hasAuthorship W4304080416A5068746153 @default.
• W4304080416 hasAuthorship W4304080416A5077585324 @default.
• W4304080416 hasAuthorship W4304080416A5079568906 @default.
• W4304080416 hasConcept C126322002 @default.
• W4304080416 hasConcept C134018914 @default.
• W4304080416 hasConcept C137183658 @default.
• W4304080416 hasConcept C159167319 @default.
• W4304080416 hasConcept C203014093 @default.
• W4304080416 hasConcept C204232928 @default.
• W4304080416 hasConcept C2775969318 @default.
• W4304080416 hasConcept C2777542381 @default.
• W4304080416 hasConcept C2778260397 @default.
• W4304080416 hasConcept C2780495277 @default.
• W4304080416 hasConcept C2780496858 @default.
• W4304080416 hasConcept C2911016594 @default.
• W4304080416 hasConcept C513476851 @default.

• next