Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304080458> ?p ?o ?g. }
- W4304080458 endingPage "105324" @default.
- W4304080458 startingPage "105324" @default.
- W4304080458 abstract "Efficient delivery of subunit vaccines to dendritic cells (DCs) is necessary to improve vaccine efficacy, because the vaccine antigen alone cannot induce sufficient protective immunity. Here, we identified DC-targeting peptides using a phage display system and demonstrated the potential of these peptides as antigen-delivery carriers to improve subunit vaccine effectiveness in mice. The fusion of antigen proteins and peptides with DC-targeting peptides induced strong antigen-specific IgG responses, even in the absence of adjuvants. In addition, the DC-targeting peptide improved the distribution of antigens to DCs and antigen presentation by DCs. The combined use of an adjuvant with a DC-targeting peptide improved the effectiveness of the vaccine. Furthermore, nucleolin, located on the DC surface, was identified as the receptor for DC-targeting peptide, and nucleolin was indispensable for the vaccine effect of the DC-targeting peptide. Overall, the findings of this study could be useful for developing subunit vaccines against infectious diseases." @default.
- W4304080458 created "2022-10-10" @default.
- W4304080458 creator A5006762365 @default.
- W4304080458 creator A5015381743 @default.
- W4304080458 creator A5032281643 @default.
- W4304080458 creator A5034114161 @default.
- W4304080458 creator A5041280847 @default.
- W4304080458 creator A5041735439 @default.
- W4304080458 creator A5047418888 @default.
- W4304080458 creator A5055027529 @default.
- W4304080458 creator A5056477657 @default.
- W4304080458 creator A5057735595 @default.
- W4304080458 creator A5087815300 @default.
- W4304080458 date "2022-11-01" @default.
- W4304080458 modified "2023-10-14" @default.
- W4304080458 title "Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice" @default.
- W4304080458 cites W111402081 @default.
- W4304080458 cites W1710049236 @default.
- W4304080458 cites W1732892700 @default.
- W4304080458 cites W1808395457 @default.
- W4304080458 cites W1823096434 @default.
- W4304080458 cites W1938515409 @default.
- W4304080458 cites W1946637541 @default.
- W4304080458 cites W1988226150 @default.
- W4304080458 cites W1989658253 @default.
- W4304080458 cites W1991656907 @default.
- W4304080458 cites W1995450305 @default.
- W4304080458 cites W2002761249 @default.
- W4304080458 cites W2011412980 @default.
- W4304080458 cites W2022581009 @default.
- W4304080458 cites W2031154947 @default.
- W4304080458 cites W2039607372 @default.
- W4304080458 cites W2056927031 @default.
- W4304080458 cites W2063541462 @default.
- W4304080458 cites W2075175827 @default.
- W4304080458 cites W2096522270 @default.
- W4304080458 cites W2116763454 @default.
- W4304080458 cites W2121049053 @default.
- W4304080458 cites W2121109850 @default.
- W4304080458 cites W2122718880 @default.
- W4304080458 cites W2124230323 @default.
- W4304080458 cites W2131545125 @default.
- W4304080458 cites W2141391781 @default.
- W4304080458 cites W2153541811 @default.
- W4304080458 cites W2159059319 @default.
- W4304080458 cites W2161684993 @default.
- W4304080458 cites W2162480931 @default.
- W4304080458 cites W2171260203 @default.
- W4304080458 cites W2289160872 @default.
- W4304080458 cites W2301531282 @default.
- W4304080458 cites W2319963189 @default.
- W4304080458 cites W2404096427 @default.
- W4304080458 cites W2405819699 @default.
- W4304080458 cites W2473132821 @default.
- W4304080458 cites W2527863850 @default.
- W4304080458 cites W2564783191 @default.
- W4304080458 cites W2610904923 @default.
- W4304080458 cites W2721821765 @default.
- W4304080458 cites W2738277181 @default.
- W4304080458 cites W2765418773 @default.
- W4304080458 cites W2766886140 @default.
- W4304080458 cites W2775374952 @default.
- W4304080458 cites W2782708334 @default.
- W4304080458 cites W2803108440 @default.
- W4304080458 cites W2803559194 @default.
- W4304080458 cites W2894112953 @default.
- W4304080458 cites W2895493756 @default.
- W4304080458 cites W2901221545 @default.
- W4304080458 cites W2901699313 @default.
- W4304080458 cites W2903412596 @default.
- W4304080458 cites W2919790473 @default.
- W4304080458 cites W2925337251 @default.
- W4304080458 cites W2925445693 @default.
- W4304080458 cites W2963129387 @default.
- W4304080458 cites W2992070886 @default.
- W4304080458 cites W3005609359 @default.
- W4304080458 cites W3011228674 @default.
- W4304080458 cites W3038037714 @default.
- W4304080458 cites W3092344067 @default.
- W4304080458 cites W3155031226 @default.
- W4304080458 cites W3166404219 @default.
- W4304080458 cites W3176649308 @default.
- W4304080458 cites W3183690105 @default.
- W4304080458 cites W3199804231 @default.
- W4304080458 cites W4206384730 @default.
- W4304080458 doi "https://doi.org/10.1016/j.isci.2022.105324" @default.
- W4304080458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36304121" @default.
- W4304080458 hasPublicationYear "2022" @default.
- W4304080458 type Work @default.
- W4304080458 citedByCount "0" @default.
- W4304080458 crossrefType "journal-article" @default.
- W4304080458 hasAuthorship W4304080458A5006762365 @default.
- W4304080458 hasAuthorship W4304080458A5015381743 @default.
- W4304080458 hasAuthorship W4304080458A5032281643 @default.
- W4304080458 hasAuthorship W4304080458A5034114161 @default.
- W4304080458 hasAuthorship W4304080458A5041280847 @default.
- W4304080458 hasAuthorship W4304080458A5041735439 @default.
- W4304080458 hasAuthorship W4304080458A5047418888 @default.