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- W4304080767 abstract "Direct oral anticoagulants (DOACs) represent a significant advance over vitamin K antagonists, such as warfarin in patients with atrial fibrillation (AF), due to their favorable risk-benefit profile, with significant reductions in stroke and serious bleeding, particularly intracranial hemorrhage.1 Although as class, DOACs tend to reduce major bleeding in general compared to warfarin, they are associated with a significant excess of gastrointestinal (GI) bleeding. A rationale for this observation is that unlike warfarin, the DOACs are active anticoagulants in the gastrointestinal lumen which contributes to GI bleeding above and beyond the systemic exposure to anticoagulant activity. Ido et al. present an interesting study in this issue investigating whether dosing regimen, specifically once vs. twice daily, is the major contributor to a differential GI bleeding profile across the DOACs." @default.
- W4304080767 created "2022-10-10" @default.
- W4304080767 creator A5016322021 @default.
- W4304080767 date "2022-11-01" @default.
- W4304080767 modified "2023-09-26" @default.
- W4304080767 title "The importance of dosing frequency on the safety of DOACs" @default.
- W4304080767 cites W2096246254 @default.
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- W4304080767 doi "https://doi.org/10.1016/j.ahjo.2022.100216" @default.
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