FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304086136> ?p ?o ?g. }

• W4304086136 endingPage "e1009945" @default.
• W4304086136 startingPage "e1009945" @default.
• W4304086136 abstract "Obsessive-compulsive disorder (OCD) is characterized by uncontrollable repetitive actions thought to rely on abnormalities within fundamental instrumental learning systems. We investigated cognitive and computational mechanisms underlying Pavlovian biases on instrumental behavior in both clinical OCD patients and healthy controls using a Pavlovian-Instrumental Transfer (PIT) task. PIT is typically evidenced by increased responding in the presence of a positive (previously rewarded) Pavlovian cue, and reduced responding in the presence of a negative cue. Thirty OCD patients and thirty-one healthy controls completed the Pavlovian Instrumental Transfer test, which included instrumental training, Pavlovian training for positive, negative and neutral cues, and a PIT phase in which participants performed the instrumental task in the presence of the Pavlovian cues. Modified Rescorla-Wagner models were fitted to trial-by-trial data of participants to estimate underlying computational mechanism and quantify individual differences during training and transfer stages. Bayesian hierarchical methods were used to estimate free parameters and compare the models. Behavioral and computational results indicated a weaker Pavlovian influence on instrumental behavior in OCD patients than in HC, especially for negative Pavlovian cues. Our results contrast with the increased PIT effects reported for another set of disorders characterized by compulsivity, substance use disorders, in which PIT is enhanced. A possible reason for the reduced PIT in OCD may be impairment in using the contextual information provided by the cues to appropriately adjust behavior, especially when inhibiting responding when a negative cue is present. This study provides deeper insight into our understanding of deficits in OCD from the perspective of Pavlovian influences on instrumental behavior and may have implications for OCD treatment modalities focused on reducing compulsive behaviors." @default.
• W4304086136 created "2022-10-10" @default.
• W4304086136 creator A5013323320 @default.
• W4304086136 creator A5038994202 @default.
• W4304086136 creator A5054766869 @default.
• W4304086136 creator A5057643497 @default.
• W4304086136 creator A5058477270 @default.
• W4304086136 creator A5075648249 @default.
• W4304086136 date "2022-10-10" @default.
• W4304086136 modified "2023-09-25" @default.
• W4304086136 title "Obsessive-compulsive disorder is characterized by decreased Pavlovian influence on instrumental behavior" @default.
• W4304086136 cites W1545740572 @default.
• W4304086136 cites W1968171663 @default.
• W4304086136 cites W1969707662 @default.
• W4304086136 cites W1974055608 @default.
• W4304086136 cites W1979240561 @default.
• W4304086136 cites W1980377083 @default.
• W4304086136 cites W1980506405 @default.
• W4304086136 cites W1982923114 @default.
• W4304086136 cites W1994834951 @default.
• W4304086136 cites W2000226539 @default.
• W4304086136 cites W2008005549 @default.
• W4304086136 cites W2016434222 @default.
• W4304086136 cites W2061257589 @default.
• W4304086136 cites W2076230795 @default.
• W4304086136 cites W2083607057 @default.
• W4304086136 cites W2103897634 @default.
• W4304086136 cites W2105112885 @default.
• W4304086136 cites W2110309242 @default.
• W4304086136 cites W2115044393 @default.
• W4304086136 cites W2115344935 @default.
• W4304086136 cites W2115940856 @default.
• W4304086136 cites W2118907350 @default.
• W4304086136 cites W2123822033 @default.
• W4304086136 cites W2124726460 @default.
• W4304086136 cites W2132189191 @default.
• W4304086136 cites W2132598305 @default.
• W4304086136 cites W2133351239 @default.
• W4304086136 cites W2142586783 @default.
• W4304086136 cites W2146676986 @default.
• W4304086136 cites W2161231549 @default.
• W4304086136 cites W2162661917 @default.
• W4304086136 cites W2169323873 @default.
• W4304086136 cites W2197119601 @default.
• W4304086136 cites W2271338358 @default.
• W4304086136 cites W2527291499 @default.
• W4304086136 cites W2561208860 @default.
• W4304086136 cites W2617332934 @default.
• W4304086136 cites W2625337450 @default.
• W4304086136 cites W2697296723 @default.
• W4304086136 cites W2740903838 @default.
• W4304086136 cites W2752128106 @default.
• W4304086136 cites W2885477424 @default.
• W4304086136 cites W2894589877 @default.
• W4304086136 cites W2903740291 @default.
• W4304086136 cites W2904117745 @default.
• W4304086136 cites W2935509564 @default.
• W4304086136 cites W2946003979 @default.
• W4304086136 cites W2950659873 @default.
• W4304086136 cites W2952217114 @default.
• W4304086136 cites W2954874978 @default.
• W4304086136 cites W2961283751 @default.
• W4304086136 cites W2964151936 @default.
• W4304086136 cites W2982308961 @default.
• W4304086136 cites W2985500068 @default.
• W4304086136 cites W2995557889 @default.
• W4304086136 cites W3010778588 @default.
• W4304086136 cites W3013064929 @default.
• W4304086136 cites W3015366503 @default.
• W4304086136 cites W3043772263 @default.
• W4304086136 cites W3128940418 @default.
• W4304086136 cites W3171418018 @default.
• W4304086136 cites W3172071485 @default.
• W4304086136 cites W4200422748 @default.
• W4304086136 doi "https://doi.org/10.1371/journal.pcbi.1009945" @default.
• W4304086136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36215326" @default.
• W4304086136 hasPublicationYear "2022" @default.
• W4304086136 type Work @default.
• W4304086136 citedByCount "0" @default.
• W4304086136 crossrefType "journal-article" @default.
• W4304086136 hasAuthorship W4304086136A5013323320 @default.
• W4304086136 hasAuthorship W4304086136A5038994202 @default.
• W4304086136 hasAuthorship W4304086136A5054766869 @default.
• W4304086136 hasAuthorship W4304086136A5057643497 @default.
• W4304086136 hasAuthorship W4304086136A5058477270 @default.
• W4304086136 hasAuthorship W4304086136A5075648249 @default.
• W4304086136 hasBestOaLocation W43040861361 @default.
• W4304086136 hasConcept C12713177 @default.
• W4304086136 hasConcept C138496976 @default.
• W4304086136 hasConcept C154945302 @default.
• W4304086136 hasConcept C15744967 @default.
• W4304086136 hasConcept C169760540 @default.
• W4304086136 hasConcept C169900460 @default.
• W4304086136 hasConcept C177264268 @default.
• W4304086136 hasConcept C180747234 @default.
• W4304086136 hasConcept C199360897 @default.
• W4304086136 hasConcept C41008148 @default.
• W4304086136 hasConceptScore W4304086136C12713177 @default.

• next