FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304092522> ?p ?o ?g. }

• W4304092522 endingPage "101697" @default.
• W4304092522 startingPage "101697" @default.
• W4304092522 abstract "The promising protective effect of Urtica dioica (U. dioica) extract on different organs' injuries is well established. Nevertheless, its ameliorative activity against cerebral ischemia (stroke) has not yet been clearly evaluated. As such, this study was designed to explore the probable neuroprotective activity of U. dioica on neurological deficit score (NDS), infarct volume (IV) and gene expression of caspase-3 and cyclooxygenases-2 (COX-2) in a rat model of stroke. In this study, twenty-four Wistar rats were randomly arranged into three groups: (1) intact, (2) Middle cerebral artery occlusion (MCAO) control and (3) MCAO + U. dioica (100 mg/kg; daily intraperitoneal (IP) injection for 7 days until one day before induction of MCAO). After 24-h reperfusion, NDS was measured and then the brain tissues were isolated to determine the IV and the mRNA level of COX-2 and caspase-3 genes by 2,3,5-triphenyltetrazolium chloride (TTC)-staining and Real time PCR techniques, respectively. The results showed that pretreatment with U. dioica considerably decreased the NDS and IV in the core, penumbra and subcortex of MCAO-induced rats regarding MCAO rats (P < 0.05). Also, the mRNA level of caspase-3 in the all-mentioned areas of brain was markedly diminished in the U. dioica-treated group in comparison with the MCAO group (P < 0.05). However, COX-2 gene expression was elevated in the subcortex area of MCAO and U. dioica rats in comparison to the intact rats (P < 0.05). Overall, pretreatment with U. dioica might mitigate brain injury after ischemic stroke, most probably by regulating caspase-3 and COX-2 genes expression." @default.
• W4304092522 created "2022-10-10" @default.
• W4304092522 creator A5012729776 @default.
• W4304092522 creator A5070024946 @default.
• W4304092522 creator A5082469493 @default.
• W4304092522 date "2022-12-01" @default.
• W4304092522 modified "2023-09-29" @default.
• W4304092522 title "Effects of Urtica dioica extract on caspase-3 and cyclooxygenase-2 genes expression in a rat stroke model" @default.
• W4304092522 cites W1128062319 @default.
• W4304092522 cites W1971004207 @default.
• W4304092522 cites W1988086690 @default.
• W4304092522 cites W2013368296 @default.
• W4304092522 cites W2017082833 @default.
• W4304092522 cites W2027186018 @default.
• W4304092522 cites W2062012556 @default.
• W4304092522 cites W2080236116 @default.
• W4304092522 cites W2083476138 @default.
• W4304092522 cites W2108238225 @default.
• W4304092522 cites W2112505121 @default.
• W4304092522 cites W2121793916 @default.
• W4304092522 cites W2151040397 @default.
• W4304092522 cites W2213746779 @default.
• W4304092522 cites W2214448147 @default.
• W4304092522 cites W2466600378 @default.
• W4304092522 cites W2481191309 @default.
• W4304092522 cites W2622249127 @default.
• W4304092522 cites W2802116803 @default.
• W4304092522 cites W2808869593 @default.
• W4304092522 cites W2809801003 @default.
• W4304092522 cites W2890256657 @default.
• W4304092522 cites W2891298462 @default.
• W4304092522 cites W2954245732 @default.
• W4304092522 cites W2962860949 @default.
• W4304092522 cites W2964766782 @default.
• W4304092522 cites W3006485780 @default.
• W4304092522 cites W3012684581 @default.
• W4304092522 cites W3081530390 @default.
• W4304092522 cites W3085242129 @default.
• W4304092522 cites W3094426257 @default.
• W4304092522 cites W3094461118 @default.
• W4304092522 cites W3176422621 @default.
• W4304092522 cites W4213072850 @default.
• W4304092522 cites W4240392667 @default.
• W4304092522 cites W4280611594 @default.
• W4304092522 cites W2940333534 @default.
• W4304092522 doi "https://doi.org/10.1016/j.genrep.2022.101697" @default.
• W4304092522 hasPublicationYear "2022" @default.
• W4304092522 type Work @default.
• W4304092522 citedByCount "0" @default.
• W4304092522 crossrefType "journal-article" @default.
• W4304092522 hasAuthorship W4304092522A5012729776 @default.
• W4304092522 hasAuthorship W4304092522A5070024946 @default.
• W4304092522 hasAuthorship W4304092522A5082469493 @default.
• W4304092522 hasConcept C126322002 @default.
• W4304092522 hasConcept C127413603 @default.
• W4304092522 hasConcept C134018914 @default.
• W4304092522 hasConcept C185592680 @default.
• W4304092522 hasConcept C190283241 @default.
• W4304092522 hasConcept C25498285 @default.
• W4304092522 hasConcept C2779964429 @default.
• W4304092522 hasConcept C2780577055 @default.
• W4304092522 hasConcept C2780645631 @default.
• W4304092522 hasConcept C541997718 @default.
• W4304092522 hasConcept C55493867 @default.
• W4304092522 hasConcept C556039675 @default.
• W4304092522 hasConcept C71924100 @default.
• W4304092522 hasConcept C78519656 @default.
• W4304092522 hasConcept C98274493 @default.
• W4304092522 hasConceptScore W4304092522C126322002 @default.
• W4304092522 hasConceptScore W4304092522C127413603 @default.
• W4304092522 hasConceptScore W4304092522C134018914 @default.
• W4304092522 hasConceptScore W4304092522C185592680 @default.
• W4304092522 hasConceptScore W4304092522C190283241 @default.
• W4304092522 hasConceptScore W4304092522C25498285 @default.
• W4304092522 hasConceptScore W4304092522C2779964429 @default.
• W4304092522 hasConceptScore W4304092522C2780577055 @default.
• W4304092522 hasConceptScore W4304092522C2780645631 @default.
• W4304092522 hasConceptScore W4304092522C541997718 @default.
• W4304092522 hasConceptScore W4304092522C55493867 @default.
• W4304092522 hasConceptScore W4304092522C556039675 @default.
• W4304092522 hasConceptScore W4304092522C71924100 @default.
• W4304092522 hasConceptScore W4304092522C78519656 @default.
• W4304092522 hasConceptScore W4304092522C98274493 @default.
• W4304092522 hasFunder F4320323304 @default.
• W4304092522 hasLocation W43040925221 @default.
• W4304092522 hasOpenAccess W4304092522 @default.
• W4304092522 hasPrimaryLocation W43040925221 @default.
• W4304092522 hasRelatedWork W2053137874 @default.
• W4304092522 hasRelatedWork W2092761039 @default.
• W4304092522 hasRelatedWork W2141652787 @default.
• W4304092522 hasRelatedWork W2314530543 @default.
• W4304092522 hasRelatedWork W2356714908 @default.
• W4304092522 hasRelatedWork W2386233880 @default.
• W4304092522 hasRelatedWork W2748952813 @default.
• W4304092522 hasRelatedWork W3029582907 @default.
• W4304092522 hasRelatedWork W3110995456 @default.
• W4304092522 hasRelatedWork W55434504 @default.
• W4304092522 hasVolume "29" @default.

• next