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• W4304098647 abstract "MHC molecules are not randomly distributed on the plasma membrane but instead are present in discrete nanoclusters. The mechanisms that control formation of MHC I nanoclusters and the importance of such structures are incompletely understood. Here, we report a molecular association between tetraspanin-5 (Tspan5) and MHC I molecules that started in the endoplasmic reticulum and was maintained on the plasma membrane. This association was observed both in mouse dendritic cells and in human cancer cell lines. Loss of Tspan5 reduced the size of MHC I clusters without affecting MHC I peptide loading, delivery of complexes to the plasma membrane, or overall surface MHC I levels. Functionally, CD8 T cell responses to antigen presented by Tspan5-deficient dendritic cells were impaired but were restored by antibody-induced reclustering of MHC I molecules. In contrast, Tspan5 did not associate with two other plasma membrane proteins, Flotillin1 and CD55, with or the endoplasmic reticulum proteins Tapasin and TAP. Thus, our findings identify a mechanism underlying the clustering of MHC I molecules that is important for optimal T cell responses." @default.
• W4304098647 created "2022-10-10" @default.
• W4304098647 creator A5062673144 @default.
• W4304098647 creator A5082096834 @default.
• W4304098647 creator A5084189973 @default.
• W4304098647 creator A5090361265 @default.
• W4304098647 date "2022-10-10" @default.
• W4304098647 modified "2023-10-10" @default.
• W4304098647 title "Tetraspanin-5–mediated MHC class I clustering is required for optimal CD8 T cell activation" @default.
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• W4304098647 doi "https://doi.org/10.1073/pnas.2122188119" @default.
• W4304098647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36215490" @default.
• W4304098647 hasPublicationYear "2022" @default.
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• W4304098647 hasAuthorship W4304098647A5062673144 @default.
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• W4304098647 hasAuthorship W4304098647A5084189973 @default.

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