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• W4304118601 abstract "Microtubules typically promote nuclear centring during early embryonic divisions in centrosome-containing vertebrates. In acentrosomal mouse zygotes, microtubules also centre male and female pronuclei prior to the first mitosis, this time in concert with actin. How nuclear centring is brought about in subsequent acentrosomal embryonic divisions has not been studied. Here, using time-lapse imaging in mouse embryos, we find that although nuclei are delivered to the cell centre upon completion of the first mitotic anaphase, the majority do not remain stationary and instead travel all the way to the cortex in a microtubule-dependent manner. High cytoplasmic viscosity in 2-cell embryos is associated with non-diffusive mechanisms involving actin for subsequent nuclear centring when microtubules again exert a negative influence. Thus, following the first mitotic division, pro-centring actin-dependent mechanisms work against microtubule-dependent de-centring forces. Disrupting the equilibrium of this tug-of-war compromises nuclear centring and symmetry of the subsequent division potentially risking embryonic development. This circuitous centring process exposes an embryonic vulnerability imposed by microtubule-dependent de-centring forces." @default.
• W4304118601 created "2022-10-11" @default.
• W4304118601 creator A5004603031 @default.
• W4304118601 creator A5044209781 @default.
• W4304118601 date "2022-10-10" @default.
• W4304118601 modified "2023-10-17" @default.
• W4304118601 title "Two‐step nuclear centring by competing microtubule‐ and actin‐based mechanisms in 2‐cell mouse embryos" @default.
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• W4304118601 doi "https://doi.org/10.15252/embr.202255251" @default.
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• W4304118601 hasPublicationYear "2022" @default.
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