FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304127875> ?p ?o ?g. }

• W4304127875 endingPage "2002" @default.
• W4304127875 startingPage "2002" @default.
• W4304127875 abstract "In this study, we evaluated the protective effects and potential mechanisms of acidifiers on intestinal epithelial cells exposure to oxidative stress (OS). IPEC-J2 cells were first pretreated with 5 × 10−5 acidifiers for 4 h before being exposed to the optimal dose of diquat to induce oxidative stress. The results showed that acidifiers attenuated diquat-induced oxidative stress, which manifests as the improvement of antioxidant capacity and the reduction in reactive oxygen species (ROS) accumulation. The acidifier treatment decreased cell permeability and enhanced intestinal epithelial barrier function through enhancing the expression of claudin-1 and occludin in diquat-induced cells. Moreover, acidifier treatment attenuated diquat-induced inflammatory responses, which was confirmed by the decreased secretion and gene expression of pro-inflammatory (TNF-α, IL-8) and upregulated anti-inflammatory factors (IL-10). In addition, acidifiers significantly reduced the diquat-induced gene and protein expression levels of COX-2, NF-κB, I-κB-β, ERK1/2, and JNK2, while they increased I-κB-α expression in IPEC-J2 cells. Furthermore, we discovered that acidifiers promoted epithelial cell proliferation (increased expression of PCNA and CCND1) and inhibited apoptosis (decreased expression of BAX, increased expression of BCL-2). Taken together, these results suggest that acidifiers are potent antioxidants that attenuate diquat-induced inflammation, apoptosis, and maintain cellular barrier integrity by regulating the NF-κB/MAPK/COX-2 signaling pathways." @default.
• W4304127875 created "2022-10-11" @default.
• W4304127875 creator A5023874417 @default.
• W4304127875 creator A5039620313 @default.
• W4304127875 creator A5054169128 @default.
• W4304127875 creator A5054288577 @default.
• W4304127875 creator A5059161200 @default.
• W4304127875 creator A5072071140 @default.
• W4304127875 creator A5085325774 @default.
• W4304127875 creator A5088059015 @default.
• W4304127875 date "2022-10-10" @default.
• W4304127875 modified "2023-09-25" @default.
• W4304127875 title "Acidifiers Attenuate Diquat-Induced Oxidative Stress and Inflammatory Responses by Regulating NF-κB/MAPK/COX-2 Pathways in IPEC-J2 Cells" @default.
• W4304127875 cites W1556307824 @default.
• W4304127875 cites W1969437476 @default.
• W4304127875 cites W2000013493 @default.
• W4304127875 cites W2002483552 @default.
• W4304127875 cites W2027616336 @default.
• W4304127875 cites W2040253089 @default.
• W4304127875 cites W2042157149 @default.
• W4304127875 cites W2050969183 @default.
• W4304127875 cites W2056553092 @default.
• W4304127875 cites W2056752509 @default.
• W4304127875 cites W2067810642 @default.
• W4304127875 cites W2077269712 @default.
• W4304127875 cites W2097005995 @default.
• W4304127875 cites W2107277218 @default.
• W4304127875 cites W2111110000 @default.
• W4304127875 cites W2132530208 @default.
• W4304127875 cites W2132933922 @default.
• W4304127875 cites W2141109742 @default.
• W4304127875 cites W2143541289 @default.
• W4304127875 cites W2168173455 @default.
• W4304127875 cites W2192080449 @default.
• W4304127875 cites W2418027028 @default.
• W4304127875 cites W2460193803 @default.
• W4304127875 cites W2485997503 @default.
• W4304127875 cites W2508458851 @default.
• W4304127875 cites W2552375562 @default.
• W4304127875 cites W2592326108 @default.
• W4304127875 cites W2605388267 @default.
• W4304127875 cites W2730479429 @default.
• W4304127875 cites W2772411715 @default.
• W4304127875 cites W2777277663 @default.
• W4304127875 cites W2791757297 @default.
• W4304127875 cites W2792930912 @default.
• W4304127875 cites W2886469844 @default.
• W4304127875 cites W2898680497 @default.
• W4304127875 cites W2903406988 @default.
• W4304127875 cites W2917960454 @default.
• W4304127875 cites W2965730099 @default.
• W4304127875 cites W2982439156 @default.
• W4304127875 cites W2988009907 @default.
• W4304127875 cites W2993223434 @default.
• W4304127875 cites W3001440350 @default.
• W4304127875 cites W3005068436 @default.
• W4304127875 cites W3012014464 @default.
• W4304127875 cites W3012678778 @default.
• W4304127875 cites W3018128986 @default.
• W4304127875 cites W3022473039 @default.
• W4304127875 cites W3023076996 @default.
• W4304127875 cites W3028453605 @default.
• W4304127875 cites W3031664260 @default.
• W4304127875 cites W3041934953 @default.
• W4304127875 cites W3048372430 @default.
• W4304127875 cites W3081542391 @default.
• W4304127875 cites W3113926219 @default.
• W4304127875 cites W3166219587 @default.
• W4304127875 cites W3173593921 @default.
• W4304127875 cites W3186276387 @default.
• W4304127875 cites W3191300367 @default.
• W4304127875 cites W3193943363 @default.
• W4304127875 cites W3201025222 @default.
• W4304127875 cites W3203184227 @default.
• W4304127875 cites W3206741497 @default.
• W4304127875 cites W3208000735 @default.
• W4304127875 cites W3209534596 @default.
• W4304127875 cites W4205604443 @default.
• W4304127875 cites W4220985942 @default.
• W4304127875 cites W4224239147 @default.
• W4304127875 cites W4229077730 @default.
• W4304127875 cites W4378602689 @default.
• W4304127875 doi "https://doi.org/10.3390/antiox11102002" @default.
• W4304127875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36290726" @default.
• W4304127875 hasPublicationYear "2022" @default.
• W4304127875 type Work @default.
• W4304127875 citedByCount "1" @default.
• W4304127875 countsByYear W43041278752023 @default.
• W4304127875 crossrefType "journal-article" @default.
• W4304127875 hasAuthorship W4304127875A5023874417 @default.
• W4304127875 hasAuthorship W4304127875A5039620313 @default.
• W4304127875 hasAuthorship W4304127875A5054169128 @default.
• W4304127875 hasAuthorship W4304127875A5054288577 @default.
• W4304127875 hasAuthorship W4304127875A5059161200 @default.
• W4304127875 hasAuthorship W4304127875A5072071140 @default.
• W4304127875 hasAuthorship W4304127875A5085325774 @default.
• W4304127875 hasAuthorship W4304127875A5088059015 @default.
• W4304127875 hasBestOaLocation W43041278751 @default.

• next