FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304128182> ?p ?o ?g. }

• W4304128182 endingPage "107032" @default.
• W4304128182 startingPage "107032" @default.
• W4304128182 abstract "The development and propagation of seizure-related activity was studied in piriform cortex (PC) and areas in the medial temporal lobe to which it projects. In the urethane anesthetized adult rat at normal body temperature, tiny injections of convulsants in anterior PC (APC) generate an epileptogenic zone (focus) that can recruit electrographic seizures in untreated posterior PC (PPC) when bursts in the focus are paced at delta frequency (1-4 Hz) by stimulating the lateral olfactory tract. Epileptiform activity initiated by this 'paced-recruitment' procedure propagates throughout PPC and into other areas involved in mesial temporal lobe epilepsy (mTLE) at an exceedingly low velocity (< 1 mm/sec) as reported for focal seizures in human cortex. Proconvulsants increased the probability of recruiting electrographic seizures relative to disinhibiting agents that typically recruited interictal discharges. Through methods including realtime recording of current source-density (CSD) with vertical 22-site silicon-based electrodes, and membrane potential with transmembrane microelectrode pairs, insights were gained into mechanisms for epileptogenesis from PC. These findings also may apply to seizure initiation from epileptogenic zones in other areas that project to PPC in addition to APC. Findings from surgical studies indicating that PC plays a critical role in mTLE suggest that the results may be relevant to finding new approaches for blocking seizures from this common, virulent form of epilepsy. Immediate implications for treatment include the optimal placement and patterning of deep brain stimulation to increase its effectiveness for blocking seizures from mTLE while reducing the risk to vasculature from direct stimulation of PC." @default.
• W4304128182 created "2022-10-11" @default.
• W4304128182 creator A5051312534 @default.
• W4304128182 date "2022-11-01" @default.
• W4304128182 modified "2023-09-29" @default.
• W4304128182 title "Recruitment of interictal- and ictal-like discharges in posterior piriform cortex by delta-rate (1–4 Hz) focal bursts in anterior piriform cortex in vivo" @default.
• W4304128182 cites W1492983361 @default.
• W4304128182 cites W1503935526 @default.
• W4304128182 cites W1536357320 @default.
• W4304128182 cites W1556910214 @default.
• W4304128182 cites W1609394567 @default.
• W4304128182 cites W1808344492 @default.
• W4304128182 cites W1891543180 @default.
• W4304128182 cites W1964660650 @default.
• W4304128182 cites W1965461706 @default.
• W4304128182 cites W1968028223 @default.
• W4304128182 cites W1973119090 @default.
• W4304128182 cites W1973426426 @default.
• W4304128182 cites W1975158852 @default.
• W4304128182 cites W1977504069 @default.
• W4304128182 cites W1979904784 @default.
• W4304128182 cites W1981082198 @default.
• W4304128182 cites W1985772031 @default.
• W4304128182 cites W1986025484 @default.
• W4304128182 cites W1987211298 @default.
• W4304128182 cites W1992147695 @default.
• W4304128182 cites W1992785020 @default.
• W4304128182 cites W1998274485 @default.
• W4304128182 cites W2000908815 @default.
• W4304128182 cites W2002383211 @default.
• W4304128182 cites W2002608596 @default.
• W4304128182 cites W2010806059 @default.
• W4304128182 cites W2015941198 @default.
• W4304128182 cites W2016429665 @default.
• W4304128182 cites W2017783331 @default.
• W4304128182 cites W2026153752 @default.
• W4304128182 cites W2026623769 @default.
• W4304128182 cites W2027056961 @default.
• W4304128182 cites W2031003452 @default.
• W4304128182 cites W2031917286 @default.
• W4304128182 cites W2043837133 @default.
• W4304128182 cites W2046361252 @default.
• W4304128182 cites W2049268334 @default.
• W4304128182 cites W2055568369 @default.
• W4304128182 cites W2056571308 @default.
• W4304128182 cites W2058256400 @default.
• W4304128182 cites W2058940518 @default.
• W4304128182 cites W2069328624 @default.
• W4304128182 cites W2076695229 @default.
• W4304128182 cites W2077116732 @default.
• W4304128182 cites W2079725109 @default.
• W4304128182 cites W2084694708 @default.
• W4304128182 cites W2086781134 @default.
• W4304128182 cites W2092533498 @default.
• W4304128182 cites W2092815508 @default.
• W4304128182 cites W2102339248 @default.
• W4304128182 cites W2107349924 @default.
• W4304128182 cites W2107490666 @default.
• W4304128182 cites W2108809409 @default.
• W4304128182 cites W2109674931 @default.
• W4304128182 cites W2111265038 @default.
• W4304128182 cites W2116273500 @default.
• W4304128182 cites W2116892960 @default.
• W4304128182 cites W2121361277 @default.
• W4304128182 cites W2125731194 @default.
• W4304128182 cites W2129567809 @default.
• W4304128182 cites W2131621954 @default.
• W4304128182 cites W2132278635 @default.
• W4304128182 cites W2135711433 @default.
• W4304128182 cites W2136709687 @default.
• W4304128182 cites W2138412572 @default.
• W4304128182 cites W2148030712 @default.
• W4304128182 cites W2154214065 @default.
• W4304128182 cites W2158993411 @default.
• W4304128182 cites W2160607236 @default.
• W4304128182 cites W2172082745 @default.
• W4304128182 cites W2187576980 @default.
• W4304128182 cites W2238204934 @default.
• W4304128182 cites W2278482967 @default.
• W4304128182 cites W2298382040 @default.
• W4304128182 cites W2298437001 @default.
• W4304128182 cites W2337860672 @default.
• W4304128182 cites W2409130643 @default.
• W4304128182 cites W2414045371 @default.
• W4304128182 cites W2417513750 @default.
• W4304128182 cites W2474010152 @default.
• W4304128182 cites W2514906437 @default.
• W4304128182 cites W2583765578 @default.
• W4304128182 cites W2586636348 @default.
• W4304128182 cites W2608759269 @default.
• W4304128182 cites W2617718335 @default.
• W4304128182 cites W2727532106 @default.
• W4304128182 cites W2729704653 @default.
• W4304128182 cites W2789491425 @default.
• W4304128182 cites W2893346083 @default.
• W4304128182 cites W2905961886 @default.
• W4304128182 cites W2921659104 @default.
• W4304128182 cites W2943548923 @default.

• next