FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304165904> ?p ?o ?g. }

• W4304165904 endingPage "3182" @default.
• W4304165904 startingPage "3182" @default.
• W4304165904 abstract "Mutations in the RB1 locus leading to a loss of functional Rb protein cause intraocular tumors, which uniquely affect children worldwide. These tumors demonstrate rapid proliferation, which has recently been shown to be associated with an altered metabolic signature. We found that retinoblastoma tumors and in-vitro models lack Hexokinase 1 (HK1) and exhibit elevated fatty acid oxidation. We show that ectopic expression of RB1 induces HK1 protein in Rb null cells, and both RB1 and HK1 can mediate a metabolic switch from OXPHOS to glycolysis with increased pyruvate levels, reduced ATP production and reduced mitochondrial mass. Further, cells lacking Rb or HK1 can flexibly utilize glutamine and fatty acids to enhance oxidative phosphorylation-dependent ATP generation, as revealed by metabolic and biochemical assays. Thus, loss of Rb and HK1 in retinoblastoma reprograms tumor metabolic circuits to enhance the glucose-independent TCA (tricarboxylic acid) cycle and the intermediate NAD+/NADH ratios, with a subsequent increase in fatty-acid derived L-carnitine to enhance mitochondrial OXPHOS for ATP production instead of glycolysis dependence. We also demonstrate that modulation of the Rb-regulated transcription factor E2F2 does not result in any of these metabolic perturbations. In conclusion, we demonstrate RB1 or HK1 as critical regulators of the cellular bioenergetic profile and identify the altered tumor metabolism as a potential therapeutic target for cancers lacking functional Rb protein." @default.
• W4304165904 created "2022-10-11" @default.
• W4304165904 creator A5002653957 @default.
• W4304165904 creator A5004107977 @default.
• W4304165904 creator A5041789571 @default.
• W4304165904 creator A5065724319 @default.
• W4304165904 creator A5077227126 @default.
• W4304165904 creator A5081612313 @default.
• W4304165904 creator A5086207662 @default.
• W4304165904 creator A5087862400 @default.
• W4304165904 date "2022-10-11" @default.
• W4304165904 modified "2023-09-30" @default.
• W4304165904 title "Lack of Retinoblastoma Protein Shifts Tumor Metabolism from Glycolysis to OXPHOS and Allows the Use of Alternate Fuels" @default.
• W4304165904 cites W1555812953 @default.
• W4304165904 cites W1873761649 @default.
• W4304165904 cites W1992585187 @default.
• W4304165904 cites W2003605385 @default.
• W4304165904 cites W2026330931 @default.
• W4304165904 cites W2026555011 @default.
• W4304165904 cites W2037338364 @default.
• W4304165904 cites W2060592426 @default.
• W4304165904 cites W2074511633 @default.
• W4304165904 cites W2078990441 @default.
• W4304165904 cites W2099742439 @default.
• W4304165904 cites W2113613548 @default.
• W4304165904 cites W2116516144 @default.
• W4304165904 cites W2150578400 @default.
• W4304165904 cites W2153597782 @default.
• W4304165904 cites W2176297535 @default.
• W4304165904 cites W2181190530 @default.
• W4304165904 cites W2298460251 @default.
• W4304165904 cites W2480725775 @default.
• W4304165904 cites W2514862430 @default.
• W4304165904 cites W2697143151 @default.
• W4304165904 cites W2765258947 @default.
• W4304165904 cites W2773927148 @default.
• W4304165904 cites W2805089858 @default.
• W4304165904 cites W2810661705 @default.
• W4304165904 cites W2900963388 @default.
• W4304165904 cites W2901641202 @default.
• W4304165904 cites W2992324722 @default.
• W4304165904 cites W3009367721 @default.
• W4304165904 cites W3013544658 @default.
• W4304165904 cites W3101374665 @default.
• W4304165904 cites W3107947066 @default.
• W4304165904 cites W3147186692 @default.
• W4304165904 cites W3154308842 @default.
• W4304165904 cites W4280504208 @default.
• W4304165904 doi "https://doi.org/10.3390/cells11203182" @default.
• W4304165904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36291051" @default.
• W4304165904 hasPublicationYear "2022" @default.
• W4304165904 type Work @default.
• W4304165904 citedByCount "3" @default.
• W4304165904 countsByYear W43041659042022 @default.
• W4304165904 countsByYear W43041659042023 @default.
• W4304165904 crossrefType "journal-article" @default.
• W4304165904 hasAuthorship W4304165904A5002653957 @default.
• W4304165904 hasAuthorship W4304165904A5004107977 @default.
• W4304165904 hasAuthorship W4304165904A5041789571 @default.
• W4304165904 hasAuthorship W4304165904A5065724319 @default.
• W4304165904 hasAuthorship W4304165904A5077227126 @default.
• W4304165904 hasAuthorship W4304165904A5081612313 @default.
• W4304165904 hasAuthorship W4304165904A5086207662 @default.
• W4304165904 hasAuthorship W4304165904A5087862400 @default.
• W4304165904 hasBestOaLocation W43041659041 @default.
• W4304165904 hasConcept C100206155 @default.
• W4304165904 hasConcept C104317684 @default.
• W4304165904 hasConcept C109156525 @default.
• W4304165904 hasConcept C165135838 @default.
• W4304165904 hasConcept C20251656 @default.
• W4304165904 hasConcept C2776577112 @default.
• W4304165904 hasConcept C2776941171 @default.
• W4304165904 hasConcept C2778435403 @default.
• W4304165904 hasConcept C2779349466 @default.
• W4304165904 hasConcept C2779826832 @default.
• W4304165904 hasConcept C28859421 @default.
• W4304165904 hasConcept C515207424 @default.
• W4304165904 hasConcept C543025807 @default.
• W4304165904 hasConcept C55493867 @default.
• W4304165904 hasConcept C55885012 @default.
• W4304165904 hasConcept C57600042 @default.
• W4304165904 hasConcept C62231903 @default.
• W4304165904 hasConcept C82714985 @default.
• W4304165904 hasConcept C86803240 @default.
• W4304165904 hasConceptScore W4304165904C100206155 @default.
• W4304165904 hasConceptScore W4304165904C104317684 @default.
• W4304165904 hasConceptScore W4304165904C109156525 @default.
• W4304165904 hasConceptScore W4304165904C165135838 @default.
• W4304165904 hasConceptScore W4304165904C20251656 @default.
• W4304165904 hasConceptScore W4304165904C2776577112 @default.
• W4304165904 hasConceptScore W4304165904C2776941171 @default.
• W4304165904 hasConceptScore W4304165904C2778435403 @default.
• W4304165904 hasConceptScore W4304165904C2779349466 @default.
• W4304165904 hasConceptScore W4304165904C2779826832 @default.
• W4304165904 hasConceptScore W4304165904C28859421 @default.
• W4304165904 hasConceptScore W4304165904C515207424 @default.
• W4304165904 hasConceptScore W4304165904C543025807 @default.
• W4304165904 hasConceptScore W4304165904C55493867 @default.

• next