FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304172350> ?p ?o ?g. }

• W4304172350 endingPage "180" @default.
• W4304172350 startingPage "168" @default.
• W4304172350 abstract "Efficiency of neural stem cells (NSCs) therapy for brain injury is restricted by astrogliosis around the damaged region, in which JAK2/STAT3 signaling plays a key role. The SOCS3 that can directly inhibit JAK/STAT3 pathway. Here, we investigated the effects of a fusion peptide that combined kinase inhibitory region (KIR) of SOCS3 and virus trans-activator of transcription (TAT) on biological behavior of cultured NSCs under inflammatory conditions.NSCs were isolated from embryonic brain of SD rats, TAT-KIR was synthesized, and penetration rate was evaluated by flow cytometry (FACS). CCK8, immunostaining, and FACS were used to detected of TAT-KIR on the proliferation of NSCs. The expressions of GFAP and β tubulin III positive cells induced by IL6 with/without TAT-KIR were examined by immunostaining and Western blotting to observe the NSCs differentiation, and the effect of TAT-KIR on signaling cross talk was observed by Western blotting.Penetration rate of TAT-KIR into primary cultured NSCs was up to 94%. TAT-KIR did not affect the growth and viability of NSCs. It significantly reduced the NSCs proliferation that enhanced by IL-6 stimulation via blocking the cell cycle progression from the G0/G1 to S phase. In addition, TAT-KIR attenuated astrocytic differentiation and kept high level of neuronal differentiation derived from IL-6-induced NSCs. The fate of NSCs differentiation under inflammatory conditions was affected by TAT-KIR, which was associated with synchronous inhibition of STAT3 and AKT, while promoting JNK expression.TAT-KIR mimetic of SOCS3 could be a promising approach for brain repair via regulating the biological behaviors of exogenous NSCs." @default.
• W4304172350 created "2022-10-11" @default.
• W4304172350 creator A5010260063 @default.
• W4304172350 creator A5032092961 @default.
• W4304172350 creator A5035288269 @default.
• W4304172350 creator A5040571329 @default.
• W4304172350 creator A5047616263 @default.
• W4304172350 creator A5055514493 @default.
• W4304172350 creator A5061856481 @default.
• W4304172350 creator A5067408527 @default.
• W4304172350 creator A5073488968 @default.
• W4304172350 date "2022-10-10" @default.
• W4304172350 modified "2023-10-17" @default.
• W4304172350 title "Kinase inhibit region of <scp>SOCS3</scp> attenuates <scp>IL6</scp> ‐induced proliferation and astrocytic differentiation of neural stem cells via cross talk between signaling pathways" @default.
• W4304172350 cites W1481125586 @default.
• W4304172350 cites W1964700442 @default.
• W4304172350 cites W1965995518 @default.
• W4304172350 cites W1967551645 @default.
• W4304172350 cites W1977370355 @default.
• W4304172350 cites W1982204079 @default.
• W4304172350 cites W1994042895 @default.
• W4304172350 cites W1999218213 @default.
• W4304172350 cites W2002902649 @default.
• W4304172350 cites W2012253237 @default.
• W4304172350 cites W2013271691 @default.
• W4304172350 cites W2026399462 @default.
• W4304172350 cites W2035134361 @default.
• W4304172350 cites W2035256045 @default.
• W4304172350 cites W2040551905 @default.
• W4304172350 cites W2043162503 @default.
• W4304172350 cites W2047585900 @default.
• W4304172350 cites W2053507550 @default.
• W4304172350 cites W2056134000 @default.
• W4304172350 cites W2062375033 @default.
• W4304172350 cites W2063721381 @default.
• W4304172350 cites W2066647113 @default.
• W4304172350 cites W2088848655 @default.
• W4304172350 cites W2091898207 @default.
• W4304172350 cites W2099724117 @default.
• W4304172350 cites W2101052778 @default.
• W4304172350 cites W2101363175 @default.
• W4304172350 cites W2102092354 @default.
• W4304172350 cites W2107495112 @default.
• W4304172350 cites W2156555850 @default.
• W4304172350 cites W2164715609 @default.
• W4304172350 cites W2193215294 @default.
• W4304172350 cites W2290953607 @default.
• W4304172350 cites W2311064993 @default.
• W4304172350 cites W2346199005 @default.
• W4304172350 cites W2516840018 @default.
• W4304172350 cites W2554257031 @default.
• W4304172350 cites W2566234254 @default.
• W4304172350 cites W2585375848 @default.
• W4304172350 cites W2736438823 @default.
• W4304172350 cites W2747715410 @default.
• W4304172350 cites W2788157186 @default.
• W4304172350 cites W2788489832 @default.
• W4304172350 cites W2801645180 @default.
• W4304172350 cites W2892697969 @default.
• W4304172350 cites W2897586056 @default.
• W4304172350 cites W3018809241 @default.
• W4304172350 cites W3026323285 @default.
• W4304172350 cites W3027113564 @default.
• W4304172350 cites W4304172350 @default.
• W4304172350 cites W936533906 @default.
• W4304172350 doi "https://doi.org/10.1111/cns.13992" @default.
• W4304172350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36217678" @default.
• W4304172350 hasPublicationYear "2022" @default.
• W4304172350 type Work @default.
• W4304172350 citedByCount "3" @default.
• W4304172350 countsByYear W43041723502022 @default.
• W4304172350 countsByYear W43041723502023 @default.
• W4304172350 crossrefType "journal-article" @default.
• W4304172350 hasAuthorship W4304172350A5010260063 @default.
• W4304172350 hasAuthorship W4304172350A5032092961 @default.
• W4304172350 hasAuthorship W4304172350A5035288269 @default.
• W4304172350 hasAuthorship W4304172350A5040571329 @default.
• W4304172350 hasAuthorship W4304172350A5047616263 @default.
• W4304172350 hasAuthorship W4304172350A5055514493 @default.
• W4304172350 hasAuthorship W4304172350A5061856481 @default.
• W4304172350 hasAuthorship W4304172350A5067408527 @default.
• W4304172350 hasAuthorship W4304172350A5073488968 @default.
• W4304172350 hasBestOaLocation W43041723502 @default.
• W4304172350 hasConcept C126042315 @default.
• W4304172350 hasConcept C136834591 @default.
• W4304172350 hasConcept C153911025 @default.
• W4304172350 hasConcept C185592680 @default.
• W4304172350 hasConcept C2778923194 @default.
• W4304172350 hasConcept C28328180 @default.
• W4304172350 hasConcept C62478195 @default.
• W4304172350 hasConcept C75217442 @default.
• W4304172350 hasConcept C86803240 @default.
• W4304172350 hasConcept C95444343 @default.
• W4304172350 hasConceptScore W4304172350C126042315 @default.
• W4304172350 hasConceptScore W4304172350C136834591 @default.
• W4304172350 hasConceptScore W4304172350C153911025 @default.
• W4304172350 hasConceptScore W4304172350C185592680 @default.
• W4304172350 hasConceptScore W4304172350C2778923194 @default.

• next