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• W4304175380 endingPage "2007" @default.
• W4304175380 startingPage "2007" @default.
• W4304175380 abstract "Donors of nitroxyl and nitroxyl anion (HNO/NO-) are considered to be promising pharmacological treatments with a wide range of applications. Remarkable chemical properties allow nitroxyl to function as a classic antioxidant. We assume that HNO/NO- can level down the non-enzymatic glycation of biomolecules. Since erythrocyte hemoglobin (Hb) is highly susceptible to non-enzymatic glycation, we studied the effect of a nitroxyl donor, Angeli's salt, on Hb modification with methylglyoxal (MG) and organic peroxide-tert-butyl hydroperoxide (t-BOOH). Nitroxyl dose-dependently decreased the amount of protein carbonyls and advanced glycation end products (AGEs) that were formed in the case of Hb incubation with MG. Likewise, nitroxyl effectively protected Hb against oxidative modification with t-BOOH. It slowed down the destruction of heme, formation of carbonyl derivatives and inter-subunit cross-linking. The protective effect of nitroxyl on Hb in this system is primarily associated with nitrosylation of oxidized Hb and reduction of its ferryl form, which lowers the yield of free radical products. We suppose that the dual (antioxidant and antiglycation) effect of nitroxyl makes its application possible as part of an additional treatment strategy for oxidative and carbonyl stress-associated diseases." @default.
• W4304175380 created "2022-10-11" @default.
• W4304175380 creator A5006602899 @default.
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• W4304175380 creator A5065420084 @default.
• W4304175380 creator A5076997242 @default.
• W4304175380 date "2022-10-11" @default.
• W4304175380 modified "2023-09-30" @default.
• W4304175380 title "Antiglycation and Antioxidant Effect of Nitroxyl towards Hemoglobin" @default.
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• W4304175380 doi "https://doi.org/10.3390/antiox11102007" @default.
• W4304175380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36290730" @default.
• W4304175380 hasPublicationYear "2022" @default.
• W4304175380 type Work @default.

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