FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304183700> ?p ?o ?g. }

• W4304183700 abstract "Disorders of lipoprotein metabolism have been linked with an increased risk of cardiovascular diseases (CVDs) but the causal association is unclear. In this study, we investigated the causal association between disorders of lipoprotein metabolism and CVDs using two-sample Mendelian randomization (MR). The exposure was obtained from Finn genome-wide association studies (14,010 cases, 197,259 controls), and the corresponding CVDs were extracted from the largest published genome-wide association studies. A random-effects inverse-variance weighted method was used for the main analyses with a complementary analysis using the weighted median and MR-Egger approaches. Multiple sensitivity analyses were performed to assess horizontal pleiotropy. The MR analysis indicated positive associations of disorders of lipoprotein metabolism with coronary artery disease (odds ratio [OR] 1.670, 95% confidence interval [CI] 1.373-2.031; p < 0.001), aortic aneurysm (OR 1.394, 95% CI 1.199-1.619; p < 0.001), heart failure (OR 1.20, 95% CI 1.115-1.294; p < 0.001), hypertension (OR 1.011, 95% CI 1.006-1.091; p < 0.001), old myocardial infarction (OR 1.004, 95% CI 1.002-1.007; p = 0.001), and stroke (OR 1.002, 95% CI 1.001-1.003; p = 0.002). There is a suggestive causal relationship between disorders of lipoprotein metabolism and atrial fibrillation (OR 1.047, 95% CI 1.006-1.091; p = 0.026) and acute myocardial infarction (OR 1.003, 95% CI 1.001-1.005; p = 0.012). There was limited evidence of a causal association between disorders of lipoprotein metabolism and peripheral vascular disease and venous thromboembolism. Our findings indicate a significant causal association between disorders of lipoprotein metabolism and many CVDs, including coronary artery disease, aortic aneurysm, heart failure, hypertension, old myocardial infarction, and stroke. These associations may be useful for development of treatment strategies that regulate lipoprotein metabolism in patients with CVD." @default.
• W4304183700 created "2022-10-11" @default.
• W4304183700 creator A5002656825 @default.
• W4304183700 creator A5015753751 @default.
• W4304183700 creator A5017364136 @default.
• W4304183700 creator A5052493382 @default.
• W4304183700 creator A5074865975 @default.
• W4304183700 creator A5081027441 @default.
• W4304183700 date "2022-10-11" @default.
• W4304183700 modified "2023-09-24" @default.
• W4304183700 title "Causal associations between disorders of lipoprotein metabolism and ten cardiovascular diseases" @default.
• W4304183700 cites W1908289777 @default.
• W4304183700 cites W1988163135 @default.
• W4304183700 cites W1990204315 @default.
• W4304183700 cites W2018327621 @default.
• W4304183700 cites W2039988386 @default.
• W4304183700 cites W2067103740 @default.
• W4304183700 cites W2098230963 @default.
• W4304183700 cites W2104355263 @default.
• W4304183700 cites W2110052313 @default.
• W4304183700 cites W2112121119 @default.
• W4304183700 cites W2169283889 @default.
• W4304183700 cites W2490528887 @default.
• W4304183700 cites W2492485425 @default.
• W4304183700 cites W2564082722 @default.
• W4304183700 cites W2586892149 @default.
• W4304183700 cites W2775393828 @default.
• W4304183700 cites W2803072880 @default.
• W4304183700 cites W2884743521 @default.
• W4304183700 cites W2885308025 @default.
• W4304183700 cites W2942547854 @default.
• W4304183700 cites W2990674281 @default.
• W4304183700 cites W2999230481 @default.
• W4304183700 cites W3011963422 @default.
• W4304183700 cites W3121012153 @default.
• W4304183700 cites W3127059943 @default.
• W4304183700 cites W3197821535 @default.
• W4304183700 cites W3214080475 @default.
• W4304183700 cites W4200613051 @default.
• W4304183700 cites W4210703904 @default.
• W4304183700 cites W4255815262 @default.
• W4304183700 doi "https://doi.org/10.3389/fcell.2022.1023006" @default.
• W4304183700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36303606" @default.
• W4304183700 hasPublicationYear "2022" @default.
• W4304183700 type Work @default.
• W4304183700 citedByCount "0" @default.
• W4304183700 crossrefType "journal-article" @default.
• W4304183700 hasAuthorship W4304183700A5002656825 @default.
• W4304183700 hasAuthorship W4304183700A5015753751 @default.
• W4304183700 hasAuthorship W4304183700A5017364136 @default.
• W4304183700 hasAuthorship W4304183700A5052493382 @default.
• W4304183700 hasAuthorship W4304183700A5074865975 @default.
• W4304183700 hasAuthorship W4304183700A5081027441 @default.
• W4304183700 hasBestOaLocation W43041837001 @default.
• W4304183700 hasConcept C104317684 @default.
• W4304183700 hasConcept C106208931 @default.
• W4304183700 hasConcept C126322002 @default.
• W4304183700 hasConcept C127413603 @default.
• W4304183700 hasConcept C135763542 @default.
• W4304183700 hasConcept C153209595 @default.
• W4304183700 hasConcept C156957248 @default.
• W4304183700 hasConcept C164705383 @default.
• W4304183700 hasConcept C2778213512 @default.
• W4304183700 hasConcept C2779901538 @default.
• W4304183700 hasConcept C2780645631 @default.
• W4304183700 hasConcept C2993967602 @default.
• W4304183700 hasConcept C44249647 @default.
• W4304183700 hasConcept C500558357 @default.
• W4304183700 hasConcept C54355233 @default.
• W4304183700 hasConcept C71924100 @default.
• W4304183700 hasConcept C78519656 @default.
• W4304183700 hasConcept C86803240 @default.
• W4304183700 hasConceptScore W4304183700C104317684 @default.
• W4304183700 hasConceptScore W4304183700C106208931 @default.
• W4304183700 hasConceptScore W4304183700C126322002 @default.
• W4304183700 hasConceptScore W4304183700C127413603 @default.
• W4304183700 hasConceptScore W4304183700C135763542 @default.
• W4304183700 hasConceptScore W4304183700C153209595 @default.
• W4304183700 hasConceptScore W4304183700C156957248 @default.
• W4304183700 hasConceptScore W4304183700C164705383 @default.
• W4304183700 hasConceptScore W4304183700C2778213512 @default.
• W4304183700 hasConceptScore W4304183700C2779901538 @default.
• W4304183700 hasConceptScore W4304183700C2780645631 @default.
• W4304183700 hasConceptScore W4304183700C2993967602 @default.
• W4304183700 hasConceptScore W4304183700C44249647 @default.
• W4304183700 hasConceptScore W4304183700C500558357 @default.
• W4304183700 hasConceptScore W4304183700C54355233 @default.
• W4304183700 hasConceptScore W4304183700C71924100 @default.
• W4304183700 hasConceptScore W4304183700C78519656 @default.
• W4304183700 hasConceptScore W4304183700C86803240 @default.
• W4304183700 hasFunder F4320321001 @default.
• W4304183700 hasLocation W43041837001 @default.
• W4304183700 hasLocation W43041837002 @default.
• W4304183700 hasLocation W43041837003 @default.
• W4304183700 hasLocation W43041837004 @default.
• W4304183700 hasOpenAccess W4304183700 @default.
• W4304183700 hasPrimaryLocation W43041837001 @default.
• W4304183700 hasRelatedWork W1974032428 @default.
• W4304183700 hasRelatedWork W1994858555 @default.
• W4304183700 hasRelatedWork W2133630700 @default.

• next