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- W4304183732 abstract "Extracellular vesicles (EVs) have potential in disease treatment since they can be loaded with therapeutic molecules and engineered for retention by specific tissues. However, questions remain on optimal dosing, administration, and pharmacokinetics. Previous studies have addressed biodistribution and pharmacokinetics in rodents, but little evidence is available for larger animals. Here, we investigated the pharmacokinetics and biodistribution of Expi293F-derived EVs labelled with a highly sensitive nanoluciferase reporter (palmGRET) in a non-human primate model (Macaca nemestrina), comparing intravenous (IV) and intranasal (IN) administration over a 125-fold dose range. We report that EVs administered IV had longer circulation times in plasma than previously reported in mice and were detectable in cerebrospinal fluid (CSF) after 30-60 minutes. EV association with PBMCs, especially B-cells, was observed as early as one minute post-administration. EVs were detected in liver and spleen within one hour of IV administration. However, IN delivery was minimal, suggesting that pretreatment approaches may be needed in large animals. Furthermore, EV circulation times strongly decreased after repeated IV administration, possibly due to immune responses and with clear implications for xenogeneic EV-based therapeutics. We hope that our findings from this baseline study in macaques will help to inform future research and therapeutic development of EVs." @default.
- W4304183732 created "2022-10-11" @default.
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- W4304183732 date "2022-10-01" @default.
- W4304183732 modified "2023-10-17" @default.
- W4304183732 title "Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to <i>Macaca nemestrina</i>" @default.
- W4304183732 cites W1496703419 @default.
- W4304183732 cites W1612359316 @default.
- W4304183732 cites W1917937260 @default.
- W4304183732 cites W1950118853 @default.
- W4304183732 cites W1966606134 @default.
- W4304183732 cites W1967708672 @default.
- W4304183732 cites W1984313604 @default.
- W4304183732 cites W1986648571 @default.
- W4304183732 cites W2001146592 @default.
- W4304183732 cites W2040635479 @default.
- W4304183732 cites W2066234893 @default.
- W4304183732 cites W2071625709 @default.
- W4304183732 cites W2072153678 @default.
- W4304183732 cites W2086856055 @default.
- W4304183732 cites W2097980094 @default.
- W4304183732 cites W2124304994 @default.
- W4304183732 cites W2134596993 @default.
- W4304183732 cites W2146668660 @default.
- W4304183732 cites W2156946852 @default.
- W4304183732 cites W2207291742 @default.
- W4304183732 cites W2223591983 @default.
- W4304183732 cites W2262018451 @default.
- W4304183732 cites W2347148183 @default.
- W4304183732 cites W2466551530 @default.
- W4304183732 cites W2594599876 @default.
- W4304183732 cites W2599584702 @default.
- W4304183732 cites W2603213989 @default.
- W4304183732 cites W2608697804 @default.
- W4304183732 cites W2621533948 @default.
- W4304183732 cites W2624616322 @default.
- W4304183732 cites W2735330142 @default.
- W4304183732 cites W2754835295 @default.
- W4304183732 cites W2757807906 @default.
- W4304183732 cites W2763075550 @default.
- W4304183732 cites W2793224592 @default.
- W4304183732 cites W2799422921 @default.
- W4304183732 cites W2808067587 @default.
- W4304183732 cites W2808148330 @default.
- W4304183732 cites W2808667519 @default.
- W4304183732 cites W2892516612 @default.
- W4304183732 cites W2900756811 @default.
- W4304183732 cites W2902448517 @default.
- W4304183732 cites W2904976916 @default.
- W4304183732 cites W2922192203 @default.
- W4304183732 cites W2923606319 @default.
- W4304183732 cites W2948893547 @default.
- W4304183732 cites W2950757810 @default.
- W4304183732 cites W2950891082 @default.
- W4304183732 cites W2951105374 @default.
- W4304183732 cites W2960989010 @default.
- W4304183732 cites W2964806815 @default.
- W4304183732 cites W2968489197 @default.
- W4304183732 cites W3005437667 @default.
- W4304183732 cites W3011668109 @default.
- W4304183732 cites W3041242267 @default.
- W4304183732 cites W3049438671 @default.
- W4304183732 cites W3081483355 @default.
- W4304183732 cites W3081869224 @default.
- W4304183732 cites W3107886088 @default.
- W4304183732 cites W3118265258 @default.
- W4304183732 cites W3120928762 @default.
- W4304183732 cites W3123997015 @default.
- W4304183732 cites W3131515933 @default.
- W4304183732 cites W3138127439 @default.
- W4304183732 cites W3157534925 @default.
- W4304183732 cites W3160542292 @default.
- W4304183732 cites W3160930536 @default.
- W4304183732 cites W3173559534 @default.
- W4304183732 cites W3175106066 @default.
- W4304183732 cites W3182849201 @default.