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- W4304183973 abstract "Objective Macrolide resistance in Mycoplasma genitalium ( M. genitalium) is increasing as a result of the widespread use of azithromycin in the treatment of sexually transmitted infections (STIs). To date, there are few published studies on macrolide resistance patterns in South African pregnant women. This study now contributes to the growing body of knowledge. Methods This study included 385 pregnant women living with HIV. Vaginal swabs were collected from consenting pregnant women and used for the detection of M. genitalium using the TaqMan assay . Macrolide resistance-associated mutations in the 23S rRNA gene were determined for all samples that tested positive for M. genitalium using the Allplex TM MG & AziR assay (Seegene) which allows for the simultaneous detection and identification of M. genitalium and six mutations ( A2058C, A2058G, A2058T, A2059C, A2059G and A2059T) responsible for azithromycin resistance. The correlation between the TaqMan assay and Allplex TM MG & AziR assay (Seegene) for the detection of M. genitalium was also performed in a subset of 121 samples. Results Of the 385 samples tested in this study, 14 samples were positive for M. genitalium estimating a prevalence of 3.6%. The same 14 samples also tested positive on the Allplex TM assay indicating a good correlation between the TaqMan Assay and the Allplex TM . Of the 14 positive samples, one sample carried a mutation at position A2059G denoting macrolide resistance in this pathogen. Mutations in the other regions of the 23S rRNA were not detected. All assay controls used in the mutation scanning produced the desired results showing the validity of the assay. Conclusion In this study, macrolide resistance in M. genitalium was detected. Despite the low prevalence of resistance determinants ongoing antimicrobial resistance surveillance is vital considering that azithromycin is used in the syndromic management for the treatment of vaginal discharge syndrome." @default.
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- W4304183973 date "2022-10-11" @default.
- W4304183973 modified "2023-09-27" @default.
- W4304183973 title "Low prevalence of macrolide resistance in <i>Mycoplasma genitalium</i> infections in a cohort of pregnant women living with human immunodeficiency virus" @default.
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- W4304183973 doi "https://doi.org/10.1177/09564624221129412" @default.
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