Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304184595> ?p ?o ?g. }
- W4304184595 endingPage "16" @default.
- W4304184595 startingPage "1" @default.
- W4304184595 abstract "Oncogene addiction in non-small-cell lung cancer (NSCLC) has profound diagnostic and therapeutic implications. ALK, ROS1 and NTRK rearrangements are found in about 2–7%, 1–2% and 0.2% of unselected NSCLC samples, respectively; however, their frequency is markedly higher in younger and never-smoker patients with adenocarcinoma histology. Moreover, ALK, ROS1 and NTRK rearrangements are often mutually exclusive with other known driver alterations in NSCLC. Due to such a low frequency, diagnostic screening with accurate and inexpensive techniques such as immunohistochemistry is useful to identify positive cases; however, confirmation with fluorescent in situ hybridization or next-generation sequencing is often required due to higher specificity. In ALK-rearranged NSCLC, sequential treatment with second-generation and third-generation tyrosine kinase inhibitors leads to long-lasting disease control with most patients surviving beyond 5 years with metastatic disease. In ROS1-rearranged NSCLC, first-line treatment with crizotinib or entrectinib and subsequent treatment with lorlatinib at disease progression leads to similar results in patients with metastatic disease. NTRK1–3 fusions are extremely rare in unselected NSCLC. However, treatment with TRK inhibitors yields high response rates and durable disease control in most patients; diagnostic screening through multigene DNA/ RNA-based next-generation sequencing testing is therefore crucial to identify positive cases." @default.
- W4304184595 created "2022-10-11" @default.
- W4304184595 creator A5002364166 @default.
- W4304184595 creator A5030450694 @default.
- W4304184595 creator A5034761732 @default.
- W4304184595 creator A5060183078 @default.
- W4304184595 creator A5078418283 @default.
- W4304184595 date "2022-10-12" @default.
- W4304184595 modified "2023-09-30" @default.
- W4304184595 title "Non-small-cell lung cancer: how to manage ALK-, ROS1- and NTRK-rearranged disease" @default.
- W4304184595 cites W1766332810 @default.
- W4304184595 cites W1974903221 @default.
- W4304184595 cites W1975784282 @default.
- W4304184595 cites W1976059757 @default.
- W4304184595 cites W1990626198 @default.
- W4304184595 cites W1994384682 @default.
- W4304184595 cites W1997505729 @default.
- W4304184595 cites W1997920733 @default.
- W4304184595 cites W2000079550 @default.
- W4304184595 cites W2002127983 @default.
- W4304184595 cites W2010619956 @default.
- W4304184595 cites W2016343445 @default.
- W4304184595 cites W2020244870 @default.
- W4304184595 cites W2023757019 @default.
- W4304184595 cites W2031494655 @default.
- W4304184595 cites W2050249255 @default.
- W4304184595 cites W2052546787 @default.
- W4304184595 cites W2052574738 @default.
- W4304184595 cites W2064378491 @default.
- W4304184595 cites W2073611916 @default.
- W4304184595 cites W2087390525 @default.
- W4304184595 cites W2090226388 @default.
- W4304184595 cites W2091309613 @default.
- W4304184595 cites W2099530756 @default.
- W4304184595 cites W2103225497 @default.
- W4304184595 cites W2104830962 @default.
- W4304184595 cites W2110024096 @default.
- W4304184595 cites W2116478428 @default.
- W4304184595 cites W2123394258 @default.
- W4304184595 cites W2127129900 @default.
- W4304184595 cites W2130488043 @default.
- W4304184595 cites W2134640949 @default.
- W4304184595 cites W2146448515 @default.
- W4304184595 cites W2147038864 @default.
- W4304184595 cites W2148332636 @default.
- W4304184595 cites W2153345506 @default.
- W4304184595 cites W2158638287 @default.
- W4304184595 cites W2168635759 @default.
- W4304184595 cites W2168691181 @default.
- W4304184595 cites W2181333015 @default.
- W4304184595 cites W2205667543 @default.
- W4304184595 cites W2292803562 @default.
- W4304184595 cites W2304533799 @default.
- W4304184595 cites W2310252196 @default.
- W4304184595 cites W2471664064 @default.
- W4304184595 cites W2482427906 @default.
- W4304184595 cites W2537733368 @default.
- W4304184595 cites W2551769647 @default.
- W4304184595 cites W2564366019 @default.
- W4304184595 cites W2576204976 @default.
- W4304184595 cites W2581996620 @default.
- W4304184595 cites W2586629973 @default.
- W4304184595 cites W2586704604 @default.
- W4304184595 cites W2610816290 @default.
- W4304184595 cites W2613260339 @default.
- W4304184595 cites W2614720739 @default.
- W4304184595 cites W2620626563 @default.
- W4304184595 cites W2623725180 @default.
- W4304184595 cites W2624310346 @default.
- W4304184595 cites W2738437255 @default.
- W4304184595 cites W2745391639 @default.
- W4304184595 cites W2748599797 @default.
- W4304184595 cites W2767917908 @default.
- W4304184595 cites W2784414491 @default.
- W4304184595 cites W2784538417 @default.
- W4304184595 cites W2785110924 @default.
- W4304184595 cites W2790254562 @default.
- W4304184595 cites W2791185794 @default.
- W4304184595 cites W2794472180 @default.
- W4304184595 cites W2794491531 @default.
- W4304184595 cites W2796923356 @default.
- W4304184595 cites W2797685139 @default.
- W4304184595 cites W2800286167 @default.
- W4304184595 cites W2810788886 @default.
- W4304184595 cites W2846588575 @default.
- W4304184595 cites W2883016549 @default.
- W4304184595 cites W2885875860 @default.
- W4304184595 cites W2890523839 @default.
- W4304184595 cites W2894476389 @default.
- W4304184595 cites W2896424462 @default.
- W4304184595 cites W2897321755 @default.
- W4304184595 cites W2898633288 @default.
- W4304184595 cites W2899366033 @default.
- W4304184595 cites W2899668190 @default.
- W4304184595 cites W2923683745 @default.
- W4304184595 cites W2938245541 @default.
- W4304184595 cites W2938369148 @default.
- W4304184595 cites W2939690516 @default.