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• W4304185364 abstract "Abstract The human cerebral cortex is vastly expanded relative to nonhuman primates and rodents, leading to a functional orderly topography of brain networks. Here, we show that functional topography may be associated with gene expression heterogeneity. The neocortex exhibits greater heterogeneity in gene expression, with a lower expression of housekeeping genes, a longer mean path length, fewer clusters, and a lower degree of ordering in networks than archicortical and subcortical areas in human, rhesus macaque, and mouse brains. In particular, the cerebellar cortex displays greater heterogeneity in gene expression than cerebellar deep nuclei in the human brain, but not in the mouse brain, corresponding to the emergence of novel functions in the human cerebellar cortex. Moreover, the cortical areas with greater heterogeneity, primarily located in the multimodal association cortex, tend to express genes with higher evolutionary rates and exhibit a higher degree of functional connectivity measured by resting-state fMRI, implying that such a spatial distribution of gene expression may be shaped by evolution and is favourable for the specialization of higher cognitive functions. Together, the cross-species imaging and genetic findings may provide convergent evidence to support the association between the orderly topography of brain function networks and gene expression." @default.
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• W4304185364 date "2022-10-11" @default.
• W4304185364 modified "2023-10-18" @default.
• W4304185364 title "Functional orderly topography of brain networks associated with gene expression heterogeneity" @default.
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• W4304185364 doi "https://doi.org/10.1038/s42003-022-04039-8" @default.
• W4304185364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36220938" @default.
• W4304185364 hasPublicationYear "2022" @default.
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