Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304190027> ?p ?o ?g. }
- W4304190027 abstract "Precise control of protein degradation is critical for life, yet how natural genetic variation affects this essential process is largely unknown. Here, we developed a statistically powerful mapping approach to characterize how genetic variation affects protein degradation by the ubiquitin-proteasome system (UPS). Using the yeast Saccharomyces cerevisiae, we systematically mapped genetic influences on the N-end rule, a UPS pathway in which protein N-terminal amino acids function as degradation-promoting signals. Across all 20 possible N-terminal amino acids, we identified 149 genomic loci that influence UPS activity, many of which had pathway- or substrate-specific effects. Fine-mapping of four loci identified multiple causal variants in each of four ubiquitin system genes whose products process (NTA1), recognize (UBR1 and DOA10), and ubiquitinate (UBC6) cellular proteins. A cis-acting promoter variant that modulates UPS activity by altering UBR1 expression alters the abundance of 36 proteins without affecting levels of the corresponding mRNA transcripts. Our results reveal a complex genetic basis of variation in UPS activity." @default.
- W4304190027 created "2022-10-11" @default.
- W4304190027 creator A5004960989 @default.
- W4304190027 creator A5049048594 @default.
- W4304190027 creator A5081858397 @default.
- W4304190027 date "2022-10-11" @default.
- W4304190027 modified "2023-09-26" @default.
- W4304190027 title "Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation" @default.
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