Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304196249> ?p ?o ?g. }
- W4304196249 endingPage "111485" @default.
- W4304196249 startingPage "111485" @default.
- W4304196249 abstract "We report an approach to identify tumor-specific CD4+ T cell neo-epitopes of both mouse and human cancer cells by analysis of major histocompatibility complex (MHC) class II-eluted natural peptides. MHC class II-presented peptide sequences are identified by introducing the MHC class II transactivator (CIITA) in tumor cells that were originally MHC class II negative. CIITA expression facilitates cell-surface expression of MHC class II molecules and the appropriate peptide-loading machinery. Peptide elution of purified MHC class II molecules and subsequent mass spectrometry reveals oncoviral- and neo-epitopes as well as shared epitopes. Immunological relevance of these epitopes is shown by natural presentation by dendritic cells and immunogenicity. Synthetic peptide vaccination induced functional CD4+ T cell responses, which helped tumor control in vivo. Thus, this CIITA transfection approach aids to identify relevant T helper epitopes presented by any MHC class II allele that would be otherwise very difficult to predict and reveals important targets for cancer immunotherapy." @default.
- W4304196249 created "2022-10-11" @default.
- W4304196249 creator A5007356312 @default.
- W4304196249 creator A5018521491 @default.
- W4304196249 creator A5023498056 @default.
- W4304196249 creator A5032939795 @default.
- W4304196249 creator A5035490415 @default.
- W4304196249 creator A5035823763 @default.
- W4304196249 creator A5037073179 @default.
- W4304196249 creator A5047128619 @default.
- W4304196249 creator A5047838883 @default.
- W4304196249 creator A5056644878 @default.
- W4304196249 creator A5057464279 @default.
- W4304196249 creator A5061083695 @default.
- W4304196249 date "2022-10-01" @default.
- W4304196249 modified "2023-10-01" @default.
- W4304196249 title "Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA" @default.
- W4304196249 cites W1537314431 @default.
- W4304196249 cites W1629735417 @default.
- W4304196249 cites W1741548448 @default.
- W4304196249 cites W1884857780 @default.
- W4304196249 cites W1963584953 @default.
- W4304196249 cites W2006629564 @default.
- W4304196249 cites W2006759360 @default.
- W4304196249 cites W2008667095 @default.
- W4304196249 cites W2012169024 @default.
- W4304196249 cites W2015848550 @default.
- W4304196249 cites W2059385530 @default.
- W4304196249 cites W2063366670 @default.
- W4304196249 cites W2072541256 @default.
- W4304196249 cites W2079696222 @default.
- W4304196249 cites W2085831528 @default.
- W4304196249 cites W2086469768 @default.
- W4304196249 cites W2095352046 @default.
- W4304196249 cites W2103452148 @default.
- W4304196249 cites W2108706633 @default.
- W4304196249 cites W2112643590 @default.
- W4304196249 cites W2138733343 @default.
- W4304196249 cites W2142844745 @default.
- W4304196249 cites W2152892875 @default.
- W4304196249 cites W2162332541 @default.
- W4304196249 cites W2169087417 @default.
- W4304196249 cites W2198641185 @default.
- W4304196249 cites W2514929667 @default.
- W4304196249 cites W2559918261 @default.
- W4304196249 cites W2586712356 @default.
- W4304196249 cites W2724264513 @default.
- W4304196249 cites W2728365508 @default.
- W4304196249 cites W2767624281 @default.
- W4304196249 cites W2779582662 @default.
- W4304196249 cites W2792688048 @default.
- W4304196249 cites W2884754721 @default.
- W4304196249 cites W2885650843 @default.
- W4304196249 cites W2951821937 @default.
- W4304196249 cites W2981190097 @default.
- W4304196249 cites W2982049472 @default.
- W4304196249 cites W3021254998 @default.
- W4304196249 cites W3023944188 @default.
- W4304196249 cites W3088579978 @default.
- W4304196249 cites W4226107717 @default.
- W4304196249 cites W4234797714 @default.
- W4304196249 doi "https://doi.org/10.1016/j.celrep.2022.111485" @default.
- W4304196249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36223747" @default.
- W4304196249 hasPublicationYear "2022" @default.
- W4304196249 type Work @default.
- W4304196249 citedByCount "2" @default.
- W4304196249 countsByYear W43041962492023 @default.
- W4304196249 crossrefType "journal-article" @default.
- W4304196249 hasAuthorship W4304196249A5007356312 @default.
- W4304196249 hasAuthorship W4304196249A5018521491 @default.
- W4304196249 hasAuthorship W4304196249A5023498056 @default.
- W4304196249 hasAuthorship W4304196249A5032939795 @default.
- W4304196249 hasAuthorship W4304196249A5035490415 @default.
- W4304196249 hasAuthorship W4304196249A5035823763 @default.
- W4304196249 hasAuthorship W4304196249A5037073179 @default.
- W4304196249 hasAuthorship W4304196249A5047128619 @default.
- W4304196249 hasAuthorship W4304196249A5047838883 @default.
- W4304196249 hasAuthorship W4304196249A5056644878 @default.
- W4304196249 hasAuthorship W4304196249A5057464279 @default.
- W4304196249 hasAuthorship W4304196249A5061083695 @default.
- W4304196249 hasBestOaLocation W43041962491 @default.
- W4304196249 hasConcept C108249834 @default.
- W4304196249 hasConcept C119997001 @default.
- W4304196249 hasConcept C147483822 @default.
- W4304196249 hasConcept C170627219 @default.
- W4304196249 hasConcept C195616568 @default.
- W4304196249 hasConcept C203014093 @default.
- W4304196249 hasConcept C207936829 @default.
- W4304196249 hasConcept C2775890610 @default.
- W4304196249 hasConcept C2776090121 @default.
- W4304196249 hasConcept C2778814158 @default.
- W4304196249 hasConcept C83464605 @default.
- W4304196249 hasConcept C86803240 @default.
- W4304196249 hasConcept C8891405 @default.
- W4304196249 hasConceptScore W4304196249C108249834 @default.
- W4304196249 hasConceptScore W4304196249C119997001 @default.
- W4304196249 hasConceptScore W4304196249C147483822 @default.
- W4304196249 hasConceptScore W4304196249C170627219 @default.