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- W4304203428 abstract "Bioengineered transplantable heart-lung scaffolds could be potentially lifesaving in a large number of congenital and acquired cardiothoracic disorders including terminal heart-lung disease.We decellularized heart-lung organ-blocks from rats (n = 10) by coronary and tracheal perfusion with ionic detergents in a modified Langendorff circuit.In the present project, we were able to achieve complete decellularization of the heart-lung organ-block. Decellularized heart-lung organ-blocks lacked intracellular components but maintained structure of the cellular walls with collagen and elastic fibers.We present a novel model of combined perfusion and decellularization of heart-lung organ-blocks. This model is the first step on the pathway to creating bioengineered transplantable heart-lung scaffolds. We believe that further development of this technology could provide a life-saving conduit, significantly reducing the risks of heart-lung failure surgery and improving postoperative quality of life." @default.
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- W4304203428 date "2022-10-18" @default.
- W4304203428 modified "2023-10-13" @default.
- W4304203428 title "Development and evaluation of a novel combined perfusion decellularization heart‐lung model for tissue engineering of bioartificial heart‐lung scaffolds" @default.
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- W4304203428 doi "https://doi.org/10.1111/aor.14419" @default.
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