FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304208539> ?p ?o ?g. }

• W4304208539 endingPage "179" @default.
• W4304208539 startingPage "173" @default.
• W4304208539 abstract "Blood donations are routinely screened for HIV to prevent an infectious unit from being released to the blood supply. Despite improvements to blood screening assays, donations from infected donors remain undetectable during the window period (WP), when the virus has not yet replicated above the lower limit of detection (LOD) of a screening assay. To aid in the quantitative risk assessments of WP donations, a dose-response model describing the probability of transfusion-transmission of HIV over a range of viral RNA copies was developed.An exponential model was chosen based on data fit and parsimony. A data set from a HIV challenge study using a nonhuman primate model and another data set from reported human blood transfusions associated with HIV infected donors were separately fit to the model to generate parameter estimates. A Bayesian framework using No-U-Turn Sampling (NUTS) and Monte Carlo simulations was performed to generate posterior distributions quantifying uncertainty in parameter estimation and model predictions.The parameters of the exponential model for both nonhuman primate and human data were estimated with a mean (95% credible intervals) of 2.70 × 10 -2 (7.74 × 10 -3 , 6.06 × 10 -2 ) and 7.56 × 10 -4 (3.68 × 10 -4 , 1.31 × 10 -3 ), respectively. The predicted ID 50 for the animal and human models was 26 (12, 90) and 918 (529, 1886) RNA copies transfused, respectively.This dose-response model can be used in a quantitative framework to estimate the probability of transfusion-transmission of HIV through WP donations. These models can be especially informative when assessing risk from blood components with low viral load." @default.
• W4304208539 created "2022-10-11" @default.
• W4304208539 creator A5004248801 @default.
• W4304208539 creator A5006332107 @default.
• W4304208539 creator A5008758398 @default.
• W4304208539 creator A5035089475 @default.
• W4304208539 creator A5049614741 @default.
• W4304208539 creator A5054715645 @default.
• W4304208539 creator A5087332112 @default.
• W4304208539 date "2023-02-01" @default.
• W4304208539 modified "2023-10-18" @default.
• W4304208539 title "Modeling the Risk of HIV Transfusion Transmission" @default.
• W4304208539 cites W1528397860 @default.
• W4304208539 cites W1571885045 @default.
• W4304208539 cites W1859074717 @default.
• W4304208539 cites W1877071241 @default.
• W4304208539 cites W1905270355 @default.
• W4304208539 cites W1934727085 @default.
• W4304208539 cites W1939131042 @default.
• W4304208539 cites W1977900740 @default.
• W4304208539 cites W2015588479 @default.
• W4304208539 cites W2033693965 @default.
• W4304208539 cites W2057525179 @default.
• W4304208539 cites W2063950143 @default.
• W4304208539 cites W2068318107 @default.
• W4304208539 cites W2096641399 @default.
• W4304208539 cites W2098265861 @default.
• W4304208539 cites W2130902307 @default.
• W4304208539 cites W2131043343 @default.
• W4304208539 cites W2138994534 @default.
• W4304208539 cites W2144150348 @default.
• W4304208539 cites W2144671131 @default.
• W4304208539 cites W2145893755 @default.
• W4304208539 cites W2148994127 @default.
• W4304208539 cites W2149824634 @default.
• W4304208539 cites W2152176581 @default.
• W4304208539 cites W2180645870 @default.
• W4304208539 cites W2292538846 @default.
• W4304208539 cites W2804500674 @default.
• W4304208539 cites W2892927211 @default.
• W4304208539 cites W2915128108 @default.
• W4304208539 cites W2915594681 @default.
• W4304208539 cites W2947914116 @default.
• W4304208539 cites W3006800229 @default.
• W4304208539 cites W3045441206 @default.
• W4304208539 doi "https://doi.org/10.1097/qai.0000000000003115" @default.
• W4304208539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36219691" @default.
• W4304208539 hasPublicationYear "2023" @default.
• W4304208539 type Work @default.
• W4304208539 citedByCount "2" @default.
• W4304208539 countsByYear W43042085392023 @default.
• W4304208539 crossrefType "journal-article" @default.
• W4304208539 hasAuthorship W4304208539A5004248801 @default.
• W4304208539 hasAuthorship W4304208539A5006332107 @default.
• W4304208539 hasAuthorship W4304208539A5008758398 @default.
• W4304208539 hasAuthorship W4304208539A5035089475 @default.
• W4304208539 hasAuthorship W4304208539A5049614741 @default.
• W4304208539 hasAuthorship W4304208539A5054715645 @default.
• W4304208539 hasAuthorship W4304208539A5087332112 @default.
• W4304208539 hasConcept C105795698 @default.
• W4304208539 hasConcept C107673813 @default.
• W4304208539 hasConcept C121117317 @default.
• W4304208539 hasConcept C12174686 @default.
• W4304208539 hasConcept C159047783 @default.
• W4304208539 hasConcept C203014093 @default.
• W4304208539 hasConcept C2780014101 @default.
• W4304208539 hasConcept C3013748606 @default.
• W4304208539 hasConcept C33923547 @default.
• W4304208539 hasConcept C38652104 @default.
• W4304208539 hasConcept C41008148 @default.
• W4304208539 hasConcept C71924100 @default.
• W4304208539 hasConcept C761482 @default.
• W4304208539 hasConcept C76155785 @default.
• W4304208539 hasConcept C86803240 @default.
• W4304208539 hasConceptScore W4304208539C105795698 @default.
• W4304208539 hasConceptScore W4304208539C107673813 @default.
• W4304208539 hasConceptScore W4304208539C121117317 @default.
• W4304208539 hasConceptScore W4304208539C12174686 @default.
• W4304208539 hasConceptScore W4304208539C159047783 @default.
• W4304208539 hasConceptScore W4304208539C203014093 @default.
• W4304208539 hasConceptScore W4304208539C2780014101 @default.
• W4304208539 hasConceptScore W4304208539C3013748606 @default.
• W4304208539 hasConceptScore W4304208539C33923547 @default.
• W4304208539 hasConceptScore W4304208539C38652104 @default.
• W4304208539 hasConceptScore W4304208539C41008148 @default.
• W4304208539 hasConceptScore W4304208539C71924100 @default.
• W4304208539 hasConceptScore W4304208539C761482 @default.
• W4304208539 hasConceptScore W4304208539C76155785 @default.
• W4304208539 hasConceptScore W4304208539C86803240 @default.
• W4304208539 hasIssue "2" @default.
• W4304208539 hasLocation W43042085391 @default.
• W4304208539 hasLocation W43042085392 @default.
• W4304208539 hasOpenAccess W4304208539 @default.
• W4304208539 hasPrimaryLocation W43042085391 @default.
• W4304208539 hasRelatedWork W2049655029 @default.
• W4304208539 hasRelatedWork W2158495165 @default.
• W4304208539 hasRelatedWork W2184900176 @default.
• W4304208539 hasRelatedWork W221694431 @default.

• next