FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304587233> ?p ?o ?g. }

• W4304587233 endingPage "5992" @default.
• W4304587233 startingPage "5992" @default.
• W4304587233 abstract "(1) Background: In COVID-19 patients, the occurrence of thromboembolic complications contributes to disease progression and mortality. In patients at increased risk for thrombotic complications, therapeutic enoxaparin should be considered. However, critically ill COVID-19 patients could develop resistance to enoxaparin. Bivalirudin, a thrombin inhibitor, may be an alternative. This pilot multicenter randomized controlled trial aims to ascertain if bivalirudin may reduce the time spent under invasive mechanical ventilation, as compared to enoxaparin. (2) Methods: Intubated COVID-19 patients at risk for thrombo-embolic complications were randomized to receive therapeutic doses of enoxaparin or bivalirudin. We ascertained the time spent under invasive mechanical ventilation during the first 28 days from Intensive Care Unit (ICU) admission. A standardized weaning protocol was implemented in all centers. In addition, we assessed the occurrence of thromboembolic complications, the number of patients requiring percutaneous tracheostomy, the gas exchange, the reintubation rate, the ICU length of stay, the ICU and 28-days mortalities. (3) Results: We enrolled 58 consecutive patients. Bivalirudin did not reduce the time spent under invasive mechanical ventilation as compared to enoxaparin (12 [8; 13] vs. 13 [10; 15] days, respectively; p = 0.078). Thrombotic (p = 0.056) and embolic (p = 0.423) complications, need for tracheostomy (p = 0.423) or reintubation (p = 0.999), the ICU length of stay (p = 0.076) and mortality (p = 0.777) were also similar between treatments. Patients randomized to bivalirudin showed a higher oxygenation at day 7 and 15 after randomization, when compared to enoxaparin group. (4) Conclusions: In intubated COVID-19 patients at increased risk for thromboembolic complications, bivalirudin did not reduce the time spent under invasive mechanical ventilation, nor improved any other clinical outcomes." @default.
• W4304587233 created "2022-10-12" @default.
• W4304587233 creator A5007364231 @default.
• W4304587233 creator A5018390118 @default.
• W4304587233 creator A5042709075 @default.
• W4304587233 creator A5049568623 @default.
• W4304587233 creator A5054988393 @default.
• W4304587233 creator A5056080502 @default.
• W4304587233 creator A5073504844 @default.
• W4304587233 creator A5076098318 @default.
• W4304587233 creator A5088165071 @default.
• W4304587233 date "2022-10-11" @default.
• W4304587233 modified "2023-10-18" @default.
• W4304587233 title "Bivalirudin vs. Enoxaparin in Intubated COVID-19 Patients: A Pilot Multicenter Randomized Controlled Trial" @default.
• W4304587233 cites W1511757448 @default.
• W4304587233 cites W1946073935 @default.
• W4304587233 cites W1970679039 @default.
• W4304587233 cites W1986902970 @default.
• W4304587233 cites W1999841380 @default.
• W4304587233 cites W2081276200 @default.
• W4304587233 cites W2157503523 @default.
• W4304587233 cites W2170892587 @default.
• W4304587233 cites W2753000083 @default.
• W4304587233 cites W2905003681 @default.
• W4304587233 cites W2943492071 @default.
• W4304587233 cites W2968647901 @default.
• W4304587233 cites W3011610993 @default.
• W4304587233 cites W3013393665 @default.
• W4304587233 cites W3013486442 @default.
• W4304587233 cites W3015656121 @default.
• W4304587233 cites W3016123694 @default.
• W4304587233 cites W3016319555 @default.
• W4304587233 cites W3018782743 @default.
• W4304587233 cites W3029172496 @default.
• W4304587233 cites W3030604488 @default.
• W4304587233 cites W3033034878 @default.
• W4304587233 cites W3037467550 @default.
• W4304587233 cites W3038704768 @default.
• W4304587233 cites W3041327402 @default.
• W4304587233 cites W3041985244 @default.
• W4304587233 cites W3045020713 @default.
• W4304587233 cites W3046396978 @default.
• W4304587233 cites W3081515108 @default.
• W4304587233 cites W3093103900 @default.
• W4304587233 cites W3118617067 @default.
• W4304587233 cites W3129128302 @default.
• W4304587233 cites W3134071414 @default.
• W4304587233 cites W3177314963 @default.
• W4304587233 cites W3202637221 @default.
• W4304587233 cites W3206825654 @default.
• W4304587233 cites W3209883120 @default.
• W4304587233 cites W3216695440 @default.
• W4304587233 cites W3216810195 @default.
• W4304587233 cites W4200302412 @default.
• W4304587233 cites W4205922819 @default.
• W4304587233 cites W4221073421 @default.
• W4304587233 cites W4225282306 @default.
• W4304587233 cites W4231969161 @default.
• W4304587233 cites W4282924675 @default.
• W4304587233 cites W4283388812 @default.
• W4304587233 cites W4285726486 @default.
• W4304587233 doi "https://doi.org/10.3390/jcm11205992" @default.
• W4304587233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36294312" @default.
• W4304587233 hasPublicationYear "2022" @default.
• W4304587233 type Work @default.
• W4304587233 citedByCount "2" @default.
• W4304587233 countsByYear W43045872332022 @default.
• W4304587233 countsByYear W43045872332023 @default.
• W4304587233 crossrefType "journal-article" @default.
• W4304587233 hasAuthorship W4304587233A5007364231 @default.
• W4304587233 hasAuthorship W4304587233A5018390118 @default.
• W4304587233 hasAuthorship W4304587233A5042709075 @default.
• W4304587233 hasAuthorship W4304587233A5049568623 @default.
• W4304587233 hasAuthorship W4304587233A5054988393 @default.
• W4304587233 hasAuthorship W4304587233A5056080502 @default.
• W4304587233 hasAuthorship W4304587233A5073504844 @default.
• W4304587233 hasAuthorship W4304587233A5076098318 @default.
• W4304587233 hasAuthorship W4304587233A5088165071 @default.
• W4304587233 hasBestOaLocation W43045872331 @default.
• W4304587233 hasConcept C126322002 @default.
• W4304587233 hasConcept C141071460 @default.
• W4304587233 hasConcept C168563851 @default.
• W4304587233 hasConcept C204243189 @default.
• W4304587233 hasConcept C2775965419 @default.
• W4304587233 hasConcept C2776376669 @default.
• W4304587233 hasConcept C2777080012 @default.
• W4304587233 hasConcept C2777565915 @default.
• W4304587233 hasConcept C2780400711 @default.
• W4304587233 hasConcept C2992435398 @default.
• W4304587233 hasConcept C42219234 @default.
• W4304587233 hasConcept C500558357 @default.
• W4304587233 hasConcept C71924100 @default.
• W4304587233 hasConceptScore W4304587233C126322002 @default.
• W4304587233 hasConceptScore W4304587233C141071460 @default.
• W4304587233 hasConceptScore W4304587233C168563851 @default.
• W4304587233 hasConceptScore W4304587233C204243189 @default.
• W4304587233 hasConceptScore W4304587233C2775965419 @default.
• W4304587233 hasConceptScore W4304587233C2776376669 @default.

• next