FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304620005> ?p ?o ?g. }

• W4304620005 endingPage "340506" @default.
• W4304620005 startingPage "340506" @default.
• W4304620005 abstract "Sebum from sebaceous glands is a rich source of volatile organic compounds (VOCs) that can readily be sampled non-invasively from the surface of skin. The VOC profiles of sebum can then be used to obtain information regarding different medical conditions including diabetes and Parkinson's Disease. However, the effects of sampling approaches and environmental factors on sebum VOC profiles are not established and the confident attribution of VOCs to disease states needs to be free of extraneous influences such as sampling materials and preparatory conditions. Here, we investigated a more standardised skin swab sampling approach for profiling sebum VOCs from healthy human subjects using thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS). Using a standard GC-MS method for the chemical analysis of sebum swabs, a surprisingly high number of VOCs originate from 'blank' medical swab material alone (up to 74 VOCs) and from the ambient environment (up to 29 VOCs) based on control experiments. We found that heat-treatment of medical swabs prior to GC-MS reduced the number of VOCs detected from 'blank' swabs and improved the reproducibility of VOC profiling, however significant VOC absorption can still occur from environmental exposure to ambient air. VOCs identified in 'blank' swabs consisted predominantly of hydrocarbons, esters, and silicon-based compounds and depended strongly on the material used (cotton and polyester-rayon). Environmental VOCs found to absorb to swabs from the ambient air during sampling included 1-butylheptyl-benzene and hexadecanoic acid methyl ester as well as exogenous VOCs such as isopropyl palmitate and isopropyl myristate. In contrast, sebum VOCs consisted primarily of esters, alcohols, ketones, and aldehydes. 23 and 18 VOCs were identified in sebum collected using polyester-rayon and cotton-based medical swabs, respectively, with 14 VOCs common to both swabs. The effect of subject bathing prior to sebum sampling had minimal impact on the VOC profiles. However, individual differences owing to external factors such as skin type, diet, and exercise will likely influence sebum production. This study highlights the importance of using rigorous controls in sebum sampling, and recommendations are provided for future research involving sebum VOC analysis. For example, the use of sebum sample replicates across multiple days, and the use of control swabs during sample collection is required to confirm the origin and reliability of sebum VOCs. It is anticipated that these recommendations in conjunction with a library of well-established VOCs from medical swabs will further strengthen biomarker identification resulting from sebum VOC analysis." @default.
• W4304620005 created "2022-10-12" @default.
• W4304620005 creator A5030436732 @default.
• W4304620005 creator A5033268156 @default.
• W4304620005 creator A5038663511 @default.
• W4304620005 creator A5045582222 @default.
• W4304620005 creator A5046356609 @default.
• W4304620005 creator A5090786602 @default.
• W4304620005 date "2022-11-01" @default.
• W4304620005 modified "2023-10-16" @default.
• W4304620005 title "Identifying robust and reliable volatile organic compounds in human sebum for biomarker discovery" @default.
• W4304620005 cites W1897831097 @default.
• W4304620005 cites W1916836619 @default.
• W4304620005 cites W1963660313 @default.
• W4304620005 cites W1987708040 @default.
• W4304620005 cites W2005339690 @default.
• W4304620005 cites W2021027861 @default.
• W4304620005 cites W2031456513 @default.
• W4304620005 cites W2033813976 @default.
• W4304620005 cites W2037412169 @default.
• W4304620005 cites W2038220946 @default.
• W4304620005 cites W2038552698 @default.
• W4304620005 cites W2042103697 @default.
• W4304620005 cites W2045590251 @default.
• W4304620005 cites W2050031615 @default.
• W4304620005 cites W2051854775 @default.
• W4304620005 cites W2059982453 @default.
• W4304620005 cites W2060571694 @default.
• W4304620005 cites W2061062685 @default.
• W4304620005 cites W2067827657 @default.
• W4304620005 cites W2071627152 @default.
• W4304620005 cites W2082906742 @default.
• W4304620005 cites W2091508025 @default.
• W4304620005 cites W2092132200 @default.
• W4304620005 cites W2102810061 @default.
• W4304620005 cites W2115331954 @default.
• W4304620005 cites W2138280559 @default.
• W4304620005 cites W2141206344 @default.
• W4304620005 cites W2156045784 @default.
• W4304620005 cites W2156178193 @default.
• W4304620005 cites W2161226746 @default.
• W4304620005 cites W2165329227 @default.
• W4304620005 cites W2169063504 @default.
• W4304620005 cites W2508540310 @default.
• W4304620005 cites W2734851832 @default.
• W4304620005 cites W2754977879 @default.
• W4304620005 cites W2792556634 @default.
• W4304620005 cites W2801696608 @default.
• W4304620005 cites W2806075947 @default.
• W4304620005 cites W2864529735 @default.
• W4304620005 cites W2885919156 @default.
• W4304620005 cites W2889115413 @default.
• W4304620005 cites W2891682447 @default.
• W4304620005 cites W2891980971 @default.
• W4304620005 cites W2901548714 @default.
• W4304620005 cites W2906298949 @default.
• W4304620005 cites W2921871079 @default.
• W4304620005 cites W2968498302 @default.
• W4304620005 cites W3043254019 @default.
• W4304620005 cites W3081368700 @default.
• W4304620005 cites W3131628457 @default.
• W4304620005 cites W3137742641 @default.
• W4304620005 cites W3182837217 @default.
• W4304620005 cites W3195868425 @default.
• W4304620005 cites W4210327336 @default.
• W4304620005 cites W4229053843 @default.
• W4304620005 doi "https://doi.org/10.1016/j.aca.2022.340506" @default.
• W4304620005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36283785" @default.
• W4304620005 hasPublicationYear "2022" @default.
• W4304620005 type Work @default.
• W4304620005 citedByCount "1" @default.
• W4304620005 countsByYear W43046200052023 @default.
• W4304620005 crossrefType "journal-article" @default.
• W4304620005 hasAuthorship W4304620005A5030436732 @default.
• W4304620005 hasAuthorship W4304620005A5033268156 @default.
• W4304620005 hasAuthorship W4304620005A5038663511 @default.
• W4304620005 hasAuthorship W4304620005A5045582222 @default.
• W4304620005 hasAuthorship W4304620005A5046356609 @default.
• W4304620005 hasAuthorship W4304620005A5090786602 @default.
• W4304620005 hasConcept C107872376 @default.
• W4304620005 hasConcept C150394285 @default.
• W4304620005 hasConcept C162356407 @default.
• W4304620005 hasConcept C162711632 @default.
• W4304620005 hasConcept C178790620 @default.
• W4304620005 hasConcept C185592680 @default.
• W4304620005 hasConcept C205345274 @default.
• W4304620005 hasConcept C2775850501 @default.
• W4304620005 hasConcept C2777691172 @default.
• W4304620005 hasConcept C2778150766 @default.
• W4304620005 hasConcept C2781059571 @default.
• W4304620005 hasConcept C43617362 @default.
• W4304620005 hasConceptScore W4304620005C107872376 @default.
• W4304620005 hasConceptScore W4304620005C150394285 @default.
• W4304620005 hasConceptScore W4304620005C162356407 @default.
• W4304620005 hasConceptScore W4304620005C162711632 @default.
• W4304620005 hasConceptScore W4304620005C178790620 @default.
• W4304620005 hasConceptScore W4304620005C185592680 @default.
• W4304620005 hasConceptScore W4304620005C205345274 @default.

• next