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• W4304631687 abstract "ObjectivesVarious factors may contribute to youth experimenting with alcohol or other substance use during late childhood that could lead to more frequent use during adolescence and adulthood. Few studies have examined how predictors from multiple domains converge to impact risk for substance use initiation. Random forest analyses were completed on data from the ABCD study to elucidate the multitude of factors that are related to substance use initiation during late childhood.MethodsAt baseline (ages 9-10 years), 8067 children in the ABCD study reported no lifetime substance use (including any experimentation). Substance use initiation was defined as trying any nonprescribed substance (eg, alcohol, tobacco, cannabis, nonprescribed medications) over the 2-year follow-up period. A total of 407 variables from the following categories were included in the random forest model as predictors of substance use initiation: demographics, peer substance use and availability, mental and physical health, culture and environment, biospecimens, neurocognitive functioning, and structural neuroimaging variables.ResultsOver a 2-year follow-up, 792 (9.81%) of substance-naïve children reported trying a substance by age 11 years. The most common substance was alcohol, followed by tobacco and cannabis. Of the top 25 important predictors, 3 were indicators of peer substance use and availability and 22 were structural neuroimaging variables (ie, surface area and volume of lateral occipital lobe and left superior frontal lobe, volume of right inferior temporal lobe and left orbito-frontal lobe, and surface area of right fusiform).ConclusionsA combination of peer substance use and structural neuroimaging indices were among the top predictors of substance use initiation among previously substance-naïve children. Understanding predictors of early substance use experimentation is important for identifying youth who may be more at risk of developing problematic substance use behaviors that may require targeted intervention approaches.SUD, DAM, ADOL ObjectivesVarious factors may contribute to youth experimenting with alcohol or other substance use during late childhood that could lead to more frequent use during adolescence and adulthood. Few studies have examined how predictors from multiple domains converge to impact risk for substance use initiation. Random forest analyses were completed on data from the ABCD study to elucidate the multitude of factors that are related to substance use initiation during late childhood. Various factors may contribute to youth experimenting with alcohol or other substance use during late childhood that could lead to more frequent use during adolescence and adulthood. Few studies have examined how predictors from multiple domains converge to impact risk for substance use initiation. Random forest analyses were completed on data from the ABCD study to elucidate the multitude of factors that are related to substance use initiation during late childhood. MethodsAt baseline (ages 9-10 years), 8067 children in the ABCD study reported no lifetime substance use (including any experimentation). Substance use initiation was defined as trying any nonprescribed substance (eg, alcohol, tobacco, cannabis, nonprescribed medications) over the 2-year follow-up period. A total of 407 variables from the following categories were included in the random forest model as predictors of substance use initiation: demographics, peer substance use and availability, mental and physical health, culture and environment, biospecimens, neurocognitive functioning, and structural neuroimaging variables. At baseline (ages 9-10 years), 8067 children in the ABCD study reported no lifetime substance use (including any experimentation). Substance use initiation was defined as trying any nonprescribed substance (eg, alcohol, tobacco, cannabis, nonprescribed medications) over the 2-year follow-up period. A total of 407 variables from the following categories were included in the random forest model as predictors of substance use initiation: demographics, peer substance use and availability, mental and physical health, culture and environment, biospecimens, neurocognitive functioning, and structural neuroimaging variables. ResultsOver a 2-year follow-up, 792 (9.81%) of substance-naïve children reported trying a substance by age 11 years. The most common substance was alcohol, followed by tobacco and cannabis. Of the top 25 important predictors, 3 were indicators of peer substance use and availability and 22 were structural neuroimaging variables (ie, surface area and volume of lateral occipital lobe and left superior frontal lobe, volume of right inferior temporal lobe and left orbito-frontal lobe, and surface area of right fusiform). Over a 2-year follow-up, 792 (9.81%) of substance-naïve children reported trying a substance by age 11 years. The most common substance was alcohol, followed by tobacco and cannabis. Of the top 25 important predictors, 3 were indicators of peer substance use and availability and 22 were structural neuroimaging variables (ie, surface area and volume of lateral occipital lobe and left superior frontal lobe, volume of right inferior temporal lobe and left orbito-frontal lobe, and surface area of right fusiform). ConclusionsA combination of peer substance use and structural neuroimaging indices were among the top predictors of substance use initiation among previously substance-naïve children. Understanding predictors of early substance use experimentation is important for identifying youth who may be more at risk of developing problematic substance use behaviors that may require targeted intervention approaches.SUD, DAM, ADOL A combination of peer substance use and structural neuroimaging indices were among the top predictors of substance use initiation among previously substance-naïve children. Understanding predictors of early substance use experimentation is important for identifying youth who may be more at risk of developing problematic substance use behaviors that may require targeted intervention approaches." @default.
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• W4304631687 date "2022-10-01" @default.
• W4304631687 modified "2023-09-27" @default.
• W4304631687 title "33.2 Predictors of Substance Use Initiation by Late Childhood: Findings From the ABCD Study" @default.
• W4304631687 doi "https://doi.org/10.1016/j.jaac.2022.07.740" @default.
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