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- W4304632016 endingPage "1174" @default.
- W4304632016 startingPage "1174" @default.
- W4304632016 abstract "In this study, we demonstrate that Trypanosoma cruzi epimastigotes previously grown in LIT medium supplemented with 20 mM galactose and exposed to sub-lethal concentrations of hydrogen peroxide (100 μM) showed two-fold and five-fold viability when compared to epimastigotes grown in LIT medium supplemented with two different glucose concentrations (20 mM and 1.5 mM), respectively. Similar results were obtained when exposing epimastigotes from all treatments to methylene blue 30 μM. Additionally, through differential centrifugation and the selective permeabilization of cellular membranes with digitonin, we found that phosphoglucomutase activity (a key enzyme in galactose metabolism) occurs predominantly within the cytosolic compartment. Furthermore, after partially permeabilizing epimastigotes with digitonin (0.025 mg × mg−1 of protein), intact glycosomes treated with 20 mM galactose released a higher hexose phosphate concentration to the cytosol in the form of glucose-1-phosphate, when compared to intact glycosomes treated with 20 mM glucose, which predominantly released glucose-6-phosphate. These results shine a light on T. cruzi’s galactose metabolism and its interplay with mechanisms that enable resistance to oxidative stress." @default.
- W4304632016 created "2022-10-12" @default.
- W4304632016 creator A5021479695 @default.
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- W4304632016 creator A5049411231 @default.
- W4304632016 creator A5069046374 @default.
- W4304632016 creator A5086746159 @default.
- W4304632016 date "2022-10-11" @default.
- W4304632016 modified "2023-09-27" @default.
- W4304632016 title "Consumption of Galactose by Trypanosoma cruzi Epimastigotes Generates Resistance against Oxidative Stress" @default.
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