Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304687465> ?p ?o ?g. }
- W4304687465 endingPage "248" @default.
- W4304687465 startingPage "239" @default.
- W4304687465 abstract "Background: Diabetic Kidney Disease (DKD) is a significant challenge in healthcare. However, there are currently no reliable biomarkers for renal impairment diagnosis, prognosis, or staging in DKD patients. CircRNAs and microRNAs have emerged as noninvasive and efficient biomarkers. Methods: We explored Cannabinoid receptor 1 (CNR1), C reactive protein (CRP), hsa_circ_ 0000146 and 0000072, and hsa-miR-21 and 495 as diagnostic biomarkers in DKD. The serum concentrations of CRP and CNR1 were measured using ELISA. Rt-qPCR was used to evaluate the expression levels of CNR1, circRNAs, and miRNAs in 55 controls, 55 type 2 diabetes mellitus patients, and 55 DKD patients. Their diagnostic value was determined by their ROC curve. KEGG pathway was used to predict the functional mechanism of the circRNA's target genes. Results: DKD patients exhibited a significant increase in CRP and CNR1 levels and the expression of miR-21 and 495. The expression levels of circ_0000146 and 0000072 decreased in DKD patients. ROC analysis revealed that circRNAs and miRNAs alone or CNR1 and CRP have significant diagnostic potential. The functional prediction results showed the involvement of hsa_circ_0000146 and 0000072 in various pathways that regulate DKD. Conclusions: Therefore, the examined circRNAs and miRNAs may represent a novel noninvasive biomarker for diagnosing and staging DKD." @default.
- W4304687465 created "2022-10-12" @default.
- W4304687465 creator A5007768036 @default.
- W4304687465 creator A5013325341 @default.
- W4304687465 creator A5036324309 @default.
- W4304687465 creator A5038693984 @default.
- W4304687465 creator A5051581938 @default.
- W4304687465 creator A5080386788 @default.
- W4304687465 creator A5080884145 @default.
- W4304687465 date "2023-01-01" @default.
- W4304687465 modified "2023-10-12" @default.
- W4304687465 title "Diagnostic significance of hsa_circ_0000146 and hsa_circ_0000072 biomarkers for Diabetic Kidney Disease in patients with type 2 diabetes mellitus" @default.
- W4304687465 cites W2058835062 @default.
- W4304687465 cites W2062361442 @default.
- W4304687465 cites W2110135514 @default.
- W4304687465 cites W2120852510 @default.
- W4304687465 cites W2143132516 @default.
- W4304687465 cites W2160432504 @default.
- W4304687465 cites W2224972419 @default.
- W4304687465 cites W2525587647 @default.
- W4304687465 cites W2568946527 @default.
- W4304687465 cites W2596125809 @default.
- W4304687465 cites W2763511716 @default.
- W4304687465 cites W2768055940 @default.
- W4304687465 cites W2769323473 @default.
- W4304687465 cites W2794295407 @default.
- W4304687465 cites W2884057849 @default.
- W4304687465 cites W2884186955 @default.
- W4304687465 cites W2943314527 @default.
- W4304687465 cites W2966811446 @default.
- W4304687465 cites W2997391649 @default.
- W4304687465 cites W3007827907 @default.
- W4304687465 cites W3014721260 @default.
- W4304687465 cites W3023079484 @default.
- W4304687465 cites W3030473668 @default.
- W4304687465 cites W3031670847 @default.
- W4304687465 cites W3048379517 @default.
- W4304687465 cites W3119860360 @default.
- W4304687465 cites W3121261712 @default.
- W4304687465 cites W3127243504 @default.
- W4304687465 cites W3128504694 @default.
- W4304687465 cites W3181073962 @default.
- W4304687465 cites W3198473100 @default.
- W4304687465 cites W4205128222 @default.
- W4304687465 doi "https://doi.org/10.5937/jomb0-39361" @default.
- W4304687465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36987415" @default.
- W4304687465 hasPublicationYear "2023" @default.
- W4304687465 type Work @default.
- W4304687465 citedByCount "0" @default.
- W4304687465 crossrefType "journal-article" @default.
- W4304687465 hasAuthorship W4304687465A5007768036 @default.
- W4304687465 hasAuthorship W4304687465A5013325341 @default.
- W4304687465 hasAuthorship W4304687465A5036324309 @default.
- W4304687465 hasAuthorship W4304687465A5038693984 @default.
- W4304687465 hasAuthorship W4304687465A5051581938 @default.
- W4304687465 hasAuthorship W4304687465A5080386788 @default.
- W4304687465 hasAuthorship W4304687465A5080884145 @default.
- W4304687465 hasBestOaLocation W43046874651 @default.
- W4304687465 hasConcept C104317684 @default.
- W4304687465 hasConcept C121608353 @default.
- W4304687465 hasConcept C126322002 @default.
- W4304687465 hasConcept C134018914 @default.
- W4304687465 hasConcept C142724271 @default.
- W4304687465 hasConcept C143998085 @default.
- W4304687465 hasConcept C145059251 @default.
- W4304687465 hasConcept C2778653478 @default.
- W4304687465 hasConcept C2779134260 @default.
- W4304687465 hasConcept C2781197716 @default.
- W4304687465 hasConcept C2910068830 @default.
- W4304687465 hasConcept C3017616150 @default.
- W4304687465 hasConcept C55493867 @default.
- W4304687465 hasConcept C555293320 @default.
- W4304687465 hasConcept C60644358 @default.
- W4304687465 hasConcept C71924100 @default.
- W4304687465 hasConcept C86803240 @default.
- W4304687465 hasConcept C90924648 @default.
- W4304687465 hasConceptScore W4304687465C104317684 @default.
- W4304687465 hasConceptScore W4304687465C121608353 @default.
- W4304687465 hasConceptScore W4304687465C126322002 @default.
- W4304687465 hasConceptScore W4304687465C134018914 @default.
- W4304687465 hasConceptScore W4304687465C142724271 @default.
- W4304687465 hasConceptScore W4304687465C143998085 @default.
- W4304687465 hasConceptScore W4304687465C145059251 @default.
- W4304687465 hasConceptScore W4304687465C2778653478 @default.
- W4304687465 hasConceptScore W4304687465C2779134260 @default.
- W4304687465 hasConceptScore W4304687465C2781197716 @default.
- W4304687465 hasConceptScore W4304687465C2910068830 @default.
- W4304687465 hasConceptScore W4304687465C3017616150 @default.
- W4304687465 hasConceptScore W4304687465C55493867 @default.
- W4304687465 hasConceptScore W4304687465C555293320 @default.
- W4304687465 hasConceptScore W4304687465C60644358 @default.
- W4304687465 hasConceptScore W4304687465C71924100 @default.
- W4304687465 hasConceptScore W4304687465C86803240 @default.
- W4304687465 hasConceptScore W4304687465C90924648 @default.
- W4304687465 hasIssue "2" @default.
- W4304687465 hasLocation W43046874651 @default.
- W4304687465 hasLocation W43046874652 @default.
- W4304687465 hasLocation W43046874653 @default.