FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304687580> ?p ?o ?g. }

• W4304687580 abstract "Huntington's disease manifests due to abnormal CAG trinucleotide expansion, in the first exon of the Huntingtin gene and disease progression involves genetic, immune, and environmental components. The pathogenesis is characterized by the formation of Inclusion Bodies, disruption of neuronal circuitry, cellular machinery, and apoptosis, resulting in gradual and progressive loss of neuronal cells, ultimately leading to nervous system dysfunction. Thus, the present study was conducted to assess the effect of two Ayurvedic formulations, Guduchi and Madhuyashti, on Huntington's phenotype, using Drosophila as a model system.The Huntington phenotype was ectopically induced in the Drosophila eye using the UAS-GAL4 binary system and the effect of the two Ayurvedic formulations were assessed by feeding the progenies on them. Degeneration was observed microscopically and Real Time-PCR was done to assay the alterations in the different transcripts of the innate immune pathways and JNK signaling pathway. Immunostaining was performed to assay different gene expression patterns.The present study shows that Guduchi and Madhuyashti, endowed with immunomodulatory and intellect promoting properties, aggravates polyQ mediated neurodegeneration. We provide evidence that these formulations enhance JNK signaling by activating the MAP 3 K, dTAK1, which regulates the expression of Drosophila homologue for JNK. Sustained, rather than a transient expression of JNK leads to excessive production of Anti-Microbial Peptides without involving the canonical transcription factors of the Toll or IMD pathways, NF-κB. Enhanced JNK expression also increases caspase levels, with a concomitant reduction in cell proliferation, which may further contribute to increased degeneration.This is a report linking the functional relevance of Guduchi and Madhuyashti with molecular pathways, which can be important for understanding their use in therapeutic applications and holds promise for mechanistic insight into the mammalian counterpart." @default.
• W4304687580 created "2022-10-12" @default.
• W4304687580 creator A5019936652 @default.
• W4304687580 creator A5037149091 @default.
• W4304687580 date "2022-10-12" @default.
• W4304687580 modified "2023-10-09" @default.
• W4304687580 title "Ayurvedic formulations Guduchi and Madhuyashti triggers JNK signaling mediated immune response and adversely affects Huntington phenotype" @default.
• W4304687580 cites W1877842980 @default.
• W4304687580 cites W1961449438 @default.
• W4304687580 cites W1965394539 @default.
• W4304687580 cites W1969342645 @default.
• W4304687580 cites W1971462418 @default.
• W4304687580 cites W1974947562 @default.
• W4304687580 cites W1977023068 @default.
• W4304687580 cites W1982264720 @default.
• W4304687580 cites W1990248374 @default.
• W4304687580 cites W1995335649 @default.
• W4304687580 cites W2023331434 @default.
• W4304687580 cites W2030791386 @default.
• W4304687580 cites W2033586457 @default.
• W4304687580 cites W2039270608 @default.
• W4304687580 cites W2043263502 @default.
• W4304687580 cites W2050138776 @default.
• W4304687580 cites W2050339595 @default.
• W4304687580 cites W2050663806 @default.
• W4304687580 cites W2063702713 @default.
• W4304687580 cites W2076515532 @default.
• W4304687580 cites W2083282789 @default.
• W4304687580 cites W2093036824 @default.
• W4304687580 cites W2117775547 @default.
• W4304687580 cites W2132103131 @default.
• W4304687580 cites W2134022293 @default.
• W4304687580 cites W2137817844 @default.
• W4304687580 cites W2156242099 @default.
• W4304687580 cites W2156739718 @default.
• W4304687580 cites W2169057762 @default.
• W4304687580 cites W2257129080 @default.
• W4304687580 cites W2528989946 @default.
• W4304687580 cites W2553326946 @default.
• W4304687580 cites W2577038178 @default.
• W4304687580 cites W2735217968 @default.
• W4304687580 cites W2895548446 @default.
• W4304687580 cites W2903122844 @default.
• W4304687580 cites W2923204461 @default.
• W4304687580 cites W3091792773 @default.
• W4304687580 cites W4244779656 @default.
• W4304687580 cites W4383673615 @default.
• W4304687580 doi "https://doi.org/10.1186/s12906-022-03724-9" @default.
• W4304687580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36224586" @default.
• W4304687580 hasPublicationYear "2022" @default.
• W4304687580 type Work @default.
• W4304687580 citedByCount "0" @default.
• W4304687580 crossrefType "journal-article" @default.
• W4304687580 hasAuthorship W4304687580A5019936652 @default.
• W4304687580 hasAuthorship W4304687580A5037149091 @default.
• W4304687580 hasBestOaLocation W43046875801 @default.
• W4304687580 hasConcept C104317684 @default.
• W4304687580 hasConcept C126322002 @default.
• W4304687580 hasConcept C127716648 @default.
• W4304687580 hasConcept C136449434 @default.
• W4304687580 hasConcept C143065580 @default.
• W4304687580 hasConcept C203014093 @default.
• W4304687580 hasConcept C2776925932 @default.
• W4304687580 hasConcept C2779134260 @default.
• W4304687580 hasConcept C2780647506 @default.
• W4304687580 hasConcept C2781427258 @default.
• W4304687580 hasConcept C54355233 @default.
• W4304687580 hasConcept C62478195 @default.
• W4304687580 hasConcept C71924100 @default.
• W4304687580 hasConcept C86803240 @default.
• W4304687580 hasConcept C8891405 @default.
• W4304687580 hasConcept C95444343 @default.
• W4304687580 hasConceptScore W4304687580C104317684 @default.
• W4304687580 hasConceptScore W4304687580C126322002 @default.
• W4304687580 hasConceptScore W4304687580C127716648 @default.
• W4304687580 hasConceptScore W4304687580C136449434 @default.
• W4304687580 hasConceptScore W4304687580C143065580 @default.
• W4304687580 hasConceptScore W4304687580C203014093 @default.
• W4304687580 hasConceptScore W4304687580C2776925932 @default.
• W4304687580 hasConceptScore W4304687580C2779134260 @default.
• W4304687580 hasConceptScore W4304687580C2780647506 @default.
• W4304687580 hasConceptScore W4304687580C2781427258 @default.
• W4304687580 hasConceptScore W4304687580C54355233 @default.
• W4304687580 hasConceptScore W4304687580C62478195 @default.
• W4304687580 hasConceptScore W4304687580C71924100 @default.
• W4304687580 hasConceptScore W4304687580C86803240 @default.
• W4304687580 hasConceptScore W4304687580C8891405 @default.
• W4304687580 hasConceptScore W4304687580C95444343 @default.
• W4304687580 hasFunder F4320320720 @default.
• W4304687580 hasFunder F4320334771 @default.
• W4304687580 hasIssue "1" @default.
• W4304687580 hasLocation W43046875801 @default.
• W4304687580 hasLocation W43046875802 @default.
• W4304687580 hasLocation W43046875803 @default.
• W4304687580 hasLocation W43046875804 @default.
• W4304687580 hasOpenAccess W4304687580 @default.
• W4304687580 hasPrimaryLocation W43046875801 @default.
• W4304687580 hasRelatedWork W143538493 @default.
• W4304687580 hasRelatedWork W2046844414 @default.
• W4304687580 hasRelatedWork W2086262835 @default.

• next