FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304687637> ?p ?o ?g. }

• W4304687637 endingPage "121" @default.
• W4304687637 startingPage "108" @default.
• W4304687637 abstract "Doxorubicin (DOX), a clinical chemotherapeutic drug, is often annoyed by its cardiotoxicity which involves ferroptosis in its pathological progress. Human umbilical cord mesenchymal stem cells (HucMSCs)-derived exosomes (HucMSCs-Exo) are proven effective in treating cardiovascular diseases. This study aimed to compare the therapeutic effects between normoxic HucMSCs-Exo (Exo) and hypoxic HucMSCs-Exo (Hypo-Exo) on DOX-induced ferroptosis and explore the underlying mechanisms. An acute cardiotoxicity model was successfully constructed by administrating two doses intraperitoneal injections of DOX (25 mg/kg in total). Exo and Hypo-Exo were extracted by ultracentrifugation and characterized. Compared with Exo, Hypo-Exo and Ferrostatin-1 (Fer-1) exerted superior effects on inhibiting DOX-induced ferroptosis, as evidenced by decreasing malondialdehyde (MDA), iron content and increasing glutathione (GSH) level as well as ferroptosis-related genes expression including prostaglandin-endoperoxide synthase 2 (Ptgs2) mRNA level and glutathione peroxidase 4 (GPX4) protein level. Based on quantitative proteomics analysis, we found that thioredoxin1 (Trx1) was remarkably upregulated in Hypo-Exo and exhibited anti-ferroptosis activity via activating the mechanistic target of rapamycin complex 1 (mTORC1) in neonatal rat cardiomyocytes (NRCMs). Trx1 knockdown and rapamycin (an mTORC1 inhibitor) partially abolished the protective effects of Hypo-Exo. Furthermore, our data indicated that solute carrier family 7 member 11 (SLC7A11) was critical for GPX4 protein synthesis. In conclusion, Hypo-Exo exhibited a better suppression of ferroptosis in DOX-induced cardiotoxicity. Trx1-mediated mTORC1 activation is critical for the Hypo-Exo anti-ferroptosis process, which involves increased GPX4 protein synthesis and decreased iron overload. This study indicated that Hypo-Exo may present a potential strategy against ferroptosis in DOX-induced cardiotoxicity." @default.
• W4304687637 created "2022-10-12" @default.
• W4304687637 creator A5004229911 @default.
• W4304687637 creator A5014840053 @default.
• W4304687637 creator A5042119018 @default.
• W4304687637 creator A5049816813 @default.
• W4304687637 creator A5053467487 @default.
• W4304687637 creator A5054630369 @default.
• W4304687637 creator A5057209439 @default.
• W4304687637 creator A5074844292 @default.
• W4304687637 creator A5076119932 @default.
• W4304687637 creator A5079266488 @default.
• W4304687637 creator A5091778076 @default.
• W4304687637 date "2022-11-01" @default.
• W4304687637 modified "2023-10-18" @default.
• W4304687637 title "Exosomal thioredoxin-1 from hypoxic human umbilical cord mesenchymal stem cells inhibits ferroptosis in doxorubicin-induced cardiotoxicity via mTORC1 signaling" @default.
• W4304687637 cites W1492360552 @default.
• W4304687637 cites W1589421810 @default.
• W4304687637 cites W1987743024 @default.
• W4304687637 cites W1997183854 @default.
• W4304687637 cites W2000462205 @default.
• W4304687637 cites W2005408885 @default.
• W4304687637 cites W2023483654 @default.
• W4304687637 cites W2030744504 @default.
• W4304687637 cites W2032661669 @default.
• W4304687637 cites W2035898183 @default.
• W4304687637 cites W2050083026 @default.
• W4304687637 cites W2065562721 @default.
• W4304687637 cites W2102897174 @default.
• W4304687637 cites W2127063807 @default.
• W4304687637 cites W2157039258 @default.
• W4304687637 cites W2170466989 @default.
• W4304687637 cites W2231291760 @default.
• W4304687637 cites W2296538017 @default.
• W4304687637 cites W2593816418 @default.
• W4304687637 cites W2605404328 @default.
• W4304687637 cites W2756768485 @default.
• W4304687637 cites W2767876404 @default.
• W4304687637 cites W2804834775 @default.
• W4304687637 cites W2903201035 @default.
• W4304687637 cites W2914574872 @default.
• W4304687637 cites W2978903584 @default.
• W4304687637 cites W2999421965 @default.
• W4304687637 cites W3013936205 @default.
• W4304687637 cites W3014424278 @default.
• W4304687637 cites W3020990397 @default.
• W4304687637 cites W3021429039 @default.
• W4304687637 cites W3080682519 @default.
• W4304687637 cites W3080741609 @default.
• W4304687637 cites W3093376324 @default.
• W4304687637 cites W3097462093 @default.
• W4304687637 cites W3103898859 @default.
• W4304687637 cites W3109926818 @default.
• W4304687637 cites W3128556472 @default.
• W4304687637 cites W3178415436 @default.
• W4304687637 cites W3179553680 @default.
• W4304687637 cites W3198197865 @default.
• W4304687637 cites W3207867512 @default.
• W4304687637 cites W4200359164 @default.
• W4304687637 cites W4238361207 @default.
• W4304687637 cites W4247896860 @default.
• W4304687637 doi "https://doi.org/10.1016/j.freeradbiomed.2022.10.268" @default.
• W4304687637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36241072" @default.
• W4304687637 hasPublicationYear "2022" @default.
• W4304687637 type Work @default.
• W4304687637 citedByCount "9" @default.
• W4304687637 countsByYear W43046876372023 @default.
• W4304687637 crossrefType "journal-article" @default.
• W4304687637 hasAuthorship W4304687637A5004229911 @default.
• W4304687637 hasAuthorship W4304687637A5014840053 @default.
• W4304687637 hasAuthorship W4304687637A5042119018 @default.
• W4304687637 hasAuthorship W4304687637A5049816813 @default.
• W4304687637 hasAuthorship W4304687637A5053467487 @default.
• W4304687637 hasAuthorship W4304687637A5054630369 @default.
• W4304687637 hasAuthorship W4304687637A5057209439 @default.
• W4304687637 hasAuthorship W4304687637A5074844292 @default.
• W4304687637 hasAuthorship W4304687637A5076119932 @default.
• W4304687637 hasAuthorship W4304687637A5079266488 @default.
• W4304687637 hasAuthorship W4304687637A5091778076 @default.
• W4304687637 hasConcept C126322002 @default.
• W4304687637 hasConcept C158086472 @default.
• W4304687637 hasConcept C178790620 @default.
• W4304687637 hasConcept C181199279 @default.
• W4304687637 hasConcept C185592680 @default.
• W4304687637 hasConcept C198826908 @default.
• W4304687637 hasConcept C2775838275 @default.
• W4304687637 hasConcept C2776151105 @default.
• W4304687637 hasConcept C2776694085 @default.
• W4304687637 hasConcept C2778233292 @default.
• W4304687637 hasConcept C2778401633 @default.
• W4304687637 hasConcept C2778760513 @default.
• W4304687637 hasConcept C2781303535 @default.
• W4304687637 hasConcept C29730261 @default.
• W4304687637 hasConcept C502942594 @default.
• W4304687637 hasConcept C538909803 @default.
• W4304687637 hasConcept C55493867 @default.
• W4304687637 hasConcept C71924100 @default.
• W4304687637 hasConcept C86803240 @default.

• next