Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304687650> ?p ?o ?g. }
- W4304687650 endingPage "110490" @default.
- W4304687650 startingPage "110490" @default.
- W4304687650 abstract "PSMD14/POH1/Rpn11 plays a crucial role in cellular homeostasis. PSMD14 is a structural subunit of the lid subcomplex of the proteasome 19S regulatory particle with constitutive deubiquitinase activity. Canonically, PSMD14 removes the full ubiquitin chains with K48-linkages by hydrolyzing the isopeptide bond between the substrate and the C-terminus of the first ubiquitin, a crucial step for the entry of substrates into the catalytic barrel of the 20S proteasome and their subsequent degradation, all in context of the 26S proteasome. However, more recent discoveries indicate PSMD14 DUB activity is not only coupled to the translocation of substrates into the core of 20S proteasome. During the assembly of the lid, activity of PSMD14 has been detected in the context of the heterodimer with PSMD7. Additionally, assembly of the lid subcomplex occurs as an independent event of the base subcomplex and 20S proteasome. This feature opens the possibility that the regulatory particle, free lid subcomplex or the heterodimer PSMD14-PSMD7 might play other physiological roles including a positive function on protein stability through deubiquitination. Here we discuss scenarios that could enhance this PSMD14 non-canonical pathway, the potential impact in preventing degradation of substrates by autophagy highlighting the main findings that support this hypothesis. Finally, we discuss why this information should be investigated in biomedicine specifically with focus on cancer progression to design new therapeutic strategies against the lid subcomplex and the heterodimer PSMD14-PSMD7, highlighting PSMD14 as a druggable target for cancer therapy." @default.
- W4304687650 created "2022-10-12" @default.
- W4304687650 creator A5009779793 @default.
- W4304687650 creator A5009965939 @default.
- W4304687650 creator A5029452323 @default.
- W4304687650 creator A5050621605 @default.
- W4304687650 creator A5088451627 @default.
- W4304687650 date "2023-01-01" @default.
- W4304687650 modified "2023-10-10" @default.
- W4304687650 title "Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression" @default.
- W4304687650 cites W12673267 @default.
- W4304687650 cites W1509052415 @default.
- W4304687650 cites W1530611492 @default.
- W4304687650 cites W1552171878 @default.
- W4304687650 cites W1851733051 @default.
- W4304687650 cites W1978403153 @default.
- W4304687650 cites W1982166284 @default.
- W4304687650 cites W1987667299 @default.
- W4304687650 cites W1992174702 @default.
- W4304687650 cites W1999523595 @default.
- W4304687650 cites W2007277647 @default.
- W4304687650 cites W2010558905 @default.
- W4304687650 cites W2016151751 @default.
- W4304687650 cites W2038751264 @default.
- W4304687650 cites W2044347239 @default.
- W4304687650 cites W2054446345 @default.
- W4304687650 cites W2060354742 @default.
- W4304687650 cites W2085175631 @default.
- W4304687650 cites W2088724822 @default.
- W4304687650 cites W2108279225 @default.
- W4304687650 cites W2114873132 @default.
- W4304687650 cites W2129020264 @default.
- W4304687650 cites W2143375105 @default.
- W4304687650 cites W2144593863 @default.
- W4304687650 cites W2146349416 @default.
- W4304687650 cites W2148566355 @default.
- W4304687650 cites W2149761960 @default.
- W4304687650 cites W2150123812 @default.
- W4304687650 cites W2150416393 @default.
- W4304687650 cites W2157495054 @default.
- W4304687650 cites W2162223351 @default.
- W4304687650 cites W2164253678 @default.
- W4304687650 cites W2166790177 @default.
- W4304687650 cites W2174194526 @default.
- W4304687650 cites W2225782005 @default.
- W4304687650 cites W2270285613 @default.
- W4304687650 cites W2477420580 @default.
- W4304687650 cites W2484335322 @default.
- W4304687650 cites W2592937673 @default.
- W4304687650 cites W2615219661 @default.
- W4304687650 cites W2622381363 @default.
- W4304687650 cites W2749554293 @default.
- W4304687650 cites W2782887875 @default.
- W4304687650 cites W2789451531 @default.
- W4304687650 cites W2798011605 @default.
- W4304687650 cites W2856385059 @default.
- W4304687650 cites W2905703306 @default.
- W4304687650 cites W2910722456 @default.
- W4304687650 cites W2913774041 @default.
- W4304687650 cites W2940254466 @default.
- W4304687650 cites W2947163501 @default.
- W4304687650 cites W2949934667 @default.
- W4304687650 cites W2953191511 @default.
- W4304687650 cites W2954363248 @default.
- W4304687650 cites W2968272978 @default.
- W4304687650 cites W2980546791 @default.
- W4304687650 cites W2987388494 @default.
- W4304687650 cites W3012597523 @default.
- W4304687650 cites W3012930547 @default.
- W4304687650 cites W3032631374 @default.
- W4304687650 cites W3119775561 @default.
- W4304687650 cites W3127534046 @default.
- W4304687650 cites W3156283553 @default.
- W4304687650 cites W3177044865 @default.
- W4304687650 cites W3192784650 @default.
- W4304687650 cites W4211233744 @default.
- W4304687650 cites W4223566815 @default.
- W4304687650 cites W4225273207 @default.
- W4304687650 doi "https://doi.org/10.1016/j.cellsig.2022.110490" @default.
- W4304687650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36241058" @default.
- W4304687650 hasPublicationYear "2023" @default.
- W4304687650 type Work @default.
- W4304687650 citedByCount "3" @default.
- W4304687650 countsByYear W43046876502023 @default.
- W4304687650 crossrefType "journal-article" @default.
- W4304687650 hasAuthorship W4304687650A5009779793 @default.
- W4304687650 hasAuthorship W4304687650A5009965939 @default.
- W4304687650 hasAuthorship W4304687650A5029452323 @default.
- W4304687650 hasAuthorship W4304687650A5050621605 @default.
- W4304687650 hasAuthorship W4304687650A5088451627 @default.
- W4304687650 hasConcept C102658986 @default.
- W4304687650 hasConcept C104292427 @default.
- W4304687650 hasConcept C104317684 @default.
- W4304687650 hasConcept C151730666 @default.
- W4304687650 hasConcept C185592680 @default.
- W4304687650 hasConcept C25602115 @default.
- W4304687650 hasConcept C27740335 @default.
- W4304687650 hasConcept C2779343474 @default.