FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304687992> ?p ?o ?g. }

• W4304687992 endingPage "106503" @default.
• W4304687992 startingPage "106503" @default.
• W4304687992 abstract "Acute myeloid leukemia (AML) is featured with poor prognosis and high mortality, because chemo-resistance, nonspecific distribution and dose-limiting toxicity lead to a high rate of relapse and a very low 5-year survival percentage of less than 25%. CXCR4 is a highly expressed chemokine receptor in multiple types of AML cells and closely associated with the drug resistance and relapse. In this work, we integrate a chemically synthesized CXCR4 antagonistic peptide and doxorubicin using DSPE-mPEG2000 micelles (referred to as M-E5-Dox) that is applied to a very challenging refractory AML mouse model as well as human AML cell lines. Results showed that M-E5-Dox can effectively bind to the CXCR4-expressing AML cells, downregulating the signaling proteins mediated by CXCR4/CXCL12 axis and increasing the cellular uptake of Dox. Importantly, M-E5-Dox remarkably decreases the leukemic cells in the peripheral blood and bone marrow, as well as their infiltration in the spleen and liver of the AML mice, which in turn prolongs the survival significantly. Meanwhile, M-E5-Dox did not increase the cardiotoxicity of Dox. In conclusion, M-E5-Dox harnesses the functions of CXCR4 specific binding and CXCR4 antagonism of the peptide and the tumor cell killing capacity of Dox, which displays significant therapeutic effects and promising translational potentials for the treatment of refractory AML." @default.
• W4304687992 created "2022-10-12" @default.
• W4304687992 creator A5012787587 @default.
• W4304687992 creator A5012931311 @default.
• W4304687992 creator A5013038112 @default.
• W4304687992 creator A5017482227 @default.
• W4304687992 creator A5022679996 @default.
• W4304687992 creator A5026171887 @default.
• W4304687992 creator A5029695574 @default.
• W4304687992 creator A5035677923 @default.
• W4304687992 creator A5038779010 @default.
• W4304687992 creator A5052064098 @default.
• W4304687992 creator A5060165452 @default.
• W4304687992 creator A5065543394 @default.
• W4304687992 date "2022-11-01" @default.
• W4304687992 modified "2023-10-17" @default.
• W4304687992 title "Nanomicelles co-loading CXCR4 antagonist and doxorubicin combat the refractory acute myeloid leukemia" @default.
• W4304687992 cites W1438161774 @default.
• W4304687992 cites W1974250949 @default.
• W4304687992 cites W1985451396 @default.
• W4304687992 cites W2000798536 @default.
• W4304687992 cites W2000980282 @default.
• W4304687992 cites W2023624246 @default.
• W4304687992 cites W2043046186 @default.
• W4304687992 cites W2044088883 @default.
• W4304687992 cites W2044942890 @default.
• W4304687992 cites W2074014167 @default.
• W4304687992 cites W2085328048 @default.
• W4304687992 cites W2094562568 @default.
• W4304687992 cites W2107401114 @default.
• W4304687992 cites W2128645075 @default.
• W4304687992 cites W2129144690 @default.
• W4304687992 cites W2139559272 @default.
• W4304687992 cites W2140382736 @default.
• W4304687992 cites W2144672860 @default.
• W4304687992 cites W2149888039 @default.
• W4304687992 cites W2166446553 @default.
• W4304687992 cites W2170846829 @default.
• W4304687992 cites W2179176827 @default.
• W4304687992 cites W2237124828 @default.
• W4304687992 cites W2328418253 @default.
• W4304687992 cites W2405289692 @default.
• W4304687992 cites W2520053757 @default.
• W4304687992 cites W2570618306 @default.
• W4304687992 cites W2593366005 @default.
• W4304687992 cites W2621129641 @default.
• W4304687992 cites W2621360341 @default.
• W4304687992 cites W2743142984 @default.
• W4304687992 cites W2746461465 @default.
• W4304687992 cites W2771708376 @default.
• W4304687992 cites W2806693786 @default.
• W4304687992 cites W2883873335 @default.
• W4304687992 cites W2892491493 @default.
• W4304687992 cites W2896480326 @default.
• W4304687992 cites W2921577938 @default.
• W4304687992 cites W2991739243 @default.
• W4304687992 cites W3005220199 @default.
• W4304687992 cites W3005295900 @default.
• W4304687992 cites W3038313191 @default.
• W4304687992 cites W3039521618 @default.
• W4304687992 cites W3110109496 @default.
• W4304687992 cites W3138670192 @default.
• W4304687992 cites W4247268236 @default.
• W4304687992 cites W903538695 @default.
• W4304687992 doi "https://doi.org/10.1016/j.phrs.2022.106503" @default.
• W4304687992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36241000" @default.
• W4304687992 hasPublicationYear "2022" @default.
• W4304687992 type Work @default.
• W4304687992 citedByCount "2" @default.
• W4304687992 countsByYear W43046879922023 @default.
• W4304687992 crossrefType "journal-article" @default.
• W4304687992 hasAuthorship W4304687992A5012787587 @default.
• W4304687992 hasAuthorship W4304687992A5012931311 @default.
• W4304687992 hasAuthorship W4304687992A5013038112 @default.
• W4304687992 hasAuthorship W4304687992A5017482227 @default.
• W4304687992 hasAuthorship W4304687992A5022679996 @default.
• W4304687992 hasAuthorship W4304687992A5026171887 @default.
• W4304687992 hasAuthorship W4304687992A5029695574 @default.
• W4304687992 hasAuthorship W4304687992A5035677923 @default.
• W4304687992 hasAuthorship W4304687992A5038779010 @default.
• W4304687992 hasAuthorship W4304687992A5052064098 @default.
• W4304687992 hasAuthorship W4304687992A5060165452 @default.
• W4304687992 hasAuthorship W4304687992A5065543394 @default.
• W4304687992 hasConcept C126322002 @default.
• W4304687992 hasConcept C12823836 @default.
• W4304687992 hasConcept C129470790 @default.
• W4304687992 hasConcept C13373296 @default.
• W4304687992 hasConcept C170493617 @default.
• W4304687992 hasConcept C203014093 @default.
• W4304687992 hasConcept C2776694085 @default.
• W4304687992 hasConcept C2778233292 @default.
• W4304687992 hasConcept C2778461978 @default.
• W4304687992 hasConcept C2778729363 @default.
• W4304687992 hasConcept C2780007613 @default.
• W4304687992 hasConcept C2780492938 @default.
• W4304687992 hasConcept C2780931953 @default.
• W4304687992 hasConcept C2781303535 @default.
• W4304687992 hasConcept C502942594 @default.

• next