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- W4304688321 endingPage "3201" @default.
- W4304688321 startingPage "3201" @default.
- W4304688321 abstract "The amyloid cascade hypothesis has predominately been used to describe the pathogenesis of Alzheimer's disease (AD) for decades, as Aβ oligomers are thought to be the prime cause of AD. Meanwhile, the neurotrophic factor hypothesis has also been proposed for decades. Accumulating evidence states that the amyloidogenic process and neurotrophic dysfunction are mutually influenced and may coincidently cause the onset and progress of AD. Meanwhile, there are intracellular regulators participating both in the amyloidogenic process and neurotrophic pathways, which might be the common original causes of amyloidogenesis and neurotrophic dysfunction. In this review, the current understanding regarding the role of neurotrophic dysfunction and the amyloidogenic process in AD pathology is briefly summarized. The mutual influence of these two pathogenesis pathways and their potential common causal pathway are further discussed. Therapeutic strategies targeting the common pathways to simultaneously prevent amyloidogenesis and neurotrophic dysfunction might be anticipated for the disease-modifying treatment of AD." @default.
- W4304688321 created "2022-10-12" @default.
- W4304688321 creator A5034102073 @default.
- W4304688321 creator A5043142151 @default.
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- W4304688321 creator A5070332911 @default.
- W4304688321 creator A5077285017 @default.
- W4304688321 creator A5088254472 @default.
- W4304688321 date "2022-10-12" @default.
- W4304688321 modified "2023-10-16" @default.
- W4304688321 title "Amyloidogenesis and Neurotrophic Dysfunction in Alzheimer’s Disease: Do They have a Common Regulating Pathway?" @default.
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