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- W4304688766 abstract "Intra-tumor heterogeneity (ITH) is a pan-cancer predictor of survival, with high ITH being correlated to a dismal prognosis. The level of ITH is, hence, a clinically relevant characteristic of a malignancy. ITH of karyotypes is driven by chromosomal instability (CIN). However, not all new karyotypes generated by CIN are viable or competitive, which limits the amount of ITH. Here, we review the cellular processes and ecological properties that determine karyotype ITH. We propose a framework to understand karyotype ITH, in which cells with new karyotypes emerge through CIN, are selected by cell intrinsic and cell extrinsic selective pressures, and propagate through a cancer in competition with other malignant cells. We further discuss how CIN modulates the cell phenotype and immune microenvironment, and the implications this has for the subsequent selection of karyotypes. Together, we aim to provide a comprehensive overview of the biological processes that shape the level of karyotype heterogeneity." @default.
- W4304688766 created "2022-10-12" @default.
- W4304688766 creator A5020041765 @default.
- W4304688766 creator A5041052220 @default.
- W4304688766 creator A5048096504 @default.
- W4304688766 date "2022-10-12" @default.
- W4304688766 modified "2023-10-14" @default.
- W4304688766 title "Chromosomal Instability, Selection and Competition: Factors That Shape the Level of Karyotype Intra-Tumor Heterogeneity" @default.
- W4304688766 cites W1442570190 @default.
- W4304688766 cites W1529934215 @default.
- W4304688766 cites W1535432763 @default.
- W4304688766 cites W1690531714 @default.
- W4304688766 cites W1895714488 @default.
- W4304688766 cites W1909830141 @default.
- W4304688766 cites W1967220865 @default.
- W4304688766 cites W1967304777 @default.
- W4304688766 cites W1968969468 @default.
- W4304688766 cites W1971013077 @default.
- W4304688766 cites W1971165751 @default.
- W4304688766 cites W1973221039 @default.
- W4304688766 cites W1973568247 @default.
- W4304688766 cites W1976078521 @default.
- W4304688766 cites W1980180109 @default.
- W4304688766 cites W1987908519 @default.
- W4304688766 cites W1993344012 @default.
- W4304688766 cites W2001258296 @default.
- W4304688766 cites W2004630197 @default.
- W4304688766 cites W2006288875 @default.
- W4304688766 cites W2008255210 @default.
- W4304688766 cites W2010873488 @default.
- W4304688766 cites W2012276721 @default.
- W4304688766 cites W2016661249 @default.
- W4304688766 cites W2017046792 @default.
- W4304688766 cites W2018288777 @default.
- W4304688766 cites W2030017878 @default.
- W4304688766 cites W2038268416 @default.
- W4304688766 cites W2039099895 @default.
- W4304688766 cites W2042365294 @default.
- W4304688766 cites W2052975116 @default.
- W4304688766 cites W2053108462 @default.
- W4304688766 cites W2054812499 @default.
- W4304688766 cites W2062214822 @default.
- W4304688766 cites W2064442490 @default.
- W4304688766 cites W2072789685 @default.
- W4304688766 cites W2073214780 @default.
- W4304688766 cites W2074548008 @default.
- W4304688766 cites W2075300416 @default.
- W4304688766 cites W2075537604 @default.
- W4304688766 cites W2081278227 @default.
- W4304688766 cites W2081938446 @default.
- W4304688766 cites W2083581022 @default.
- W4304688766 cites W2084833108 @default.
- W4304688766 cites W2088245621 @default.
- W4304688766 cites W2088580309 @default.
- W4304688766 cites W2089244618 @default.
- W4304688766 cites W2108371618 @default.
- W4304688766 cites W2108646201 @default.
- W4304688766 cites W2121717006 @default.
- W4304688766 cites W2134694706 @default.
- W4304688766 cites W2137220794 @default.
- W4304688766 cites W2140080780 @default.
- W4304688766 cites W2140817080 @default.
- W4304688766 cites W2142300779 @default.
- W4304688766 cites W2144940507 @default.
- W4304688766 cites W2145779272 @default.
- W4304688766 cites W2146512475 @default.
- W4304688766 cites W2150840254 @default.
- W4304688766 cites W2152061559 @default.
- W4304688766 cites W2160076878 @default.
- W4304688766 cites W2162218188 @default.
- W4304688766 cites W2164293876 @default.
- W4304688766 cites W2165516140 @default.
- W4304688766 cites W2170490448 @default.
- W4304688766 cites W2177689130 @default.
- W4304688766 cites W2182664595 @default.
- W4304688766 cites W2259572413 @default.
- W4304688766 cites W2260951263 @default.
- W4304688766 cites W2294957859 @default.
- W4304688766 cites W2295526061 @default.
- W4304688766 cites W2316375349 @default.
- W4304688766 cites W2414771725 @default.
- W4304688766 cites W2466204471 @default.
- W4304688766 cites W2515472395 @default.
- W4304688766 cites W2525290462 @default.
- W4304688766 cites W2529657394 @default.
- W4304688766 cites W2529873061 @default.
- W4304688766 cites W2558219863 @default.
- W4304688766 cites W2562305489 @default.
- W4304688766 cites W2569996114 @default.
- W4304688766 cites W2573221347 @default.
- W4304688766 cites W2574604975 @default.
- W4304688766 cites W2582545871 @default.
- W4304688766 cites W2587300163 @default.
- W4304688766 cites W2588778011 @default.
- W4304688766 cites W2588804631 @default.
- W4304688766 cites W2600686376 @default.
- W4304688766 cites W2608700009 @default.
- W4304688766 cites W2609243345 @default.