Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304693515> ?p ?o ?g. }
- W4304693515 abstract "Spatiotemporally dynamic microtubule acetylation underlies diverse physiological and pathological events. Despite its ubiquity, the molecular mechanisms that regulate the sole microtubule acetylating agent, α-tubulin-N-acetyltransferase-1 (α-TAT1), remain obscure. Here, we report that dynamic intracellular localization of α-TAT1 along with its catalytic activity determines efficiency of microtubule acetylation. Specifically, we newly identified a conserved signal motif in the intrinsically disordered C-terminus of α-TAT1, consisting of three competing regulatory elements—nuclear export, nuclear import, and cytosolic retention. Their balance is tuned via phosphorylation by CDK1, PKA, and CK2, and dephosphorylation by PP2A. While the unphosphorylated form binds to importins and resides both in cytosol and nucleus, the phosphorylated form binds to specific 14-3-3 adapters and accumulates in the cytosol for maximal substrate access. Unlike other molecules with a similar phospho-regulated signal motif, α-TAT1 uniquely uses the nucleus as a hideout. This allosteric spatial regulation of α-TAT1 function may help uncover a spatiotemporal code of microtubule acetylation in normal and aberrant cell behavior." @default.
- W4304693515 created "2022-10-12" @default.
- W4304693515 creator A5028916330 @default.
- W4304693515 creator A5033031282 @default.
- W4304693515 creator A5038005619 @default.
- W4304693515 creator A5041327556 @default.
- W4304693515 creator A5072918878 @default.
- W4304693515 creator A5073501871 @default.
- W4304693515 date "2022-10-12" @default.
- W4304693515 modified "2023-10-16" @default.
- W4304693515 title "Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation" @default.
- W4304693515 cites W1494730114 @default.
- W4304693515 cites W1900565974 @default.
- W4304693515 cites W1913244564 @default.
- W4304693515 cites W1965497411 @default.
- W4304693515 cites W1968031368 @default.
- W4304693515 cites W1971648238 @default.
- W4304693515 cites W1976572901 @default.
- W4304693515 cites W1978153762 @default.
- W4304693515 cites W1983287978 @default.
- W4304693515 cites W1984167248 @default.
- W4304693515 cites W1985389450 @default.
- W4304693515 cites W1990283596 @default.
- W4304693515 cites W1994199763 @default.
- W4304693515 cites W1996234606 @default.
- W4304693515 cites W2002705190 @default.
- W4304693515 cites W2006971960 @default.
- W4304693515 cites W2007040549 @default.
- W4304693515 cites W2009826707 @default.
- W4304693515 cites W2009996200 @default.
- W4304693515 cites W2010752097 @default.
- W4304693515 cites W2014885180 @default.
- W4304693515 cites W2015115860 @default.
- W4304693515 cites W2016984877 @default.
- W4304693515 cites W2017958579 @default.
- W4304693515 cites W2024935879 @default.
- W4304693515 cites W2025963872 @default.
- W4304693515 cites W2026231028 @default.
- W4304693515 cites W2029321925 @default.
- W4304693515 cites W2037954444 @default.
- W4304693515 cites W2042956459 @default.
- W4304693515 cites W2049503488 @default.
- W4304693515 cites W2057952525 @default.
- W4304693515 cites W2062233810 @default.
- W4304693515 cites W2062584366 @default.
- W4304693515 cites W2065782380 @default.
- W4304693515 cites W2067508252 @default.
- W4304693515 cites W2071075259 @default.
- W4304693515 cites W2072853614 @default.
- W4304693515 cites W2073031672 @default.
- W4304693515 cites W2078636815 @default.
- W4304693515 cites W2084733583 @default.
- W4304693515 cites W2089324848 @default.
- W4304693515 cites W2089393338 @default.
- W4304693515 cites W2092904031 @default.
- W4304693515 cites W2102818658 @default.
- W4304693515 cites W2104221028 @default.
- W4304693515 cites W2110844810 @default.
- W4304693515 cites W2112445405 @default.
- W4304693515 cites W2118052892 @default.
- W4304693515 cites W2119483030 @default.
- W4304693515 cites W2124343538 @default.
- W4304693515 cites W2133302149 @default.
- W4304693515 cites W2134547388 @default.
- W4304693515 cites W2144781426 @default.
- W4304693515 cites W2147008614 @default.
- W4304693515 cites W2150737519 @default.
- W4304693515 cites W2152482858 @default.
- W4304693515 cites W2153316664 @default.
- W4304693515 cites W2154626333 @default.
- W4304693515 cites W2155768517 @default.
- W4304693515 cites W2156961771 @default.
- W4304693515 cites W2158173168 @default.
- W4304693515 cites W2158617540 @default.
- W4304693515 cites W2161033372 @default.
- W4304693515 cites W2164943629 @default.
- W4304693515 cites W2168979150 @default.
- W4304693515 cites W2170105403 @default.
- W4304693515 cites W2511360805 @default.
- W4304693515 cites W2513478105 @default.
- W4304693515 cites W2549206510 @default.
- W4304693515 cites W2563769512 @default.
- W4304693515 cites W2591669685 @default.
- W4304693515 cites W2606253816 @default.
- W4304693515 cites W2607936681 @default.
- W4304693515 cites W2614969871 @default.
- W4304693515 cites W2761972346 @default.
- W4304693515 cites W2767701826 @default.
- W4304693515 cites W2775650492 @default.
- W4304693515 cites W2791455737 @default.
- W4304693515 cites W2804761187 @default.
- W4304693515 cites W2805111175 @default.
- W4304693515 cites W2806884808 @default.
- W4304693515 cites W2807384194 @default.
- W4304693515 cites W2807814263 @default.
- W4304693515 cites W2809616408 @default.
- W4304693515 cites W2885129214 @default.
- W4304693515 cites W2890048861 @default.
- W4304693515 cites W2892160808 @default.
- W4304693515 cites W2898789672 @default.