FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304693624> ?p ?o ?g. }

• W4304693624 endingPage "18591" @default.
• W4304693624 startingPage "18579" @default.
• W4304693624 abstract "Inflammation plays an important role in the development of rheumatoid arthritis (RA). NR4A1 is an anti-inflammatory orphan nuclear receptor involved in protection from inflammatory stimuli in RA. In this study we have explored the anti-inflammatory potential of the FDA-approved drug 9-aminoacridine (9AA) and the natural compound caffeic acid (CA) conjugated to nanomicelles for the treatment of RA. We have synthesized methoxy polyethylene glycol polycaprolactone block copolymer (mPEG-b-PCL) by ring opening polymerization of ε-caprolactone. Then, we conjugated the hydrophilic caffeic acid (CA) with mPEG-b-PCL micelles via Steglich esterification and incorporated the 9AA drug. These nanomicelles were formulated by the solvent evaporation method with a size distribution around 190 nm and showed maximum drug loading capacity along with sustained drug release behavior. Furthermore, we tested the therapeutic potential of the formulated 9AA-encapsulated CA-conjugated nanomicelles (9AA-NMs) against an experimental RA model. We observed promising results which showed alleviation of arthritic symptoms by reducing inflammation, joint damage, bone erosion, and swelling. Further, collagen destruction was significantly reduced in articular cartilage, as shown by safranin-O and toluidine blue staining. The protective mechanism might be due to the simultaneous inhibition of NF-κB by 9AA and CA, whereas the activation of NR4A1 by 9AA leads to the suppression of HIF-1α. This combined therapeutic effect of 9AA and CA has enhanced the therapeutic efficacy of 9AA-NM and markedly reduced the severity of inflammatory arthritis. Unlike existing drugs for pain management and with limited efficacy, 9AA-NM exerted a disease-relevant activation/blockade that alleviated inflammation and exhibited marked therapeutic efficacy against RA." @default.
• W4304693624 created "2022-10-12" @default.
• W4304693624 creator A5000985232 @default.
• W4304693624 creator A5029751940 @default.
• W4304693624 creator A5036589842 @default.
• W4304693624 creator A5050167205 @default.
• W4304693624 creator A5063583565 @default.
• W4304693624 creator A5089758995 @default.
• W4304693624 date "2022-10-12" @default.
• W4304693624 modified "2023-10-16" @default.
• W4304693624 title "Caffeic Acid Modified Nanomicelles Inhibit Articular Cartilage Deterioration and Reduce Disease Severity in Experimental Inflammatory Arthritis" @default.
• W4304693624 cites W1521338784 @default.
• W4304693624 cites W1863597969 @default.
• W4304693624 cites W1894605302 @default.
• W4304693624 cites W2011038175 @default.
• W4304693624 cites W2025001196 @default.
• W4304693624 cites W2054679021 @default.
• W4304693624 cites W2062874552 @default.
• W4304693624 cites W2072596279 @default.
• W4304693624 cites W2082368727 @default.
• W4304693624 cites W2082964214 @default.
• W4304693624 cites W2101787021 @default.
• W4304693624 cites W2103768330 @default.
• W4304693624 cites W2110578003 @default.
• W4304693624 cites W2115524611 @default.
• W4304693624 cites W2155402987 @default.
• W4304693624 cites W2322047794 @default.
• W4304693624 cites W2611175621 @default.
• W4304693624 cites W2735527928 @default.
• W4304693624 cites W2793851311 @default.
• W4304693624 cites W2883823725 @default.
• W4304693624 cites W2888552632 @default.
• W4304693624 cites W2904505935 @default.
• W4304693624 cites W2941727130 @default.
• W4304693624 cites W2947855791 @default.
• W4304693624 cites W2954541576 @default.
• W4304693624 cites W3002916064 @default.
• W4304693624 cites W3005664089 @default.
• W4304693624 cites W3012902805 @default.
• W4304693624 cites W3026443040 @default.
• W4304693624 cites W3036517252 @default.
• W4304693624 cites W3048150263 @default.
• W4304693624 cites W3118505746 @default.
• W4304693624 cites W3134531697 @default.
• W4304693624 cites W3195031434 @default.
• W4304693624 cites W4211111012 @default.
• W4304693624 cites W4214564120 @default.
• W4304693624 cites W4223500675 @default.
• W4304693624 cites W4225501694 @default.
• W4304693624 doi "https://doi.org/10.1021/acsnano.2c07027" @default.
• W4304693624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36222569" @default.
• W4304693624 hasPublicationYear "2022" @default.
• W4304693624 type Work @default.
• W4304693624 citedByCount "7" @default.
• W4304693624 countsByYear W43046936242022 @default.
• W4304693624 countsByYear W43046936242023 @default.
• W4304693624 crossrefType "journal-article" @default.
• W4304693624 hasAuthorship W4304693624A5000985232 @default.
• W4304693624 hasAuthorship W4304693624A5029751940 @default.
• W4304693624 hasAuthorship W4304693624A5036589842 @default.
• W4304693624 hasAuthorship W4304693624A5050167205 @default.
• W4304693624 hasAuthorship W4304693624A5063583565 @default.
• W4304693624 hasAuthorship W4304693624A5089758995 @default.
• W4304693624 hasConcept C185592680 @default.
• W4304693624 hasConcept C203014093 @default.
• W4304693624 hasConcept C2776914184 @default.
• W4304693624 hasConcept C2776964284 @default.
• W4304693624 hasConcept C2777077863 @default.
• W4304693624 hasConcept C2777575956 @default.
• W4304693624 hasConcept C2779703632 @default.
• W4304693624 hasConcept C55493867 @default.
• W4304693624 hasConcept C71924100 @default.
• W4304693624 hasConcept C98274493 @default.
• W4304693624 hasConceptScore W4304693624C185592680 @default.
• W4304693624 hasConceptScore W4304693624C203014093 @default.
• W4304693624 hasConceptScore W4304693624C2776914184 @default.
• W4304693624 hasConceptScore W4304693624C2776964284 @default.
• W4304693624 hasConceptScore W4304693624C2777077863 @default.
• W4304693624 hasConceptScore W4304693624C2777575956 @default.
• W4304693624 hasConceptScore W4304693624C2779703632 @default.
• W4304693624 hasConceptScore W4304693624C55493867 @default.
• W4304693624 hasConceptScore W4304693624C71924100 @default.
• W4304693624 hasConceptScore W4304693624C98274493 @default.
• W4304693624 hasFunder F4320334771 @default.
• W4304693624 hasIssue "11" @default.
• W4304693624 hasLocation W43046936241 @default.
• W4304693624 hasLocation W43046936242 @default.
• W4304693624 hasOpenAccess W4304693624 @default.
• W4304693624 hasPrimaryLocation W43046936241 @default.
• W4304693624 hasRelatedWork W2035895330 @default.
• W4304693624 hasRelatedWork W2150503314 @default.
• W4304693624 hasRelatedWork W2350467063 @default.
• W4304693624 hasRelatedWork W2354851361 @default.
• W4304693624 hasRelatedWork W2384738060 @default.
• W4304693624 hasRelatedWork W2393345915 @default.
• W4304693624 hasRelatedWork W2416097977 @default.
• W4304693624 hasRelatedWork W2993678931 @default.
• W4304693624 hasRelatedWork W3045583548 @default.

• next