FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304694180> ?p ?o ?g. }

• W4304694180 abstract "Abstract Background Pyroptosis-related long noncoding RNAs (lncRNAs) (PRLs) are closely related to gastric cancer (GC). However, However, the mechanism of its role in GC has not been elaborated. This study deeply analyzed the potential role of PRL in GC. Methods A PRLs coexpression network was constructed via GC data from the TCGA dataset. Cox analysis was used to determine the prognosis related PRLs. QRT–PCR was used for quantitative verification. LASSO analysis and multivariate Cox analysis were used to construct the prognosis model of PRLs and calculate the risk score of each sample. The clinical characteristics, prognosis and tumor microenvironment (TME) of different risk groups were analyzed. Finally, we constructed a ceRNA network of lncRNA miRNA/mRNA and five histone modification modes (H3K27ac, H3K4me1, H3K17me3, H3K4me3, and H3K9me3). Results We obtained seven PRLs and constructed a prognostic model. In addition, we also drew a highly accurate nomogram to predict the prognosis of GC. The expression of lncRNAs AP000695.1 and AC087301.1 was significantly different between GC tissues and normal tissues. The immune function and TME also changed in different risk groups. We found the sub-networks of miRNAs and target genes related to AP000695.1 and AC243964.3. And we also found that the AC007277.1 enhancer region H3K27ac, H3K4me1, H3K4me3 levels increased. Conclusion This study revealed the clinical features, prognosis and tumor microenvironment of PRL in gastric cancer, and further explored its potential role in GC. This study revealed the clinical characteristics, prognosis and tumor microenvironment of PRLs in GC. The potential role in GC was discussed, which provided a new theoretical basis and ideas for immunotherapy of GC." @default.
• W4304694180 created "2022-10-12" @default.
• W4304694180 creator A5007312763 @default.
• W4304694180 creator A5042748112 @default.
• W4304694180 creator A5049788753 @default.
• W4304694180 creator A5055414732 @default.
• W4304694180 creator A5088541895 @default.
• W4304694180 date "2022-10-12" @default.
• W4304694180 modified "2023-09-27" @default.
• W4304694180 title "Identification of a novel pyroptosis related long noncoding RNA subtypes, development of a prognostic model and characteristics of the tumor microenvironment in gastric cancer" @default.
• W4304694180 cites W1967925876 @default.
• W4304694180 cites W1975303054 @default.
• W4304694180 cites W2021120490 @default.
• W4304694180 cites W2036710606 @default.
• W4304694180 cites W2039345836 @default.
• W4304694180 cites W2046387002 @default.
• W4304694180 cites W2049553585 @default.
• W4304694180 cites W2060414933 @default.
• W4304694180 cites W2091161969 @default.
• W4304694180 cites W2104885590 @default.
• W4304694180 cites W2129769331 @default.
• W4304694180 cites W2172312226 @default.
• W4304694180 cites W2299181842 @default.
• W4304694180 cites W2311746741 @default.
• W4304694180 cites W2528690964 @default.
• W4304694180 cites W2556998487 @default.
• W4304694180 cites W2560541542 @default.
• W4304694180 cites W2622499649 @default.
• W4304694180 cites W2765694924 @default.
• W4304694180 cites W2766209631 @default.
• W4304694180 cites W2790388852 @default.
• W4304694180 cites W2793057829 @default.
• W4304694180 cites W2797855256 @default.
• W4304694180 cites W2802776623 @default.
• W4304694180 cites W2804972379 @default.
• W4304694180 cites W2883796806 @default.
• W4304694180 cites W2885715971 @default.
• W4304694180 cites W2888546921 @default.
• W4304694180 cites W2889646458 @default.
• W4304694180 cites W2902192147 @default.
• W4304694180 cites W2975736787 @default.
• W4304694180 cites W2977026913 @default.
• W4304694180 cites W2977165675 @default.
• W4304694180 cites W2989479791 @default.
• W4304694180 cites W3003957314 @default.
• W4304694180 cites W3005209704 @default.
• W4304694180 cites W3082555410 @default.
• W4304694180 cites W3091800556 @default.
• W4304694180 cites W3094916111 @default.
• W4304694180 cites W3128646645 @default.
• W4304694180 cites W3141710402 @default.
• W4304694180 cites W3144571741 @default.
• W4304694180 cites W3153541595 @default.
• W4304694180 cites W3197015296 @default.
• W4304694180 cites W3197859532 @default.
• W4304694180 cites W3197896101 @default.
• W4304694180 cites W3202814778 @default.
• W4304694180 cites W3214699897 @default.
• W4304694180 cites W3216960060 @default.
• W4304694180 cites W4213262486 @default.
• W4304694180 cites W92471217 @default.
• W4304694180 doi "https://doi.org/10.21203/rs.3.rs-2080757/v1" @default.
• W4304694180 hasPublicationYear "2022" @default.
• W4304694180 type Work @default.
• W4304694180 citedByCount "0" @default.
• W4304694180 crossrefType "posted-content" @default.
• W4304694180 hasAuthorship W4304694180A5007312763 @default.
• W4304694180 hasAuthorship W4304694180A5042748112 @default.
• W4304694180 hasAuthorship W4304694180A5049788753 @default.
• W4304694180 hasAuthorship W4304694180A5055414732 @default.
• W4304694180 hasAuthorship W4304694180A5088541895 @default.
• W4304694180 hasBestOaLocation W43046941801 @default.
• W4304694180 hasConcept C101762097 @default.
• W4304694180 hasConcept C104317684 @default.
• W4304694180 hasConcept C121608353 @default.
• W4304694180 hasConcept C143998085 @default.
• W4304694180 hasConcept C145059251 @default.
• W4304694180 hasConcept C150194340 @default.
• W4304694180 hasConcept C2776107976 @default.
• W4304694180 hasConcept C2780914512 @default.
• W4304694180 hasConcept C34626388 @default.
• W4304694180 hasConcept C502942594 @default.
• W4304694180 hasConcept C54355233 @default.
• W4304694180 hasConcept C60365752 @default.
• W4304694180 hasConcept C62203573 @default.
• W4304694180 hasConcept C67705224 @default.
• W4304694180 hasConcept C70721500 @default.
• W4304694180 hasConcept C71924100 @default.
• W4304694180 hasConcept C86803240 @default.
• W4304694180 hasConceptScore W4304694180C101762097 @default.
• W4304694180 hasConceptScore W4304694180C104317684 @default.
• W4304694180 hasConceptScore W4304694180C121608353 @default.
• W4304694180 hasConceptScore W4304694180C143998085 @default.
• W4304694180 hasConceptScore W4304694180C145059251 @default.
• W4304694180 hasConceptScore W4304694180C150194340 @default.
• W4304694180 hasConceptScore W4304694180C2776107976 @default.
• W4304694180 hasConceptScore W4304694180C2780914512 @default.
• W4304694180 hasConceptScore W4304694180C34626388 @default.
• W4304694180 hasConceptScore W4304694180C502942594 @default.
• W4304694180 hasConceptScore W4304694180C54355233 @default.

• next