FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304694516> ?p ?o ?g. }

• W4304694516 abstract "Angiotensin-converting enzyme 2 (ACE2) expressions and its modulation are of great interest as being a key receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and the protective arm of the rennin-angiotensin axis, maintaining cardiovascular homeostasis. However, ACE2 expressions and their modulation in the healthy and disease background are yet to be explored.We performed a meta-analysis, extracting the data for ACE2 expression in human subjects with various diseases, including SARS-CoV2 infection without or with co-morbidity. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Out of 203 studies, 39 met the inclusion criteria with SARS-CoV2 patients without co-morbidity, SARS-CoV2 patients with co-morbidity, cardiovascular (CVD) patients, diabetes patients, kidney disorders patients, pulmonary disease patients, and other viral infections patients.Angiotensin-converting enzyme 2 expression was significantly increased in all diseases. There was an elevated level of ACE2, especially membrane-bound ACE2, in COVID-19 patients compared to healthy controls. A statistically significant increase in ACE2 expression was observed in CVD patients and patients with other viral diseases compared to healthy subjects. Moreover, subgroup analysis of ACE2 expression as soluble and membrane-bound ACE2 revealed a remarkable increase in membrane-bound ACE2 in CVD patients, patients with viral infection compared to soluble ACE2 and pooled standard mean difference (SMD) with the random-effects model was 0.37 and 2.23 respectively.It was observed that utilizing the ACE2 by SARS-CoV2 for its entry and its consequence leads to several complications. So there is a need to investigate the underlying mechanism along with novel therapeutic strategies." @default.
• W4304694516 created "2022-10-12" @default.
• W4304694516 creator A5003551286 @default.
• W4304694516 creator A5052878746 @default.
• W4304694516 creator A5062729631 @default.
• W4304694516 creator A5076703561 @default.
• W4304694516 creator A5085072375 @default.
• W4304694516 date "2022-10-25" @default.
• W4304694516 modified "2023-10-01" @default.
• W4304694516 title "Angiotensin converting enzyme 2 level and its significance in COVID‐19 and other diseases patients" @default.
• W4304694516 cites W1581300995 @default.
• W4304694516 cites W1917963654 @default.
• W4304694516 cites W1975428045 @default.
• W4304694516 cites W1983428551 @default.
• W4304694516 cites W2006572986 @default.
• W4304694516 cites W2007591654 @default.
• W4304694516 cites W2010261215 @default.
• W4304694516 cites W2014491720 @default.
• W4304694516 cites W2029971767 @default.
• W4304694516 cites W2062817591 @default.
• W4304694516 cites W2079016258 @default.
• W4304694516 cites W2125208804 @default.
• W4304694516 cites W2130687910 @default.
• W4304694516 cites W2134833483 @default.
• W4304694516 cites W2171032622 @default.
• W4304694516 cites W2255789882 @default.
• W4304694516 cites W2318532368 @default.
• W4304694516 cites W2400693771 @default.
• W4304694516 cites W2531500310 @default.
• W4304694516 cites W2567362164 @default.
• W4304694516 cites W2590408385 @default.
• W4304694516 cites W2769223956 @default.
• W4304694516 cites W2807942438 @default.
• W4304694516 cites W2978795816 @default.
• W4304694516 cites W3004071935 @default.
• W4304694516 cites W3008295344 @default.
• W4304694516 cites W3009912996 @default.
• W4304694516 cites W3014027512 @default.
• W4304694516 cites W3014067025 @default.
• W4304694516 cites W3016148207 @default.
• W4304694516 cites W3017331996 @default.
• W4304694516 cites W3018108347 @default.
• W4304694516 cites W3022435472 @default.
• W4304694516 cites W3024068183 @default.
• W4304694516 cites W3024090047 @default.
• W4304694516 cites W3025141218 @default.
• W4304694516 cites W3026328714 @default.
• W4304694516 cites W3034054656 @default.
• W4304694516 cites W3040907131 @default.
• W4304694516 cites W3041348343 @default.
• W4304694516 cites W3042292025 @default.
• W4304694516 cites W3043002108 @default.
• W4304694516 cites W3044069820 @default.
• W4304694516 cites W3046889193 @default.
• W4304694516 cites W3047325955 @default.
• W4304694516 cites W3054686440 @default.
• W4304694516 cites W3082217150 @default.
• W4304694516 cites W3091863087 @default.
• W4304694516 cites W3107969164 @default.
• W4304694516 cites W3113189927 @default.
• W4304694516 cites W3119344443 @default.
• W4304694516 cites W3123786390 @default.
• W4304694516 cites W3128439668 @default.
• W4304694516 cites W3135511673 @default.
• W4304694516 cites W3157319468 @default.
• W4304694516 cites W3157415407 @default.
• W4304694516 cites W3161620029 @default.
• W4304694516 cites W3164646585 @default.
• W4304694516 cites W3175672910 @default.
• W4304694516 cites W3176412535 @default.
• W4304694516 cites W3180742214 @default.
• W4304694516 cites W4205132816 @default.
• W4304694516 cites W4220845299 @default.
• W4304694516 cites W4232923927 @default.
• W4304694516 cites W4281568206 @default.
• W4304694516 cites W4304694516 @default.
• W4304694516 doi "https://doi.org/10.1111/eci.13891" @default.
• W4304694516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36222740" @default.
• W4304694516 hasPublicationYear "2022" @default.
• W4304694516 type Work @default.
• W4304694516 citedByCount "2" @default.
• W4304694516 countsByYear W43046945162022 @default.
• W4304694516 countsByYear W43046945162023 @default.
• W4304694516 crossrefType "journal-article" @default.
• W4304694516 hasAuthorship W4304694516A5003551286 @default.
• W4304694516 hasAuthorship W4304694516A5052878746 @default.
• W4304694516 hasAuthorship W4304694516A5062729631 @default.
• W4304694516 hasAuthorship W4304694516A5076703561 @default.
• W4304694516 hasAuthorship W4304694516A5085072375 @default.
• W4304694516 hasBestOaLocation W43046945162 @default.
• W4304694516 hasConcept C126322002 @default.
• W4304694516 hasConcept C134018914 @default.
• W4304694516 hasConcept C198710026 @default.
• W4304694516 hasConcept C203014093 @default.
• W4304694516 hasConcept C27016395 @default.
• W4304694516 hasConcept C2775946041 @default.
• W4304694516 hasConcept C2779134260 @default.
• W4304694516 hasConcept C3008058167 @default.
• W4304694516 hasConcept C524204448 @default.
• W4304694516 hasConcept C555293320 @default.

• next