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- W4304698312 abstract "Older adults represent a vulnerable population with elevated risk for numerous morbidities. To explore the association of the microbiome with aging and age-related susceptibilities, including frailty and infectious disease risk, we conducted a longitudinal study of the skin, oral, and gut microbiota in 47 community- or skilled nursing facility-dwelling older adults versus younger adults. We found that microbiome changes were not associated with chronological age so much as frailty; we identified prominent changes in microbiome features associated with susceptibility to pathogen colonization and disease risk, including diversity, stability, heterogeneity and biogeographic determinism, which were moreover associated with a loss of Cutibacterium acnes in the skin microbiome. Strikingly, the skin microbiota were also the primary reservoir for antimicrobial resistance, clinically important pathobionts and nosocomial strains, suggesting a potential role particularly for the skin microbiome in disease risk and dissemination of multidrug resistant pathogens. A metagenomic study of gut, oral and skin microbiota describes a pattern of microbial dysbiosis in more frail institutionalized older adults and identifies the skin as the major reservoir of pathogenicity." @default.
- W4304698312 created "2022-10-12" @default.
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- W4304698312 date "2022-10-12" @default.
- W4304698312 modified "2023-10-15" @default.
- W4304698312 title "Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults" @default.
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