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- W4304754999 abstract "Introduction: Pyoderma gangrenosum (PG) refers to an autoinflammatory cutaneous disorder characterized by bizarre painful ulcerations. Clinical data of pediatric PG are rare in China. We herein present the first report of adalimumab in the treatment of pediatric PG in China. Case presentation: An 8-year-old boy presented with multiple painful ulcerations on both lower legs. He was diagnosed with PG according to his clinical manifestations and results of a histological examination. His condition showed resistance to corticosteroids, immunosuppressants, and even intravenous immunoglobulin. We then treated him with adalimumab, which induced remission of the disease. Discussion: PG poses both diagnostic and therapeutic challenges. Increased levels of inflammatory mediators, including interleukins 1β, 8, and 17 and tumor necrosis factor-α, induce development of the disease. Despite the availability of traditional treatments, new therapeutic regimens should be taken into consideration. Conclusion: No previous data regarding adalimumab for the treatment of pediatric PG have been reported in China. Our case demonstrates that adalimumab has a beneficial effect on pediatric patients with recalcitrant PG. However, further evaluation and long-term follow-up of this treatment are required. Because infliximab has been studied in a randomized, double blind, placebo-controlled trial, we anticipate forthcoming multicenter randomized trials and research of adalimumab." @default.
- W4304754999 created "2022-10-13" @default.
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- W4304754999 date "2022-10-12" @default.
- W4304754999 modified "2023-09-25" @default.
- W4304754999 title "Recalcitrant pediatric pyoderma gangrenosum controlled with adalimumab" @default.
- W4304754999 doi "https://doi.org/10.1097/jd9.0000000000000258" @default.
- W4304754999 hasPublicationYear "2022" @default.
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