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• W4304757978 abstract "Abstract Lipid peroxides accumulation induced ferroptosis is an effective cell death pathway for cancer therapy. However, the hypoxic condition of tumor microenvironment significantly suppresses the efficacy of ferroptosis. Here, we design a novel nanoplatform to overcome hypoxia‐induced ferroptosis resistance. Specifically, we synthesize a novel kind of perfluorocarbon (PFOB)@manganese oxide (MnOx) core‐shell nanoparticles (PM‐CS NPs). Owing to the good carrier of O 2 as fuel, PM‐CS NPs can induce higher level of ROS generation, lipid peroxidation and GSH depletion, as well as lower activity of GPX4, compared with MnOx NPs alone. Moreover, the supplement of O 2 can relieve tumor hypoxia to break down the storage of intracellular lipid droplets and increase expression of ACSL4 (a symbol for ferroptosis sensitivity). Furthermore, upon stimulus of GSH or acidity, PM‐CS NPs exhibit the “turn on” 19 F‐MRI signal and activatable T 1 /T 2 ‐MRI contrast for correlating with the release of Mn. Finally, PM‐CS NPs exert high cancer inhibition rate for ferroptosis based therapy via synergetic combination of O 2 ‐mediated enhancement of key pathways of ferroptosis." @default.
• W4304757978 created "2022-10-13" @default.
• W4304757978 creator A5009435619 @default.
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• W4304757978 creator A5085772896 @default.
• W4304757978 date "2022-10-27" @default.
• W4304757978 modified "2023-10-16" @default.
• W4304757978 title "Overcoming Hypoxia‐Induced Ferroptosis Resistance via a ¹⁹F/¹H‐MRI Traceable Core‐Shell Nanostructure" @default.
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• W4304757978 doi "https://doi.org/10.1002/anie.202206074" @default.
• W4304757978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36222012" @default.
• W4304757978 hasPublicationYear "2022" @default.
• W4304757978 type Work @default.
• W4304757978 citedByCount "20" @default.

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