FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304758052> ?p ?o ?g. }

• W4304758052 endingPage "130" @default.
• W4304758052 startingPage "124" @default.
• W4304758052 abstract "Ovarian clear cell carcinoma (OCCC), a chemoresistant ovarian cancer, shows a modest response to anti-programmed death-1/programmed death ligand-1 (PD-1/PD-L1) therapies. The effects of anti-PD-1/PD-L1 therapies rely on cytotoxic T-cell response, which is triggered by antigen presentation mediated by major histocompatibility complex (MHC) class I. The loss of MHC class I with simultaneous PD-L1 expression has been noted in several cancer types; however, these findings and their prognostic value have rarely been evaluated in OCCC. We collected data from 76 patients with OCCC for clinicopathologic analysis. Loss of MHC class I expression was seen in 44.7% of the cases including 39.3% to 47.4% of the PD-L1 + cases and was associated with fewer CD8 + tumor-infiltrating lymphocytes (TILs). PD-L1 positivity was associated with a higher number of CD8 + TILs. Cox proportional hazard models showed that high (≥50/mm 2 ) CD8 + TILs was associated with shorter disease-specific survival (hazard ratio [HR]=3.447, 95% confidence interval [CI]: 1.222-9.720, P =0.019) and overall survival (HR=3.053, 95% CI: 1.105-8.43, P =0.031). PD-L1 positivity using Combined Positive Score was associated with shorter progression-free survival (HR=3.246, 95% CI: 1.435-7.339, P =0.005), disease-specific survival (HR=4.124, 95% CI: 1.403-12.116, P =0.010), and overall survival (HR=4.489, 95% CI: 1.553-12.972, P =0.006). Loss of MHC class I may contribute to immune evasion and resistance to anti-PD-1/PD-L1 therapies in OCCC, and CD8 + TILs and PD-L1 positivity using Combined Positive Score may have a negative prognostic value." @default.
• W4304758052 created "2022-10-13" @default.
• W4304758052 creator A5018168834 @default.
• W4304758052 creator A5020069509 @default.
• W4304758052 creator A5033097075 @default.
• W4304758052 creator A5033839875 @default.
• W4304758052 creator A5038736655 @default.
• W4304758052 creator A5056329305 @default.
• W4304758052 creator A5057719085 @default.
• W4304758052 creator A5060886876 @default.
• W4304758052 date "2022-10-11" @default.
• W4304758052 modified "2023-09-23" @default.
• W4304758052 title "Loss of Major Histocompatibility Complex Class I, CD8+ Tumor-infiltrating Lymphocytes, and PD-L1 Expression in Ovarian Clear Cell Carcinoma" @default.
• W4304758052 cites W1949964307 @default.
• W4304758052 cites W1972882573 @default.
• W4304758052 cites W1984029678 @default.
• W4304758052 cites W2093773243 @default.
• W4304758052 cites W2099751212 @default.
• W4304758052 cites W2101653483 @default.
• W4304758052 cites W2107453087 @default.
• W4304758052 cites W2113149311 @default.
• W4304758052 cites W2115521843 @default.
• W4304758052 cites W2136313650 @default.
• W4304758052 cites W2142300779 @default.
• W4304758052 cites W2147210428 @default.
• W4304758052 cites W2151163706 @default.
• W4304758052 cites W2160834915 @default.
• W4304758052 cites W2169991956 @default.
• W4304758052 cites W2186690436 @default.
• W4304758052 cites W2285621780 @default.
• W4304758052 cites W2298468092 @default.
• W4304758052 cites W2300582328 @default.
• W4304758052 cites W2568525023 @default.
• W4304758052 cites W2591765176 @default.
• W4304758052 cites W2615736857 @default.
• W4304758052 cites W2740658377 @default.
• W4304758052 cites W2765953690 @default.
• W4304758052 cites W2776402318 @default.
• W4304758052 cites W2782007611 @default.
• W4304758052 cites W2790504144 @default.
• W4304758052 cites W2890261294 @default.
• W4304758052 cites W2924756687 @default.
• W4304758052 cites W2945183690 @default.
• W4304758052 cites W3021264705 @default.
• W4304758052 cites W3028523516 @default.
• W4304758052 cites W3031241733 @default.
• W4304758052 cites W3083611723 @default.
• W4304758052 cites W3091308448 @default.
• W4304758052 cites W3124715390 @default.
• W4304758052 cites W3134655285 @default.
• W4304758052 cites W3164890381 @default.
• W4304758052 cites W4226480857 @default.
• W4304758052 doi "https://doi.org/10.1097/pas.0000000000001975" @default.
• W4304758052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36221308" @default.
• W4304758052 hasPublicationYear "2022" @default.
• W4304758052 type Work @default.
• W4304758052 citedByCount "3" @default.
• W4304758052 countsByYear W43047580522023 @default.
• W4304758052 crossrefType "journal-article" @default.
• W4304758052 hasAuthorship W4304758052A5018168834 @default.
• W4304758052 hasAuthorship W4304758052A5020069509 @default.
• W4304758052 hasAuthorship W4304758052A5033097075 @default.
• W4304758052 hasAuthorship W4304758052A5033839875 @default.
• W4304758052 hasAuthorship W4304758052A5038736655 @default.
• W4304758052 hasAuthorship W4304758052A5056329305 @default.
• W4304758052 hasAuthorship W4304758052A5057719085 @default.
• W4304758052 hasAuthorship W4304758052A5060886876 @default.
• W4304758052 hasConcept C121608353 @default.
• W4304758052 hasConcept C126322002 @default.
• W4304758052 hasConcept C143998085 @default.
• W4304758052 hasConcept C154317977 @default.
• W4304758052 hasConcept C167672396 @default.
• W4304758052 hasConcept C170627219 @default.
• W4304758052 hasConcept C202751555 @default.
• W4304758052 hasConcept C203014093 @default.
• W4304758052 hasConcept C207103383 @default.
• W4304758052 hasConcept C207936829 @default.
• W4304758052 hasConcept C2777701055 @default.
• W4304758052 hasConcept C2778326572 @default.
• W4304758052 hasConcept C2780427987 @default.
• W4304758052 hasConcept C2781053074 @default.
• W4304758052 hasConcept C2781199814 @default.
• W4304758052 hasConcept C44249647 @default.
• W4304758052 hasConcept C55493867 @default.
• W4304758052 hasConcept C71924100 @default.
• W4304758052 hasConcept C86803240 @default.
• W4304758052 hasConcept C8891405 @default.
• W4304758052 hasConceptScore W4304758052C121608353 @default.
• W4304758052 hasConceptScore W4304758052C126322002 @default.
• W4304758052 hasConceptScore W4304758052C143998085 @default.
• W4304758052 hasConceptScore W4304758052C154317977 @default.
• W4304758052 hasConceptScore W4304758052C167672396 @default.
• W4304758052 hasConceptScore W4304758052C170627219 @default.
• W4304758052 hasConceptScore W4304758052C202751555 @default.
• W4304758052 hasConceptScore W4304758052C203014093 @default.
• W4304758052 hasConceptScore W4304758052C207103383 @default.
• W4304758052 hasConceptScore W4304758052C207936829 @default.
• W4304758052 hasConceptScore W4304758052C2777701055 @default.

• next