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- W4304758064 abstract "According to their lifestyle, plant pathogens are divided into biotrophic and necrotrophic organisms. Biotrophic pathogens exclusively nourish living host cells, whereas necrotrophic pathogens rapidly kill host cells and nourish cell walls and cell contents. To this end, the necrotrophic fungus Botrytis cinerea secretes large amounts of phytotoxic proteins and cell wall-degrading enzymes. However, the precise role of these proteins during infection is unknown. Here, we report on the identification and characterization of the previously unknown toxic protein hypersensitive response-inducing protein 1 (Hip1), which induces plant cell death. We found the adoption of a structurally conserved folded Alternaria alternata Alt a 1 protein structure to be a prerequisite for Hip1 to exert its necrosis-inducing activity in a host-specific manner. Localization and the induction of typical plant defense responses by Hip1 indicate recognition as a pathogen-associated molecular pattern at the plant plasma membrane. In contrast to other secreted toxic Botrytis proteins, the activity of Hip1 does not depend on the presence of the receptor-associated kinases BRI1-associated kinase 1 and suppressor of BIR1-1. Our results demonstrate that recognition of Hip1, even in the absence of obvious enzymatic or pore-forming activity, induces strong plant defense reactions eventually leading to plant cell death. Botrytis hip1 overexpression strains generated by CRISPR/Cas9 displayed enhanced infection, indicating the virulence-promoting potential of Hip1. Taken together, Hip1 induces a noncanonical defense response which might be a common feature of structurally conserved fungal proteins from the Alt a 1 family." @default.
- W4304758064 created "2022-10-13" @default.
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- W4304758064 date "2022-10-12" @default.
- W4304758064 modified "2023-10-14" @default.
- W4304758064 title "<i>Botrytis</i> hypersensitive response inducing protein 1 triggers noncanonical PTI to induce plant cell death" @default.
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- W4304758064 cites W1803102843 @default.
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- W4304758064 cites W1846389272 @default.
- W4304758064 cites W1848811406 @default.
- W4304758064 cites W1966640289 @default.
- W4304758064 cites W1966924595 @default.
- W4304758064 cites W1967276739 @default.
- W4304758064 cites W1970312062 @default.
- W4304758064 cites W1971323492 @default.
- W4304758064 cites W1975702905 @default.
- W4304758064 cites W1981427309 @default.
- W4304758064 cites W1984413641 @default.
- W4304758064 cites W2007427311 @default.
- W4304758064 cites W2010611859 @default.
- W4304758064 cites W2019873749 @default.
- W4304758064 cites W2029607585 @default.
- W4304758064 cites W2033707520 @default.
- W4304758064 cites W2036028864 @default.
- W4304758064 cites W2036783153 @default.
- W4304758064 cites W2041895974 @default.
- W4304758064 cites W2042322079 @default.
- W4304758064 cites W2054317956 @default.
- W4304758064 cites W2060581451 @default.
- W4304758064 cites W2061117777 @default.
- W4304758064 cites W2062893362 @default.
- W4304758064 cites W2074676413 @default.
- W4304758064 cites W2076198552 @default.
- W4304758064 cites W2077794197 @default.
- W4304758064 cites W2097748965 @default.
- W4304758064 cites W2106395760 @default.
- W4304758064 cites W2107277218 @default.
- W4304758064 cites W2108244474 @default.
- W4304758064 cites W2113117497 @default.
- W4304758064 cites W2114756078 @default.
- W4304758064 cites W2115545365 @default.
- W4304758064 cites W2118751052 @default.
- W4304758064 cites W2132059918 @default.
- W4304758064 cites W2139456772 @default.
- W4304758064 cites W2145688645 @default.
- W4304758064 cites W2162515800 @default.
- W4304758064 cites W2162779104 @default.
- W4304758064 cites W2171468481 @default.
- W4304758064 cites W2192080449 @default.
- W4304758064 cites W2325612663 @default.
- W4304758064 cites W2328421912 @default.
- W4304758064 cites W2427335733 @default.
- W4304758064 cites W2505457969 @default.
- W4304758064 cites W2529301660 @default.
- W4304758064 cites W2588571662 @default.
- W4304758064 cites W2626335789 @default.
- W4304758064 cites W2735494497 @default.
- W4304758064 cites W2743184154 @default.
- W4304758064 cites W2774012114 @default.
- W4304758064 cites W2799501975 @default.
- W4304758064 cites W2804014902 @default.
- W4304758064 cites W2894630387 @default.
- W4304758064 cites W2894928482 @default.
- W4304758064 cites W2904735955 @default.
- W4304758064 cites W2966845850 @default.
- W4304758064 cites W2980380301 @default.
- W4304758064 cites W3021684986 @default.
- W4304758064 cites W3041872784 @default.
- W4304758064 cites W3071572338 @default.
- W4304758064 cites W3091863986 @default.
- W4304758064 cites W3118631240 @default.
- W4304758064 cites W3177828909 @default.
- W4304758064 cites W3184544131 @default.
- W4304758064 cites W3211795435 @default.
- W4304758064 cites W4214858427 @default.
- W4304758064 cites W4220899085 @default.
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- W4304758064 doi "https://doi.org/10.1093/plphys/kiac476" @default.
- W4304758064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36222581" @default.
- W4304758064 hasPublicationYear "2022" @default.
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